Izingxenye ezintathu eziyinhloko zesimiso sezinzwa yilona uhlelo oluyisisekelo senzwa (ubuchopho nentambo yomgogodla), isimiso sezinzwa zomzimba (izingcingo nezitho zomzimba), kanye nesistimu ye-neon autonomic (uhlelo lokulawula, ukulondoloza i-homeostasis emzimbeni). Indima ye lupus ohlelweni lwezinzwa ezizimele lihlala lingacacile.
Kulesi sithombe esibukeziwe, sizogxila ikakhulukazi ohlelweni lwezinzwa zomphakathi futhi ezinye izindlela lupus zithinta uhlelo.
I-Central Central Nervous System
Imiphumela ye-lupus kwisistimu yezinzwa ezisemkhatsini iyabanzi. I-Lupus ingabangela izinkinga eziningi zesistimu yezinzwa, kufaka phakathi, kodwa kungagcini, ukungasebenzi kahle, ukuhlukunyezwa, ukushaywa kanye nokukhanda ikhanda. Lezi zinkinga zingase zihlotshaniswe ne-vasculopathy (isifo esithinta imithwalo yegazi), i-autoantibodies, isheshe isifo se-cardiovascular and molecules ezivuthayo. Iziguli ze-Lupus zingase zihlakulele isimiso somsakazo se-vasculitis.
Isistimu ye-central cervical vasculitis (CNS vasculitis) ichaza ukuvuvukala kobuchopho nemithambo yegazi lomgogodla futhi kungenzeka ukuthi iyinkimbinkimbi enkulu kunazo zonke ezihlobene ne-systemic lupus erythematosus (SLE). Ukutholakala kwalo njengesifo esiyisisekelo kuncane kakhulu kunokuthi kwenzeke njengesifo sesibili, njengokungathi yi-SLE.
Izibonakaliso ze-vasculitis yesimiso esisemkhatsini zihlanganisa ama-fever high, ukuhlukunyezwa (isikhathi esisodwa noma okuphikisanayo), ukucindezeleka kwengqondo, ukuqina kwentamo, kanye nezinhlungu ezinzima ezingaphenduli ukwelashwa okuvamile.
Ukuhlukunyezwa nokushaywa komzimba kungase kuvele ngokuzimela ngaphandle kwe-vasculitis futhi kungahle kuhlobene nama-autoantibodies okwandisa ingozi yokushaya isisu.
I-CNS vasculitis inzima ukuyihlolisisa futhi ngezinye izikhathi ibhekwa njengokuxilongwa okuvela ngomzamo weqembu. Izivivinyo eziningi, ezifana ne-CT (computed tomography), i-MRIs (i-imagination magnontic resonance), kanye namasampuli e-spinal fluid inikeza izinkomba ngaphezu kokuqaphela ukuxilongwa.
Lena incazelo ejwayelekile kakhulu, kodwa uma sekutholakala ukuthi, odokotela bangaphatha i-vascularitis ye-CNS yangempela ngokuhlanganiswa kwamazinga aphezulu e- corticosteroids ne-cyclophosphamide, enikezwe esibhedlela.
Abantu abangaba ngu-10% bazo zonke iziguli ze-lupus bangabhekana nale fomu ye-vasculitis futhi yilo kuphela uhlobo lwesifo sesishukela esisemkhatsini esifakiwe ku-American College of Rheumatology criteria yokuchaza i-SLE.
Ukungasebenzi kahle kwengqondo
Iziguli ze-Lupus zingazizwa zididekile, ngamanye amaphuzu empilweni yazo, zinzima ukuziveza zona, futhi zithole ukukhubazeka komemori, konke okuhambisana nesifo sabo. Ngokubambisana, lezi zibonakaliso nezimpawu zibhalwa njengokungasebenzi komqondo . Isizathu sokuthi bahlotshaniswa ne-lupus asiziwa.
