Kungase kube nesisombululo esihle ekukhoneni kwakho okungapheli nokukhanda isikhumba
I-atopic dermatitis , eyaziwa nangokuthi i-eczema, iyisifo esivamile, esikhumbeni esikhulayo, esibangela ukuba isikhumba esibomvu, esinamahloni, esiphundu, nesinye isikhathi esikhulayo noma esikhulayo. Kuvame ukuqala ebuntwaneni kanti abanye abantu bangaphikelela ekukhuleni. Eqinisweni, ngokusho kwe-American Academy of Dermatology, cishe umuntu oyedwa kuya kwezingamaphesenti amathathu kubantu abadala emhlabeni jikelele banesifo se-atopic dermatitis.
Isizathu esicacile se-atopic dermatitis sisaphikisana futhi sifundwe, kodwa cishe kuhlanganisa ukusebenzisana okuyinkimbinkimbi phakathi kwamagciwane omuntu, amasosha omzimba omzimba, kanye nomsebenzi ongasebenzi kahle we-epidermis-uhlaka olungaphandle lwesikhumba somuntu.
I-atopic dermatitis ingasetshenziswa nge:
- Ukunakekelwa kahle kwesikhumba , kufaka phakathi ukunyakaza kwamanzi.
- Ukususwa kwezinto ezibangela kanye nezici ezikhulayo.
- Ukwelashwa kusetshenziswe esikhumbeni, njengezikhwama ze-steroid kadokotela namafutha.
Kodwa-ke, kwabanye abantu abadala abanesisindo esincane ngokweqile, isifo sabo asihambisani nemithi yokwelapha (noma abakwazanga ukuthatha lezi zindlela zokwelapha), ngakho-ke, injectable engangokwesimo esidinga izakhi ingadingeka.
I-Dupixent (i-dupilumab) yilapho i-FDA imithi yokwelashwa yokuqala neyodwa kuphela evunyelwe ukwelapha i-eczema enzima kubantu abadala. Ijova njalo emasontweni amabili emthonjeni noma emathunjini aphansi ngaphakathi kwezingqimba ezinamafutha ngaphansi kwesikhumba-lokhu kubizwa ngokuthi i-injection subcutaneous.
Izindaba ezinhle ukuthi udokotela wakho noma umhlengikazi angakufundisa noma othandekayo ukuthi anganikeza umjovo, ngakho-ke ungayenza ekududuzeni kwekhaya lakho. Kuyinto enhle ukuphawula ukuthi le mithi ingasetshenziswa ngokuhambisana nemithi yokwelashwa ye-steroid, noma ingasetshenziswa yodwa.
Yeka ukuthi i-Dupixent (i-dupilumab) isebenza kanjani
I-Dupixent (dupilumab) imithi ye-biologic, okusho ukuthi isebenza kuwo wonke umzimba ukuba ushintshe indlela amasosha omzimba wakho asebenza ngayo.
I-anti-monoclonal antibody-uhlobo lwe-antibody oludalwa ebhokisatri.
Uma ijojwe futhi ingena emgodleni wegazi, ibophezela kwisayithi elithile lokuqapha eligcina ukuvimbela isenzo sezinhlelo ezimbili zamaprotheni (i-interleukin-4 ne-interleukin-13). Lawa maprotheni ayaziwa ukuthi adlala indima enkulu ekwakheni ama-eczema patches.
Imiphumela ye-Dupixent (dupilumab)
Ucwaningo luveze hhayi ukuncipha kwendawo yomzimba kanye nobukhulu bezintambo ze- eczema kodwa futhi kunciphisa okukhulu ekuqotheni, okungahle kube nzima kakhulu kubantu abane-atopic dermatitis. Ngaphezu kwalokho, ngezigaba ezimbili zeviki eziyi-16, izidakamizwa zitholwa ukunciphisa izimpawu zokukhathazeka nokucindezeleka nokuthuthukisa ikhwalithi yokuphila.
Zikhona Yini Imiphumela Ebizayo Okumele Yayiqaphele?
Injectable ingabangela ukucasula isikhumba esakhiweni somjovo. Nakuba kungavamile, kungase kubangele ukusabela okubi kakhulu, kanye nezinkinga zamehlo ezinjengeyomile, iso lokubheka amehlo, iso elibomvu (elibizwa ngokuthi i- conjunctivitis ), i-eyisidi ukuvuvukala (okuthiwa yi-blepharitis), noma ukuvuvukala kwe-cornea (okuthiwa i-keratitis). Izilonda eziseduze noma ezungeze izindebe nasemlonyeni wonke (obizwa ngokuthi i- oral herpes ) nazo zibikiwe.
