I-Lumbrokinase iyi-enzyme etholakala kuLumbricus rubellus, uhlobo lwezilwane zomhlaba. Kuthengiswa ngefomu lokuxhaswa kokudla, libizwa ngokuthi i-enzyme ye-fibrinolytic (into ekhuthaza ukuwohloka kwe-fibrinogen, iphrotheni ehilelekile ekwakhiweni kwezindwangu zegazi). Ukucatshangelwa nge-lumbrokinase kucatshangwa ukuthi kunikeze izinzuzo eziningana zezempilo, kuhlanganise nokuthuthukisa impilo yenhliziyo nokusiza ekuvimbeleni isifo ngokulwa namagundane egazi.
Ukusetshenziswa
Abagqugquzeli basikisela ukuthi i-lumbrokinase ingasiza ngezimo zezempilo ezilandelayo:
Izinzuzo
Kuze kube manje, ucwaningo ngemiphumela yezempilo lumbrokinase lukhawulelwe. Noma kunjalo, kunobunye ubufakazi bokuthi kubonisa isithembiso sokuphathwa kwezimo ezithile. Nakhu ukubheka okutholakala eziningana ngezinzuzo ezikhona:
1) Impilo Yenhliziyo
I-Lumbrokinase ingasiza ekwelapheni i-angina, ngokusho kwesifundo sokuqala esanyatheliswa kuyi- Journal of Alternative and Complementary Medicine ngonyaka ka-2009. Ukuze kuhlolwe, abacwaningi babela abantu abangu-10 abanezifo zenhliziyo futhi angina inyanga eyodwa yokwelapha nge-lumbrokinase (ngaphezu kwalokho ekunakekeleni kwabo okujwayelekile). Ngokuphela kwesifundo, izibonakaliso ze-angina zathuthukile kwiziguli eziyisithupha.
Ngaphezu kwalokho, isifundo sokuqala esashicilelwe emaphephandabeni aseChina u- Acta Pharmaceutica Sinica ngo-2006 sathola ukuthi i-lumbrokinase ingavikela impilo yenhliziyo.
Ekuhlolweni kwamagundane, abalobi bezocwaningo banqume ukuthi i-lumbrokinase ingavikela ngokumelene ne-myocardial ischemia (isimo esibonakala ngokuvinjelwa kwamathambo e-coronary nokunciphisa ukugeleza kwegazi enhliziyweni).
2) Ukushaya isisu
Ucwaningo lokuqala lubonisa ukuthi i-lumbrokinase ingasiza ekuqedeni isifo sohlangothi. Esifundweni sika-2013 eshicilelwe kuyi- Chinese Medical Journal , isibonelo, abantu abangu-310 esibhedlela ngesifo so-ischemic (uhlobo lohlangothi olwenzeka lapho umthambo ebuchosheni buvinjelwe) baphathwa ngezokwelapha okujwayelekile noma ukwelashwa okuvamile kanye namaphilisi amancane lumbrokinase owodwa ngonyaka.
Ngokuphela kwesifundo, iqembu elithola ukwelashwa kwe-lumbrokinase lalinemivimbo embalwa ye-ischemic.
Esifundweni sika-2008 esivela kuyi- European Journal of Pharmacology , ukuvivinywa kwamangqamuzana omuntu kunqume ukuthi i-lumbrokinase ingasiza ekuqapheni ukulwa nesifo se-cerebral ischemia. (Isimo esibonakaliswe ukungena kwegazi okwanele ebuchosheni, i-cerebral ischemia inganciphisa ukuhlinzeka kwe-oxygen engqondweni, futhi iholele ekushayweni.) Ucwaningo lubuthole ukuthi i-lumbrokinase ingase ibhekane ne-cerebral ischemia ingxenye ngokuvimbela ukwakheka kwegazi.
Ngaphezu kwalokho, isifundo esincane esanyatheliswa ku- Clinical Hemorheology and Microcirculation ngo-2000 sathola ukuthi i-lumbrokinase ingaba nenzuzo ekwelapheni kwe-cerebral infarction (uhlobo lwesifo so-ischemic esibangelwa ukwakhiwa kwe-clot yegazi ngaphakathi kwengqondo).
Ukuze kuhlolwe, abantu abangu-31 abane-cerebral infarction baphathwa nge-lumbrokinase, kanti ezinye iziguli ezingu-20 zanikezwa eqenjini lokulawula. Imiphumela yabonisa ukuthi i-lumbrokinase ingasiza ukuphatha i-cerebral infarction ngokwengxenye ngokunciphisa i-fibrinogen.
3) Isifo sikashukela
Isifundo esekelwe ngesilwane eshicilelwe ku- Diabetes Research and Clinical Practice ngo-2013 sikhombisa ukuthi i-lumbrokinase ingasiza ekulwa nesifo sofuba sesifo sikashukela (isimo sezinso esibangelwa yingxenye yokulawulwa kabi kwesifo sikashukela nokucindezelwa kwegazi ).