Izimpawu ezihambisana nokukhubazeka kwengqondo ngokuvamile zilawulwa ngama-antimalarials noma ama-corticosteroids. Okunye ukwelashwa kokuziphatha kungase kube usizo.
Izinwele
I-lupus ehlobene nekhanda ifana ne-migraines ngokuqina kwayo futhi iphathwa ngokufanayo. I-Corticosteroids ingasiza futhi.
I-Fibromyalgia
Kulinganiselwa ukuthi cishe abangaba ngu-20% kulabo abahlukunyezwa yi- SLE nabo bane-fibromyalgia, isifo esibangela ubuhlungu be-muscle nokukhathala ezindaweni ezithile zomzimba, njengentamo, amahlombe, emuva, izilenge, izingalo nemilenze.
Babizwa ngokuthi "amaphuzu wethenda" ngoba banethando lokuthinta. Lokhu kuvame ukuphathwa ngemithi yokwelapha kanye nokwelashwa ngokomzimba, kanti imiphumela yomzwelo yenkinga iphathwa ngokucindezeleka kanye nokweluleka.
Okuthi Udokotela Wakho Ufuna Ukukwazi
Kubalulekile ukuvumela udokotela wakho ukuba azi ukuthi uhlangabezana nanoma yiziphi izimpawu noma izimpawu ezingase zihlotshaniswe nesimiso sezinzwa. Udokotela wakho uzofuna ukucacisa isizathu esiqondile.
Angenza izivivinyo eziningi, kufaka phakathi ukuhlola ngokomzimba kanye nokuhlolwa kwelabhoratori, okungabandakanya umsebenzi wegazi nokuvuselelwa komzimba. Izivivinyo ezicacile ekunqumeni nasekutholeni ukubandakanyeka kwesistimu yezinzwa ku lupus zihlanganisa:
- Isilinganiso se-Sedimentation, ukuhlolwa kokuhlola okungabonakali okungaqondile ngokuqondile ukuthi ukuvuvukala okuningi emzimbeni.
- Isivivinyo se-ANA (antinuclear antibody), esichaza i-autoantibodies ehlasela izicubu zomzimba namaseli.
- Ukuhlolwa kwe-Anti-DNA, okuqinisekisa ukuthi kunezinhlobo zokulwa namagciwane ezikhiqizwa ezakhiweni zofuzo esitokisini.
- Anti-ribosomal P antibodies test.
- Ukugcwalisa, ukuhlolwa kwegazi okulinganisa umsebenzi wezinhlelo ezithile zamaprotheni engxenyeni egazini yegazi lakho.
Udokotela wakho angase aqhube uchungechunge lwezivivinyo ze-neurological ezifana ne-CT, SPECT (i-single photon emission tomuted computed tomography) noma i-MRI, i-electroencephalogram, umgogodla wokugaya umgogodla (ukuhlola amangqamuzana, izingxenye zamaprotheni, kanye nama-antineuronal antibodies), noma i-PET (positron emission scan).
Ukwelapha
Imithi eqondile ibonakala ngaphansi kwezigaba ezingenhla, kodwa kufanele kuqaphele ukuthi impendulo yokwelapha ngayinye iqhuba i-gamut ibe yindabuko ukuze iphume kancane. Kodwa iningi, ukubandakanyeka kwesimiso sezinzwa kuguquke ngokuphelele.
Imithombo:
> Uhlelo Lokukhathazeka. Lupus Foundation of America. Januwari 2008.
> Iyini i-Vasculitis ?. I-National Heart, i-Lung ne-Blood Institute. Agasti 2006.
> Okufanele Ukwazi NgeSistimu Ephakathi Yezinzwa I-Vasculitis. Umtholampilo waseCleveland. Umnyango weRheumatic and Immunologic Diseases. Okthoba 2006.
> Amaqiniso Okusheshayo mayelana ne-Fibromyalgia. I-National Institute of Arthritis neMisculoskeletal kanye Nezifo Zesikhumba.