I-foot foot-syndrome ngesikhathi se-chemotherapy
I-Hand-foot syndrome (i-HFS), eyaziwa ngokuthi i-palmar plantar erythrodysesthesia, ingumphumela we-dermatological side side of some chemotherapy kanye nemithi yokwelashwa kwezinto eziphilayo. Ngokuyinhloko kuthinta izintende zezandla nezinyawo ezinyaweni. I-HFS iyenzeka lapho inani elincane lemithi livuza ngaphandle kwamapillari futhi kubangele ukulimala kwezicubu ezibonakalayo. Abantu abaningi abane-HFS bathuthukisa imiphumela emnene, kodwa abanye bangabhekana nemiphumela emibi, ukwenza imisebenzi yokuphila yansuku zonke kungeke kwenzeke.
I-Chemotherapy ne-Targeted Therapy Izidakamizwa Okungahle Kubangele Isisindo Sama-Hand-Foot
I-foot foot syndrome ivame ukuhlotshaniswa nezidakamizwa ze- Xeloda (capecitabine) *. Ezinye izidakamizwa ezaziwa ukudala isifo sonyawo zihlanganisa:
- I-5-FU (i-fluorouracil) *
- I-Cytosar-U (i-cytarabine)
- I-Adriamycin (doxorubicin) - ukumnika okuqhubekayo
- I-FUDR (floxuridine)
- I-Doxil (i-liposomal doxorubicin)
- Idamycin (i-idarubicin)
- I-Nexavar (iSorafenib)
- I-Sutent (i-Sunitinib)
Khumbula ukuthi akubona bonke abantu abathatha lezi zidakamizwa zomdlavuza bazokwakha i-foot foot syndrome.
* Ukuntuleka kwe-Dihydroprimidine dehydrogenase (i-DPD) - ukuba neqoqo elihlukile lama-enzyme engokwemvelo kunokwejwayelekile - yinto ejwayelekile yeHFS ejulile futhi esheshayo eyenzeka ngokusetshenziswa kwezidakamizwa. Ngokuvamile kuhambisana nohudo olunzima. Abantu abangaba ngu-5% baseMelika banalutho. Ukuvivinywa akuyona isimiso, kodwa udokotela wakho angenza kanjalo uma udinga ukuthatha enye yalezi zidakamizwa.
Izimpawu Ze-Hand-Foot Syndrome
Izimpawu ezivamile ezihambisana ne-foot-foot syndrome zifaka:
- Ukulinganisa noma ukuphazamiseka
- Ukuvutha
- Ukubomvu
- Ukuvuvukala
- Ububele
Ezimweni ezinzima zesifo sonyawo, isikhumba singase siqale ukuphuma noma senze izilonda noma izilonda. Emile, isikhumba esikhanyayo esingahle noma esingasiboni singaba khona. Lokhu kungathinta kakhulu izinga lomuntu lomuntu, ikakhulukazi ikhono lakhe lokuhamba nokusebenzisa izandla zakhe.
Ezilingo zomtholampilo, cishe amaphesenti angu-5 kuya ku-10% wabantu abhekana nalezi zindlela zesifo sonyawo.
Ukulahlekelwa kwamafingerprint kanye neSynder-Foot Syndrome
Ukulahlekelwa kwamafingerprint kuye kwahlotshaniswa nokusetshenziswa kwezidakamizwa zomdlavuza ezibangela isifo sonyawo . Lo mphumela wecala ongavamile ungacatshangwa ukuthi uhlobene nobude besikhathi lapho kuthathwa khona izidakamizwa. Ukucubungula nokuphungula isikhumba ngokuhamba kwesikhathi kungabangela ukuthi izigxivizo zeminwe zisuswe. I-foot-foot syndrome yazuza ukunakwa kwamaphephandaba ngo-2009 lapho indoda yaseSingapore iboshwe e-US Customs ngokungenayo iminwe yeminwe. Isimo sakhe sasihlobene nokuthatha i-Xeloda (capecitabine) iminyaka emithathu.
