I-SPS ibangela ukunyakaza kwama-Muscle kanye nama-Spasms
I-stiff person syndrome (ebizwa nangokuthi i-Moersch-Woltmann syndrome) noma i-SPS yinkinga yesifo sezinzwa ezingavamile lapho ukuqina kobuhlungu be-muscle kufika khona futhi kuya khona. Ukucwaninga kusikisela ukuthi isifo somuntu oqinile nesifo esizimele, futhi abantu abane-syndrome bavame ukubhekana nokuphazamiseka okuzenzakalelayo okunjenge- type 1 yesifo sikashukela noma i- thyroiditis .
Isifo somuntu oshubile sithinta kokubili abesilisa nabesifazane futhi singaqala nganoma isiphi isikhathi, nakuba ukuxilongwa ngesikhathi sezingane kungavamile.
Ayaziwa ukuthi bangaki abantu abahlupheka ngakho.
Izimpawu ze-Stiff Person Syndrome
Izimpawu zesifo somuntu onzima zingabandakanya:
- Ukuqina kobunzima emgodini nasemigqeni ezayo futhi iyahamba-lokhu kubangela ukuqina komzimba noma ubuhlungu, ukunyakaza okuqondile okugqamile, nokuhamba okunamandla
- Imisipha emisipha emilenzeni nasemilenzeni lapho umuntu ehlaselwa, ethinteka, ecasulayo, noma ecindezelekile
- I-backback ephansi engezansi (lordosis) namajoyina aphikisayo emzimbeni, ngokuhamba kwesikhathi
- Ukuwa ngesikhathi sokuphazamiseka kwemisipha (kungabangela izinkinga ezengeziwe ezihlobene)
Ukuxilongwa kwe-Stiff Person Syndrome
Izimpawu zikhomba ukuthi ukuxilongwa. Kodwa-ke, ngoba kuyisifo esingavamile, kungase kungabhekwa njenge- Parkinson isifo , i- multiple sclerosis , i- fibromyalgia , noma isifo sengqondo.
Ukuxilongwa ngezinye izikhathi kungaqinisekiswa ngokuba khona kwama-anti-GAD antibodies, noma ezinye izinhlobo zama-antibodies uma i-syndrome ihlotshaniswa namanye khansa.
Kodwa-ke, amaphesenti angu-35 weziguli ezinesifo somuntu onzima asinayo i-antibodies futhi ayikho i-cancer ehambisanayo.
Okunye ukuhlolwa kungenziwa, njenge-hemoglobin A1C ukuhlola isifo sikashukela noma i-hormone ye-thyroid-stimulating (TSH) ukuze uhlole i-thyroiditis. Ukuhlolwa kwe-muscle (i-electromyography noma i-EMG) kungenziwa futhi.
Ukwelashwa kwe-Stiff Person Syndrome
Nakuba kungekho ukwelashwa kwesifo somuntu onzima, kunezindlela zokwelashwa ezitholakalayo. Izidakamizwa ezifana ne-azathioprin (i-Azasan), i-diazepam (iValium), i-gabapentin (i-Neurontin), i-tiagabine (i-Gabitril), noma i-baclofen (i-Lioresal) ingasetshenziswa. Izimpawu kulabo abane-khansa ezihambisanayo zingathuthuka ngemuva kokuba isisu sisusiwe futhi kunikezwa ukwelashwa kwe-steroid. Ukushintshaniswa kwe-plasma (plasmapheresis) kusiza ukunciphisa izimpawu kwabanye abantu, kodwa lokhu kukwelashwa kuvame ukugcinwa kulabo abasengozini yokuphefumula ukuphefumula. Kwabanye, i-immunoglobulin ene-intravenous (IVIg) iyasiza. Ukwelashwa ngokwemvelo kungasiza ukukhulula izimpawu ezihlobene nokucindezeleka komzimba okwesikhashana, kodwa kungase futhi kubangele ukuphazamiseka kwemisipha. I-Corticosteroids ingasiza futhi, nakuba kufanele inikwe ngokucophelela labo abanesifo sikashukela.
Imithombo:
"Ikhasi Lolwazi Lwabantu Abathintekayo Bama-NINDS." Izinkinga. 14 Feb 2007. Isikhungo seNational of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/stiffperson/stiffperson.htm.
U-Rodgers-Neame, uNancy. "I-Stiff Person Syndrome." eMedicine. 20 Mashi 2006. WebMD. http://www.emedicine.com/neuro/topic353.htm.
I-autoantibodies ku-protein yamaphilisi angu-128-kd kubesifazane abathathu abane-syndrome yesifo esinzima nesifo somdlavuza wesifuba. I-AU Folli F; Solimena M; Cofiell R; I-Austoni M; Tallini G; Fassetta G; Ama-Bates D; I-Cartlidge N; I-Bottazzo GF; I-Piccolo G; et al. SO N Engl J Med 1993 Feb 25; 328 (8): 546-51
I-Heterogeneity ye-autoantibodies e-stiff-man syndrome. I-AU Grimaldi LM; I-Martino G; Braghi S; I-Quattrini A; I-Furlan R; UBosi E; I-Comi GSO Ann Neurol 1993 Jul; 34 (1): 57-64.
I-steroid-esabelayo futhi isondelene-isifo-man syndrome: isifundo somtholampilo kanye ne-electrophysiological yamacala amabili. I-AU i-Piccolo G; Cosi V; I-Zandrini C; Moglia ASO Ital J Neurol Sci 1988 Dec; 9 (6): 559-66.