Kubalulekile ukuxhumana nodokotela wakho ngokushesha lapho ubhekana nezinkinga zombono, ubuhlungu beso, noma ukucasuka kweso.
Kubalulekile futhi ukuyeka ukuphatha imithi futhi ufune ukunakekelwa kwezokwelapha uma ubona izimpawu zokuzizwa okunomzimba njengama-hive, ukuqhuma isikhumba noma ngaphandle komkhuhlane, izilonda zesikhumba ezivuvukile, ubuhlungu obuhlangene, ukukhipha noma ukuzwa okuvamile. Yiqiniso, okukhulunywe ngenhla akuzona zonke imiphumela emibi engase ibe nayo umuntu, ngakho qiniseka ukuthi uxhumane nodokotela wakho nganoma yiziphi izinkinga noma izinkinga.
Okokugcina, abanye abantu bahlakulela izidakamizwa kumuthi, okwenzeka lapho umzimba ukhiqiza amaprotheni ukunciphisa noma ukuvimbela umphumela wayo wemvelo. Lokhu kungase kusolwe uma umuntu eyeka ukuphendula imithi, futhi angaqinisekiswa ngokuhlolwa kwegazi.
Yini Okufanele Ngiyitshele Udokotela Wami?
Khuluma nodokotela wakho mayelana nazo zonke izimo zakho zezempilo, ikakhulukazi uma unezinkinga zamehlo, ukutheleleka kwe-parasitic, noma i-asthma. Futhi, qiniseka ukuthi utshele udokotela wakho ukuthi ukhulelwe, uncelisa, noma uhlelwe ukuthola imithi. Ngenxa yemiphumela yesimiso somzimba sokuzivikela komuntu, kunconywa ukuthi akekho othayipha le mithi yokwamukela noma yimiphi imithi yokugoma (isibonelo, umgogodla we-intranasal noma i-zoster vaccine).
Kubalulekile futhi ukwabelana nodokotela wakho yonke imithi yakho, kuhlanganise nanoma yiziphi izidakamizwa ezingaphezu kwamandla, amavithamini, noma izithako.
Isithombe esikhulu lapha kufanele sikulungele uma uvakashela i-allergenist yakho. Ngokwenza kahle futhi ukwabelana nomlando wakho wezokwelapha nodokotela wakho, anganquma ukuthi lokhu kuyindlela efanele yokwelapha.
Izwi elivela
I-atopic dermatitis enamandla ingabangela ama-eczema ama-eczema amaningi emzimbeni, okungaba kokubili ukuphuza ngokomzimba nangokwengqondo. I-Dupixent (dupilumab) inikeza ithuba kulabo bantu abadala abaphethe izifo ezinzima kodwa abazange bathole ukusizwa abafanelwe nemithi yokwelapha ejwayelekile njengama-steroid creams namafutha. Ngaphezu kwalokho, kubonakala sengathi kuphephile, nakuba ingozi eyengeziwe yezinkinga zamehlo idinga ukukhishwa ngaphezulu.
Lokhu kuthiwa, le mithi ayiyona yonke into, futhi ngalesi sikhathi, igcinelwe kulabo abangenakho okunye okukhethwa kukho. Hlala ebhodini njengoba ucwaningo luqhubeka luguqukela kwi-biologics ye-injection ye-eczema.
> Imithombo:
> I-American Academy of Dermatology. I-Atopic Dermatitis: Ubani Otholayo Nezizathu.
> Beck LA et al. Ukwelashwa kwe-Dupilumab kubantu abadala abane-atopic dermatitis. N Engl J Med . 2014 Jul 10; 371 (2): 130-9.
> Simpson EL et al. Izivivinyo ezimbili zesigaba se-Dupilumab ngokumelene ne-placebo e-atopic dermatitis. N Engl J Med . 2016 Dec 15; 375 (24): 2335-2348.
> Spergel JM. (February 2015). Ukuphathwa kwe-atracic dermatitis enamandla kakhulu (eczema). Ku: UpToDate, Dellavalle RP (Ed), UpToDate, Waltham, MA.
> Ukuphathwa Kwezokudla Nezidakamizwa zase-US. (Mashi 2017). Okuqukethwe Okuphelele : Okuxubileyo .