Ukuvimbela nokuphatha i-Hand-Foot Syndrome
Ukuvimbela kuyisihluthulelo ne-HFS. Ukushisa nokukhathala yizici ezimbili ezidambisa ukuvuza kwe-capillary. Ngempelasonto emva kokunikezwa imithi ye-IV, noma yonke inkathi uthatha imithi yomlomo yomuthi, kunezinyathelo eziningana ongayithatha ukuze usize ukuvimbela nokuphatha i-HFS:
Gwema Amanzi Ashisayo - Ukuveza isikhumba emanzini ashisayo isikhathi eside (ukuthatha ibhati lokugeza nezibhakabhaka, isibonelo), ukuwasha, nokuphumula emhubheni wokushisa akukhuthazwa. Ukuthatha isisindo esiphuthumayo noma esifushane kungcono ngesonto ngemuva kokuthatha imithi ye-IV noma ngesikhathi sokuthi uthatha imithi yomlomo.
Amagilavu we-Rubber awahlinzeki ukuvikela - empeleni ashisa izandla. Udokotela wakho angase futhi ancoma ukuthi ungathathi ngokushisayo ishazi noma ukugeza amahora angu-24 ngaphambi kokwelashwa.
Gwema Ukuzivocavoca Nomsebenzi Wezincwadi - Ukuzivocavoca okubeka ukucindezeleka okuningi nokucindezeleka ezandleni nasezinyaweni, njengokuthi i-aerobics, ukuhamba isikhathi eside, ukugijima, nokugcoba umzimba (ngisho namagilavu), kufanele kugwenywe. Umsebenzi wezandla njengengilazi kanye nomsebenzi wegceke kufanele futhi ugwenywe.
Gqoka izingubo ezifanelekayo zokugqoka - Izambatho zokugqoka nezicathulo zingabangela ukungqubuzana, ngaleyo ndlela kuholela ekwenzeni ukuvuza kwe-capillary. Gqoka izicathulo ezikhululekile ezinama-cushioned soles.
Ungahambi ngezinyawo ezingenalutho; amasokisi okotini noma ama-slippers athambile ahamba phambili.
Ungagqoki izintambo - Ukuze unciphise ukuqhuma, gwema ukugqoka amasongo eminwe yakho. Izindandatho ezingakaze zisuswe, njengezindandatho zomshado, zingaba umthombo wamabhaktheriya kanye. Ama-bacteria angabanjwa phakathi kwendandatho nomunwe. Ukuvimbela ukutheleleka nokulawula kubaluleke kakhulu nge-HFS ngenxa yobuzwe besikhumba.
Gcina Amandla Nezinyawo Ukuphumula - Kuzo zonke izinsuku, sebenzisa amaphakethe e-ice noma ukuphoqa ukuphoqa izandla nezinyawo. Ukuzifaka emanzini izikhathi ezimbalwa ngosuku nakho kuyasiza.
Faka isicelo se-Emollients - Ama- Emollients angama-moisturizers akhethekile aphuza isikhumba esomile, esiqhekekile nesicasulayo . Odokotela abaningi batusa imikhiqizo emollient efana ne-Aveeno ne-lanolin, i-Lubriderm, i-Udder Cream, i-Bag Balm, ne-Aquaphor. Ungasebenzisa ama-emollients izikhathi eziningana ngosuku, kodwa qiniseka ukuthi ungagcoki isikhumba ngengcindezi enkulu. Ukugqoka amasokisi namagilavu emva kokusebenza kuzosiza ukubamba umswakama.
Hlala Uhlelwe Ngokwemvelo - Ukuphelelwa amandla kwamanzi nakho kuyimbangela yesikhumba esomile, ngakho-ke kubalulekile ukugcina kahle amanzi ngokuphuza amanzi amaningi. I-Caffeine iyimbangela eyaziwayo yokuphelelwa amandla kwamanzi futhi kufanele igwenywe.
