Kuyini i-Lupus Anticoagulant?

Le-antibody ingakufaka engozini yezindwangu zegazi

I-Lupus anticoagulant (LA) i-antiphospholipid antibody etholakala kubantu abaningi abane-lupus. I-Lupus anticoagulant ikwandisa ikhono lakho legazi lokugqoka. Ngakho-ke, uma une-antibody, unengozi enkulu yokuthola i- clot yegazi . Awudingi ukuba ne-lupus ukuze ube ne-LA.

Ngokusho kukaJohn Hopkins Center Lupus, amasosha omzimba we-antiphospholipid angama-antibodies aqondiswa:

Cishe amaphesenti angu-50 abantu abane-lupus bane-antiphospholipid antibodies. Amanqamuzana e-Antiphospholipid aphazamisa umsebenzi ojwayelekile wemithambo yegazi futhi angaholela ekunciphiseni kwemithwalo yegazi noma ama-blood clots. Lezi zinkinga zingabangela ukushaywa yisifo , ukuhlasela kwenhliziyo nokukhulelwa kwesisu.

Akukhona njalo okuhlobene ne-Lupus

I-antiphospholipid antibody lupus anticoagulant yatholwa kuqala kwiziguli zesistimu lupus erythematosus kuma-1940. Namuhla, odokotela bayaqaphela ukuthi i-LA iphinda ivele kubantu abanezinye izifo ezizimele (njengesifo sokuvuvukala kwesifo sofuba), izifo ezithile nezifo, kanye nabantu abaphuza imithi ethile, kuhlanganise ne-phenothiazines, i-phenytoin, i-hydralazine, i-quinine, noma i-antixictic amoxicillin .

Igama le-lupus anticoagulant lidukisa ngoba libonisa ukuthi i-antibody iyakhula ukuphuma kwegazi.

Eqinisweni, i-lupus anticoagulant isisiza igazi ukuba livale. Eqinisweni, cishe amaphesenti angu-50 we-lupus iziguli ezine-lupus anticoagulant zizohlangana ne-blood clot esikhathini esiyiminyaka engamashumi amabili ubudala, okwenza ukuba khona kwaleli antibody kube yingozi.

Uma une-lupus anticoagulant, kufanele uqaphele ngokukhethekile izimpawu nezimpawu ze-clot yegazi kuhlanganise:

Ukuhlolwa kwe-Lupus Anticoagulant

Ukuhlolwa kwe-coagulation, okukala ukuthi kuthatha isikhathi eside kangakanani igazi ukugqoka, lisetshenziselwa ukuthola i-lupus anticoagulant. Odokotela ukwelapha iziguli ze-lupus bavame ukuqala nge-coagulation test ebizwa ngokuthi i-thromboplastin ye-partial esebenzayo (aPTT) esebenzayo.

Uma imiphumela ye-aPTT ingavamile, odokotela bazosebenzisa ukuhlolwa okubucayi ukuze baqiniseke. Ngokuvamile, lena yesikhathi sokuhlunguphazeka kwesibungu sikaRussia (RVVT), esisebenzisa i-phospholipid nesifo kusuka enyoka yenyoka kaRussell ukuthola i-lupus anticoagulant. Ezinye izivivinyo ze-coagulation ezibucayi ezingase zisetshenziswe inqubo ye-platelet neutralization (PNP) kanye ne-kaolin clotting time (KCT).

Ukuvimbela izambatho zegazi

Abantu abavivinya ama-LA bavame ukushiwo abahlinzekeli begazi ukuze basize ukuvimbela ama-clots, kodwa kuphela lapho ukuvala okungavamile kuvela khona. I-Steroids ingase ibekwe ukuba ibasize ekunciphiseni amazinga e-antibody.

Ngendlela yokwelapha efanele, izinkinga ezivela ku-lupus anticoagulant ziyaphathwa.

Kunezinye izinto ongazenza ukuze uvimbele ama-clots wegazi uma une-LA:

Uma ukhathazekile ngezindwangu zegazi, khuluma nodokotela wakho nge-LA kanye nengozi yakho siqu yokuthuthukisa ama-blood clots. Udokotela wakho angase abe nezincomo, eziqondene nawe, ezingasiza ukunciphisa ingozi yakho.

Imithombo:

Antiphospholipid Antibodies. Isikhungo se-Johns Hopkins Lupus.

I-Lupus Anticoagulants ne-Antiphospholipid Antibodies. I-MedlinePlus. Ilabhulali Kazwelonke Yezokwelapha yase-US. NgoJanuwari 20, 2015.

Antiphospholipid Antibodies. Lupus Foundation of America. Agasti 2008.