Ekuhlolweni okubandakanya amagundane ayisifo sikashukela, ososayensi baphawula ukuthi ukwelashwa nge-lumbrokinase kwasiza ekuvikeleni isifo sofuba se-diabetes (mhlawumbe ngokuthinta ama-enzyme athile acatshangwa ukuthi ayingxenye yokulimala kwezinso ezihlobene nalesi simo).
Imiphumela Ezingenakwenzeka
Njengoba izifundo ezimbalwa kangaka ziye zahlola imiphumela ye-lumbrokinase kubantu, kusheshe ukutshela ukuthi i-lumbrokinase iphephile yini isikhathi eside noma ukusetshenziswa njalo. Abesifazane abakhulelweyo, omama abahlengikazi, nezingane akufanele bathathe i-lumbrokinase.
Kukhona nokukhathazeka okunye ukuthi i-lumbrokinase ingabangela imiphumela eminye yemiphumela emibi, kufaka phakathi isicanucanu, ukubhubhisa, isifo sohudo, ukuqhuma kwesikhumba, nokuphendula okwenziwe.
Njengoba kuthiwa i-lumbrokinase idiliza i-fibrinogen (okudingekayo ukwakha ama-blood clots), kungokwemvelo ukuthi kungenzeka ukuthi ukuphazamiseka kungaphazamisa inqubo yokuvala i-clotting evamile futhi kuholele ekukhenikeni.
Abantu abanezimo ezihambisana nenengozi yokwanda kwegazi akufanele bathathe i-lumbrokinase. Akufanele kuthathwe ngaphambi kokuhlinzwa noma okulandelayo. Akufanele futhi kuthathwe ngemithi, izithako zokudla, noma amakhambi anomthelela omuhle wegazi.
Kubalulekile ukukhumbula ukuthi ama-supplements awazange ahlolwe ukuphepha kanye nezondlo zokudla ngokuvamile azihambisani nomthetho. Nazi amathiphu amaningi okusebenzisa izithako zokudla ngokuphepha.
Okubalulekile
Ngenkathi ucwaningo lokuqala luyinkimbinkimbi, kunesidingo esikhulu sokuhlolwa kwemitholampilo-uhlobo locwaningo ofuna ukubona ukubeka isisetshenziswa esigcwele ukwelashwa-okuqinisekisa le miphumela. Uma usacabanga ukuthi uyayisebenzisa, kubalulekile ukuthi uthintane nodokotela wakho ukuze axoxe ukuthi kulungile yini futhi uphephile kuwe futhi ulinganise izinzuzo nezingozi. I-Lumbrokinase akufanele isetshenziswe esikhundleni sokwelashwa okujwayelekile ngezimo ezifana ne-angina noma isifo sohlangothi.
Ukuze uthole usizo ekunciphiseni ingozi yakho yokushaya isifo, kubalulekile ukulawula ukucindezeleka kwegazi ne-cholesterol, landela ukudla okulinganiselayo, ukuzivocavoca njalo, futhi ugweme ukubhema. Ucwaningo oluthile lubonisa ukuthi abantu abadla itiye eluhlaza, itiye elimnyama, nama-fatty acids ama-omega-3 bangase babe nomngcipheko wokunciphisa.
Imithombo:
> Cao YJ, Zhang X, Wang WH, et al. I-lumbrokinase ye-oral fibrinogen-depleting agent yokuvimbela isifo sokulimaza: imiphumela evela ekulinganisweni komtholampilo ehlukahlukene, engahleliwe, ehambisana neqembu futhi elawulwayo. I-Chin Med J (Engl). 2013 Nov; 126 (21): 4060-5.
> Ji H, Wang L, Bi H, et al. Izindlela ze-lumbrokinase ekuvikeleni i-cerebral ischemia. I-Eur J Pharmacol. 2008 Aug 20; 590 (1-3): 281-9.
Jin L, Jin H, Zhang G, Xu G. Izinguquko ku-activator and tiscues plasminogen activator emva kokwelashwa kwe-cerebral infarction ne-lumbrokinase. I-Clin Hemorheol Microcirc. 2000; 23 (2-4): 213-8.
Kasim M, Kiat AA, Rohman MS, Hanifah Y, Kiat H. Ukuthuthukiswa kwe-myocardial perfusion ku-angina pectoris esinezinzile nge-lumbrokinase yomlomo: isifundo somqhubi. J Altern Supplement Med. 2009 Meyi; 15 (5): 539-44.
I-Sun H, i-Ge N, i-Shao M, i-Cheng X, i-Li Y, i-S, i-Shen J. Lumbrokinase igxila ukungena kwesifo sikashukela ngokulawula ukuchithwa kwe-matrix e-stellaptozotocin. Isifo sikashukela se-Clinic Pract. 2013 Mar; 100 (1): 85-95.
Ukuziphendulela: Ulwazi oluqukethwe kule sayithi luhloswe ngezinjongo zemfundo kuphela futhi aluthathi iseluleko, ukuxilongwa noma ukwelashwa ngudokotela olayisensi. Akuhloselwe ukumboza zonke izinyathelo zokuqapha, ukusebenzisana kwezidakamizwa, izimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.