I-T-Cell Lymphoma (CTCL) enqamukile i- lymphoma yesikhumba. I-CTCL ivela ku- T-cells , uhlobo lwe-lymphocyte noma i-white cell cell. I-CTCL ayiyona isifo esisodwa, kodwa iqembu lama-lymphomas ahlukahlukene aphazamisa isikhumba ngokuyinhloko kuhlanganisa:
- Mycosis fungoides,
- Isifo se-Sezary,
- I-reticulum cell sarcoma yesikhumba, futhi
- Ezinye ezinye ze-lymphomas ezingavamile.
I-lymphoma ngokuvamile ihilela ama- lymph nodes .
Noma kunjalo, amangqamuzana lymph noma ama-lymphocyte akhona kuzo zonke izitho zomzimba. Isikhumba kuyindlela ebalulekile yokuvikela amasosha omzimba, kanti amanye ama-T-cell ayafudukela esikhumbeni ukuvikela ukulwa nokutheleleka. Amangqamuzana omdlavuza we-T-cell lymphoma enezinwele nawo abuyele esikhumbeni. Eziningi zezici ze-CTCL zihlobene nezilonda, noma ukulimala, zikhiqiza esikhumbeni.
I-T-cell i-lymphoma encane ibonisa iqembu lezinhlobo ezingavamile ze-Non-Hodgkin Lymphoma (NHL). I-CTCL ibhalela kuphela iziguli ezingu-40 ezitholakale zitholakale ku-NHL.
Izingozi Zezingozi
I-CTCL ithinta amadoda ngokujwayelekile kunabesifazane. Abantu abane-CTCL bavame ukuthi bangamashumi amahlanu noma amashumi ayisithupha. Izingane azivame ukuthinteka. Kuye kwaba nokwanda okuphawulekayo kwenani labantu abathintekayo yesikhumba lymphoma kule minyaka engamashumi amathathu edlule.
Akuyona into eyaziwa kakhulu ngesisusa se-CTCL. Ngokungafani nezinye izinhlobo ze-lymphomas, ayikho inhlanganisela namagciwane aziwayo.
Ucwaningo luyaqhubeka ukuthola ukuthi yiziphi izimbangela ze-CTCL.
Izimpawu
Izimpawu zokuqala zesikhumba se-lymphoma zihlanganisa isikhumba esomile noma se-scaly, ama-red rashes, kanye nokushaya. Iziqhumane zivame kakhulu ezindaweni ezihlala zimbozwe izingubo. Abanye abantu bangase baqale babone izibomvu ezibomvu noma ezimnyama esikhumbeni. Lezi zimpawu azizona ezenzelwe i-lymphoma futhi abantu abaningi bavame ukuphathwa ngezimo zesikhumba ezivamile ngaphambi kokuba kucatshangwe i-lymphoma.
Njengoba lesi sifo sithuthuka, ama-patches abomvu angase aphakanyiswe, Lezi zikhonkwane eziphakeme ziyaziwa ngokuthi ama-plaque. Ama-plaque angase aphenduke ama-tumor nodular noma ama-bumpy. Ezifweni ezithuthukisiwe, izilonda zingathuthuka ngaphezulu kwalezi zilonda. I-CTCL ingase isakaze nakwezinye izitho zomzimba. Iningi labantu abane-CTCL kuphela banezimpawu zesikhumba. Amaphesenti angaba ngu-10 amacala asekupheleni kwesikhathi asethuthuka ekuthuthukiseni izinkinga ezinkulu.
Ukuxilongwa
I-biopsy yesikhumba iyadingeka ukuze ihlolwe i-CTCL. Isampula ye-biopsy izohlolwa ngaphansi kwe-microscope ukukhomba amangqamuzana e-lymphoma. Ezinye izivivinyo eziningi ezihlanganisa ukuhlolwa kwamakhamera e-lymphoma (immunohistochemistry) kanye namagciwane e-lymphoma kudingeka afune uhlobo lwe-lymphoma. Ucwaningo lwe-CT noma ezinye izivivinyo ze-imaging zingenziwa ukuze zifinyelele ubukhulu besifo.
Ukwelapha
Ukwelashwa kwesikhumba lymphoma kuhluke kakhulu endleleni ezinye izidakamizwa eziphathwa ngayo. Isu sakho sokwelashwa luyoxhomeka ekutheni libandakanye isikhumba, uhlobo lwesilonda sesikhumba, nokubandakanyeka kwamanothi noma ezinye izitho zomzimba.
Izinhlobo eziningi zokwelashwa zisetshenziswa:
- Ama-chemotherapy agents asetshenziswa esikhumbeni
- Ingqikithi yokwelashwa kwe-electron yeganda - uhlobo lokuphathwa kwemisebe
- I-Psoralen ne-ultraviolet A imisebe
- Imibala ye-Ultraviolet B
- I-Bexarotene - kokubili njengejel kanye namaphilisi
- Denileukin Difitox
- I-Interferon alpha
- I-Chemotherapy nge-injection noma amaphilisi
Iningi lwakamuva, i-US Food and Drug Administration (FDA) ivunyiwe i-mechlorethamine gel (Valchlor) ngenxa yokwelashwa kwesikhumba ye-mycosis fungoides, uhlobo oluvame kakhulu lwe-CTCL. Ngaphambi kokuvunyelwa kwayo, i-mechlorethamine yayivunyelwe kuphela ukwelashwa kwangaphakathi.
Izwi kusuka
Iqembu laseJurophu labahlanganyeli bezinhlangano lihlangane futhi lanyathelisa izincomo zabo zokwelapha izinhlobo ezahlukene ezahlukene kanye namacala e-CTCL, ekhomba ukuthi ukwelashwa okuqondiswa isikhumba kuseyindlela engcono kakhulu ye-stage-stage ye-mycosis fungoides, nokuthi iziguli eziningi ezine-mycosis fungoides zingabheka phambili esikhathini esijwayelekile sokuphila.
Ngeshwa, lesi sifo sisahlezi iziguli ezinezifo eziphambili, ziphawula ukuthi nakuba zikhona izigungu ezikhethiwe kakhulu zeziguli, ukusinda isikhathi eside kungatholakala nge-allogeneic stem cell transplantation (alloSCT).
Noma kunjalo, kwenziwa intuthuko enkulu eminyakeni eyishumi edlule ngokuqonda indlela i-mycosis fungicides ne-Sezary syndrome eqala ngayo, ngakho-ke kukhona ithemba lokuthi lokhu kuzoholela ekuthuthukiseni ukwelashwa kanye.
> Imithombo:
> Trautinger F, Eder J, Assaf C, et al. I-European Organisation for Research and Treatment of Cancer izincomo zokuvumelana ngokuphathwa kwe-mycosis fungoides / Sezary syndrome - Buyekeza 2017. I- Eur J Cancer. 2017; 77: 57-74.