Indlela Udokotela Wakho Angaphatha Ngayo Isandla Sama-Syndrome
Amacala amancane we-HFS angeke adinge ukungenelela kwezokwelapha, ngokuqapha okucophelela wena nomhlengikazi nodokotela wakho. Uma uqala ukubona noma yiziphi izimpawu ze-HFS, shayela unesi noma udokotela wakho oncology . Uma uhlushwa yi-HFS futhi uqaphela ukuthi kubi kakhulu, kubalulekile ukubiza udokotela wakho ngokushesha.
Izimo ezinzima zesifo samandla ezinyawo eziphazamisa imisebenzi yokuphila yansuku zonke kubhekwa njengenkinga enkulu yokwelashwa, futhi iphathwa njengenjalo. Ukunciphisa ukwelashwa noma ukwehlisa umthamo kungadingeka. Imithi ye-OTC yobuhlungu efana ne-ibuprofen inganconywa ukuze ikhululwe ubuhlungu. I-corticosteroids yomlomo noma yomlomo ingasiza abanye ngokuvuvukala. I-celebrex (celecoxib) ye-medicinal non-steroidal anti-inflammatory (i-cerecoxib) ayilungile ngokusekelwe ekubuyekezweni kwezifundo.
Amanani aphezulu ka vithamini B6 avame ukunconywa kubantu abangase bahlakulele i-HFS noma sebevele behlupheka ngakho. I-oncologists ivame ukuphakamisa ukusetshenziswa kwesikhathi esifushane kwe-50 kuya ku-150 mg ye-B6, ephakeme kakhulu kunezincomo zansuku zonke. Ukuhlaziywa kwe-meta ka-2015 - ukubuyekezwa kwezifundo ezishicilelwe kuze kube yimanje - kwahluleka ukuthola ukuthi i-vitamin B6 empeleni yasiza nge-foot foot syndrome, kodwa abantu ababona izibalo futhi kungenzeka ukuthi abanye abantu banokuthuthukisa izimpawu. Njalo uthintane nodokotela wakho ngaphambi kokuthatha i-vitamin B6 ye-HFS. Amanye ama-vitamin nama-mineral supplements anganciphisa ukusebenza kwe-chemotherapy .
Ucwaningo oluningi luqhutshwa mayelana nokuvimbela nokuphathwa kwe-foot foot syndrome. Indima yama-nicotine, ama-henna, ne-vitamin E aphakathi kwezinto eziningi ezifundelwa ukukhululeka kwe-HFS.
Imithombo:
Hoesly, F., Baker, S., Gunawardane, N., noJ. Cotliar. I-hand-foot syndrome eyenziwa yi-Capecitabine yinkimbinkimbi ye-pseudomonal superinfection okubangelwa ukuthi i-bacterial sepsis nokufa: umbiko wesimo nokubuyekezwa kwezincwadi. I-Archives of Dermatology . 2011. 147 (12): 1418-23.
Jo, S., Shin, H., Jo, S. et al. Ukuphumelela kwe-prophylactic kanye nokwelapha kwamaphilisi e-pyridoxine ekuphathweni kwe-hand-foot syndrome ngesikhathi samakhemikhali: i-meta-analysis. Dermatology Clinic and Testing . 2015. 40 (3): 260-70.
IMakedoniya, uL., uLima, J., dos Santos, L., no-A. Sasse. Amasu okuvimbela i-hand-foot syndrome eyenziwa yi-chemotherapy-induced-foot-syndrome: ukubuyekezwa okuhlelekile nokuhlaziywa kwe-meta-analysis yezinkinga ezizokwenziwa ngamarandi. Ukondla Ukusekela Ekhanda . 2014. 22 (6): 1585-93.
McLellan, B., Ciardiello, F., Lacouture, M. et al. I-Regorafenib-ehlangene nesandla sesikhumba ukusabela: iseluleko esiwusizo ekuxilongweni, ekuvimbeleni nasekuphathweni. Amanothi we-Oncology . 2015. 26 (10: 2017-26.