I-arthritis ye-rheumatoid , isifo esizimele esithinta izigidi ezingama-1.3 kuya ku-1.5 eziMelika, umphumela wamasosha omzimba omzimba ahlasela isifo somzimba kanye namalungu. Yini empeleni ihamba nge-haywire ohlelweni lomzimba lomuntu one-arthritis ye-rheumatoid ukuze abange ubuhlungu nokubhujiswa okuhambisana nesifo?
Izifundo ezenziwa nguDkt. Julia Ying Wang weBrigham & Abesifazane Isibhedlela eBoston naseHarvard Medical School, kanye nosebenza naye uDkt. Michael H.
I-Roehrl yaseHarvard, yanikezwa emhlanganweni waminyaka yonke we-American Chemical Society ngo-Agasti 2002 futhi yanyatheliswa ku- PNAS, ukubhekana nalo mbuzo.
Ngaphambi komsebenzi kaWang noRehrl, ucwaningo lwe-arthritis lwama-rheumatoid lwalugxile kakhulu kuma-peptide, noma izingcezu zamaprotheni. U-Wang no-Roehrl basikisela ukuthi ama-glycosaminoglycans, noma ama-GAG, yilokho okubangela i-arthritis ye-rhumumayidi kunokuba amaprotheni.
I-GAGs Theory
I-Glycosaminoglycans i-carbohydrate evela ngokwemvelo etholakala ku- cartilage , izicubu ezixhumeneyo , iziqu ezihlangene nezikhumba. I-Glycosaminoglycans yi-carbohydrate eyinkimbinkimbi. Abathintekile yi-carbohydrate, amazinyo, noshukela esiwadla ekudleni kwethu.
Ngokusho nje, inkolelo kaWang yaphakamisa ukuthi amasosha omzimba omzimba, noma ama-antibodies, ahlose i-glycosaminoglycans. I-antibodies ibophezela ku-GAGs, iqoqa ngamalunga, futhi ibangela ubuhlungu nokuvuvukala okuhlobene nesifo samathambo.
Ucwaningo
Esifundweni sikaWang noRohrl, amagundane ayejojowe namaGAG.
Amagundane ahlakulela izimpawu ezinjenge-arthritis ezinjenge-rheumatoid, ezihlanganisa ukuvuvukala, ukuvuvukala, kanye nethambo.
Amagciwane e-Glycosaminoglycan aselokhu atholakala emathanjeni weziguli zesifo se-rheumatoid arthritis. Kumele kugcizelelwe ukuthi lokhu kwakuyi-anti-glycosaminoglycan antibodies okokuqala okuye kwabonwa yizilwane noma abantu.
Abacwaningi bathi:
- Amagciwane we-GAG angathuthuka ngenxa yokutheleleka kwebhaktheriya.
- Amazinga aphezulu we-GAG angabangela uma amabhaktheriya enza ama-enzyme aphula izicubu ezixhumeneyo futhi akhiphe ama-carbohydrate.
- Ama-bacteria amaningi aneGAG esitokisini. Ku-arthritis ye-rheumatoid, amangqamuzana omzimba angase aqondise ngokungalungile ama-GAG angokwemvelo emathanjeni omzimba ngendlela efanayo abazoyikhomba ngayo i-GAG ebusweni bomhlaseli bebhaktheriya.
Abacwaningi babe nethemba lokuthi ezinye izifundo ziyoveza indlela yokubopha ama-anti-gaga, okuholela ekunakekeleni okusha noma imithi ye-arthritis ye-rheumatoid. Ucwaningo olunyatheliswa ngo-2008, ku- Arthritis Research & Therapy , lwembule kabanzi nge-GAGS:
- Ama-antibodies aqondene ne-GAG akatholakali kuma-neonates (amantana).
- Ama-GAG akhona ngamanani aphezulu kuseva yabantu abadala.
- Ama-GAG aye ahlukaniswe njengezi-antigens ze-TI2. Amaseli e-B1 B ayaziwa ukuthi ayasebenza ngama-antigens we-TI2.
Kwaphinde kwavezwa ukuthi amasosha omzimba we-anti-GAG angama-autoantibodies angokwemvelo atholakala kubantu abanobuhle. Ama-antibodies we-IgM anti-GAG namanye ama-IgG-anti-GAG antibodies ahlolwe atholakala ukuthi aphakanyiswe kakhulu ku-sera yeziguli ezine-arthritis ye-rheumatoid. Ngesikhathi ama-anti-GAG antibodies ekhona ohlelweni lwe-systemic, i-synovial fluid futhi nayo ikwazi ukubophezela kumatrix we-extracellular we-hyaline cartilage.
Abacwaningi bacabanga ukuthi ukukhiqizwa kwama-anti-GAG okuphikisana nomzimba "kuphakanyisiwe" ku-arthritis ye-rheumatoid mhlawumbe ehlobene nokukhululwa kwama-molecule we-cartilage. Ngokuthakazelisayo, amazinga aphezulu e-anti-GAG ahlotshaniswa nesifo esincane kakhulu esihlokweni se-rheumatoid arthritis. Abacwaningi baphetha ngokuthi ama-GAG angasebenza njengesifo se-biomarker sokuqala se-rheumatoid arthritis.
Imithombo:
I-Glycosaminoglycans Yimbangela Eyinhloko Ye-Arthritis Ye-Rheumatoid. Izinqubo ze-National Academy of Sciences yase-United States of America. U-Wang JY no-Roehrl MH. Ngo-Okthoba 21, 2002.
Ama-autoantibodies ezingokoqobo asebenzisana ne-Glycosaminoglycans ku-Arthritis ye-Rheumatoid. Bence Gyorgy et al. I-Arthritis Research & Therapy. 2008.