I-Nodular sclerosing Hodgkin lymphoma, umdlavuza wamangqamuzana angama-lymph, uhlobo lwesifo se-Hodgkin. Uhlobo oluvame kakhulu lwe-Hodgkin lymphoma emazweni athuthukile, okubalwa ngamaphesenti angama-60 kuya kwangu-80 kubo bonke abantu abathintekayo lesi sifo.
I-Nodular sclerosing i-Hodgkin lymphoma ithinta kakhulu intsha kanye nabantu abadala. Kubuye kuvame kakhulu emantombazaneni kunabesilisa.
Igama elithi 'nodular sclerosing' lisuselwa ekubukeni kwamathambo e- lymph node ngaphansi kwe-microscope kulolu hlobo lwe-Hodgkin lymphoma.
Izimpawu ezisemqoka ze-nodular sclerosing i-Hodgkin lymphoma zikhuliswa ngamagciwane lymph entanyeni, izibopho noma ngaphakathi kwesifuba . Ukuxilongwa kwe-lymphoma kwenziwa nge-lymph node biopsy.
Iningi labantu litholakala ezinyathelweni zakuqala futhi lingelashwa ngemithi ehlanganisa ukwelashwa kwe-chemotherapy kanye nokwelashwa kwemisebe.
Omunye Wama-Hodgkin Lymphomas ahlukahlukene
Amagama azo zonke izinhlobo ze-lymphoma nama-subtypes ayadideka ngisho nodokotela abangabhekane nabo njalo. Isifo se-Hodgkin ne-Hodgkin lymphoma sisho into efanayo, noma kunjalo, kunezinhlobo eziningi ezahlukene ze-lymphoma, okuthi i-Hodgkin iyingxenye eyodwa. Futhi kunezinhlobo eziningana ezehlukene zeHodgkin lymphoma, futhi. Ngakho-ke, nansi ukuhlaselwa kwe-nodular sclerosing i-Hodgkin lymphoma lapho ihlangana khona nesithombe esikhulu kunazo zonke ze-lymphomas:
Izigaba ezimbili eziyisisekelo ze-lymphoma yi- Hodgkin ne-Non-Hodgkin lymphoma.
I-Hodgkin lymphoma ingase iqhubekele phambili ibe ngamaqembu amabili:
- I-Classic Hodgkin lymphoma - enama-subtypes amaningana
- I-lodphocyte engavamile ye-Hodgkin lymphoma
"I-lymphocyte engavamile" ne "nodular sclerosing" ayiyona into efanayo - ibhekisela ezinhlobonhlobo ezimbili zeHodgkin lymphoma.
I-Nodular Sclerosing Hodgkin lymphoma - i-lymphoma echazwa manje - iyinhlangano ye-Classic Hodgkin lymphoma. I-Classic Hodgkin lymphoma inama-subtypes amane alandelayo:
- I-sclerosing ye-Nodular
- I-cellularity ehlanganisiwe
- I-Lymphocyte-ecebile
- I-lymphocyte-iphelile.
Izibuyekezo: I-Nodular Sclerosing Classic Hodgkin Lymphoma
I-Nodular sclerosis I-Hodgkin lymphoma (i-NSHL) yiyona ndlela ejwayelekile kunazo zonke ezithinta izifo zamathambo phakathi kwabantu abasha kanye nabantu abadala abasezikhungweni ezimboni. I-NSHL nayo inezinto ezinamandla ezizuzwa njengefa, inengozi eyi-100 ekhuphuke ngamawele afanayo.
Muva nje, kwakukhona isifundo esikhulu esenziwe ngokubambisana kwemisebe ye-ultraviolet kusukela elangeni kanye ne-subtypes ehlukene ye-Hodgkin lymphoma. Esifundweni sika-Emily Bowen kanye nosebenza nabo, izimo zeHodgkin lymphoma zaziphansi kunazo zonke emaqenjini abantu abanokukhanya kwelanga eliphakeme kunazo zonke. Nakuba lokhu kutholwa kwakuyisimo, kodwa kuphela, lo mkhuba wabonakala unamathela kubantu abane-nodular sclerosis subtype.
Ezinye izifundo zamuva zihlolisise ukwelapha okuthile, ukuvimbela ukuzivikela kwamagciwane, nokuthi zingase zihlanganyele kanjani nezinqubo ezahlukene ezaziwa ukuthi ziqhubeka ngezinhlobo ezithile ze-HL zakudala.
Ucwaningo olwenziwa nguPeter Hollander kanye nosebenza nabo lwaphawula ukuthi ukuvimbela ukuzivikela kwamagciwane okubhekiswe ekutheni i-receptor ye-death receptor (PD) -1 iyindlela entsha yokwelashwa ekubuyiseleni futhi okuphikisanayo kweHodgkin lymphoma.
Leli qembu lithole ukuthi izici ezithile zamangqamuzana atholakala kuzo zonke izidumbu, futhi hhayi zezingqimba zomzimba ngokwazo, zaxhunyaniswa nokubikezelwa. Ucwaningo lubuthole ukuthi imiphumela ye-HL yakudala yayibi nakakhulu uma la maseli egazi amhlophe azungezile, noma amangqamuzana e-microenvironment, ayenamazinga amakhulu enza i-PD-1 ne-PD-L1. Bahlongozela ukuthi lezi zingxenye ezincane zeziguli zingase zizuze emiphakathini ekhukhumezayo ye-chemotherapy futhi, mhlawumbe, kusukela ku-PD-1 inhibitors njengokwelashwa kwangaphambili.
> Imithombo:
> Cozen W, Li D, Best T, et al. Ukuhlaziywa kwe-genome-wide wide of nodular sclerosing Hodgkin lymphoma kubonisa ingozi loci ngo-6p21.32. Igazi. 2012; 119 (2): 469-475.
> Hollander P, Kamper P, Ekstrom K, et al. Ukulinganisa okuphezulu kwe-PD-1 + ne-PD-L1 + leukocyte ku-classical Hodgkin lymphoma microenvironment kuhlobene nomphumela ongaphansi. I-Blood Adv. 2017; 1 (18): 1427-1439.
> Bowen EM, Pfeiffer RM, Linet MS, et al. Ubudlelwane phakathi kwemisebe emincane ye-ultraviolet ne-Hodgkin lymphoma subtypes e-United States. I-British Journal of Cancer. 2016; 114 (7): 826-831.