Phakathi Kwezilingo Zokuqala Ezibekiwe Uma I-Arthritis Ye-Rheumatoid Isolakala
Isisindo se-rheumatoid i-autoantibody (ngokuvamile i-IgM) ebopha esifundeni seFc sama-IgG antibodies. Ama-autoantibodies ama-protein asekhiqizwa amasosha omzimba , kodwa kunokuba ahlasele izinto zangaphandle, ahlasela izicubu zomzimba. Uma udokotela wakho esolwa ukuthi ungaba nesifo samathambo , ukuhlolwa kwesici se-rheumatoid cishe kuzoba phakathi kokuhlolwa kokuqala kokuhlola.
Izilinganiso zokuqala (izivivinyo) ukuphakamisa ukuthi ama-autoantibodies ahlotshaniswa ne-arthritis ye-rheumatoid yasungulwa ngawo-1940. Ekuqaleni, lokhu kwakuyizivivinyo ze-agglutination lapho kubonakala khona i-serum evela ezigulini ze-rheumatoid arthritis okwenza ukuba i-agglutination yezimvu ezibomvu zamangqamuzana egazi ezazisetshenziselwa ukwelashwa kwe-rabbit anti-sheep erythrocyte. Kwakukhona ukushintshwa okwenziwe okwenziwe ekuqaleni kokuhlolwa kwe-agglutination, ngokuyinhloko ukufaka ubuhlalu be-lateg obugcwele nge-IgG yamaseli ezimvu. Ekugcineni, kuhlolwa isilwane se-ELISA (test-immunosorbent assay) esihlotshaniswa ne-enzyme) kanye nokuhlolwa kwe-nephelometry.
Ekuhlolweni kwe-agglutination, ukuhlanganiswa kubonisa imiphumela emihle. Ukunwetshwa kwe-serial kungenziwa ngesampula yokuhlola ukucacisa isihloko. I-titer ibonisa ukuthi isampuli ingahlungwa kanjani ngaphambi kokuthi isifo se-rhumatoid singabonakali (asihlanganisi).
Ekuhlolweni kwe-nephelometry, isampula yegazi ixubene nama-antibodies okubangela ukuqhuma.
Ukukhanya kudluliselwa ngesampula ukucacisa izinga lefu.
Ukuqonda Imiphumela
Ngokuvamile, uhla olujwayelekile lwesilingo se-rheumatoid factor lubikwa ngokuthi:
- Ngaphansi kuka-40-60 u / mL
- Ngaphansi kwe-1:80 (isihloko)
Qaphela: Ama-laboratories ahlukene angashintsha endleleni yokuhlola noma isitifiketi sokuhlola esetshenziswayo, ngakho landela imiphumela kanye nobubanzi obuvamile obuhlinzekwa yi-laboratory yakho ethile.
Imiphumela ye-test factor ye-rheumatoid ingadida iziguli ze-arthritis. Okokuqala futhi okubaluleke kakhulu, into ebaluleke kakhulu ukwazi ukuthi ukuhlolwa kwesici se-rheumatoid kuyisici esisodwa semininingwane esetshenziselwa ukudala ukuxilongwa. Ukuxilongwa okuqinisekisiwe akukaze kusekelwe kuphela emphumela wokuhlolwa kwesici se-rheumatoid. Nanka amanye amaqiniso abalulekile mayelana nokuhlolwa kwesici se-rheumatoid okufanele ukwazi:
- Isifo se-rheumatoid singaba nomuntu onempilo (ku-1% wabantu abasha futhi kufinyelele ku-5% kulabo abangaphezu kweminyaka engu-70 ubudala).
- Isifo se-rheumatoid singaba nesifo esihle kunezifo ze-arthritis ezingezona i-rheumatoid nezimo (isb., Ukutheleleka, umdlavuza) noma ezimweni ze-rheumatic ngaphandle kwesifo samathambo (isib. Sjogren's syndrome noma lupus ).
- I-factor rheumatoid ingatholakali egazini kuze kube yiminyaka engu-10 ngaphambi kokuba izimpawu zesifo samathambo zivele. Noma kunjalo, kwesinye isigungu seziguli ze-rheumatoid arthritis, i-rheumatoid factor iyatholakala ngemva kokuba izimpawu zivele.
- Iziguli ze-rheumatoid arthritis ezitholakala ngesifo se-rheumatoid (i-seropositive) zivame ukuba nesifo esinamandla kakhulu, kuyilapho iziguli ezingenayo isifo se-rheumatoid (i-seronegative) zinesifo esincane kakhulu nezinkinga ezimbalwa zamathambo.
- Abantu abangaba ngu-20% abathintekayo abane-arthritis ye-rheumatoid bahlala bengenayo isifo se-rheumatoid phakathi nenkathi yesifo sabo.
Ukubaluleka Kwemitholampilo Yemiphumela
Umphumela wokuhlola wezinto eziphathelene nesifo se-rheumatoid okungenayo ingalungile ngokuhamba kwesikhathi ungahle uphenduke, kodwa ukuhambisana komtholampilo kwaleli qiniso kuhlale kungabhekwa. Ngokusho kukaScott Zashin, MD, isifo se-rheumatologist esivela eDallas, eTexas (scottzashinmd.com) nomlobi we- Arthritis Without Pain - The Miracle of TNF Blockers kanye nombhali-mbhali wencwadi yami yesibili ye- Natural Arthritis Treatment , "Ngokuvamile ama-Rheumatologists awahambisani ne-rheumatoid factor lapho kutholakala ukuthi i-arthritis ye-rheumatoid ishicilelwe. Lokhu kuthiwa, ekuhlangenwe nakho kwami, izinga le-rheumatoid lingase lishintshe ngandlela-thile ngemisebenzi yesifo , kodwa lokho akusiyo emtholampilo efana nezinye izivivinyo, njengezinga le- sedimentation le- erythrocyte , i- C- amaprotheni asebenzayo (CRP) , futhi kwezinye izimo ezinye izimpawu ezingatholakala ezivivinyweni ze-VECTRA , ezisetshenziselwa ukuhlola umsebenzi wesifo ku-arthritis ye-rheumatoid. "
Imithombo:
I-Kelley's Bookbook of Rheumatology. I-Ninth Edition. Ama-autoantibodies ku-Rheumatoid Arthritis. Isahluko 56. Felipe Andrade et al. p. 804.
I-Primer kuma-Rheumatic Diseases. Umshicileli weshumi nantathu. Ishicilelwe yi-Arthritis Foundation. Isahluko 6. I-Rheumatoid Arthritis. Izimo ze-Rheumatoid. p. 126.
I-Rheumatoid Factor (RF). I-MedlinePlus. Kubuyekezwe 4/20/2013.
https://www.nlm.nih.gov/medlineplus/ency/article/003548.htm