Ukuhlolwa Kwegazi Kuhlola Izifo Umsebenzi We-Arthritis Ye-Rheumatoid
Kunezivivinyo ezimbalwa zegazi odokotela ngokuvamile abahlela ukuhlola ukuvuvukala nokusiza ukuxilonga i-arthritis. Ukuhlolwa kwegazi okuvamile okwenziwe ngeziguli ezisolakala ukuthi kunesifo samathambo , noma ukuqapha ukusebenza kahle kokwelapha, kufaka izinga le- erythrocyte lokuguqula amanzi , i- CRP , i- rheumatoid factor , ne- anti-CCP . Kodwa, kukhona ingane "entsha" ebhodini, okukhulumisana, okubizwa nge-Vectra DA.
I-Vectra DA, eyakhiwe yiCrescendo Bioscience, isifo segazi se-multi-biomarker sokuhlola isifo sofuba se-rheumatoid arthritis kulezi ziguli eziphathwe nge- DMARD (izidakamizwa eziguqula izidakamizwa eziphikisayo) nezidakamizwa ze-biologic . I-DA ye-Vectra ihlanganisa iphaneli lama-proteine angu-12 asemqoka ahlotshaniswa nesifo samathambo e-rhythmic test into eyodwa yokuhlola eyenza inhloso, amaphuzu amaningi okuhambisana nomsebenzi wesifo. Isibalo, 0-100 (amaphuzu aphansi abonisa umsebenzi omncane wesifo), kusiza odokotela neziguli ukwenza izinqumo zokwelashwa njengoba beqhubeka phambili.
I-Vectra DA yaqala ukuqala ngasekupheleni kuka-2010. Kusukela ngaleso sikhathi, ngokusho kweCrescendo Bioscience, izazi ze-rheumatologists ziye zasebenzisa ulwazi ukuthi ithuluzi linganikeza ukuhlola umsebenzi wesifo kubantu abane-arthritis ye-rheumatoid. I-Vectra DA iyatholakala kuwo wonke ama-50, futhi ukuhlolwa kwenziwa ku-Crescendo Bioscience's Clinical Laboratory Improvement Amendments (CLIA).
Ngemuva kokuthi isampuli yegazi itholwe futhi ihlolwe, imiphumela ibikwa phakathi kwezinsuku ezingu-7 ukuya kwezingu-10. Odokotela bangathola imiphumela ngezindlela ezimbalwa ezahlukene: iposi leposi, ifeksi, noma ku-portal yewebhu ye-Vectra View.
Hlola ne-insurer yakho yangasese ukuqinisekisa ukuthi i-Vectra DA ihlanganiswe umshwalense wakho. I-Medicare ihlanganisa i-Vectra DA ngokugcwele ngaphandle kokukhokhwa noma ukukhishwa.
I-Crescendo Bioscience ifuna ukuqinisekisa ukuthi izindleko akukaze kube yisithiyo kunoma ubani one-arthritis ye-rheumatoid okufanele abe nokuhlolwa. Ungabiza u-1-877-RHEUMDX (1-877-743-8639) ukuze ufunde ngosizo lwezezimali.
Ama-Biomarkers angu-12 e-Vectra DA
I- biomarker iyi-molecule emzimbeni ongahlolwa ngokulinganayo futhi ahlolwe. Isetshenziselwa ukunquma umsebenzi ojwayelekile noma umsebenzi wesifo ongavamile, noma ukusebenza kokwelashwa.
I-VCAM-1 (i-molecular cell adhesion molecule-1) idlala indima ekusebenzisaneni phakathi kwamaseli, imithambo yegazi kanye nezicubu ezixhunyiwe kuhlangene. Ezingxenyeni ezithintekayo yi-rheumatoid arthritis, ukuxhumana kungasiza ekwakhiweni kwamaseli avuthayo.
I-EGF (i-epidermal growth factor) ikhiqizwa ngamangqamuzana ezicubu ezihlangene ezithinteka yi-rheumatoid arthritis, ukukhuthaza ukukhula kwamangqamuzana nokuvuvukala.
I-VEGF-A (i-vascular endothelial growth factor A) ikhiqizwa ngamalungu avulekayo, okufaka isandla ekwakheni izitsha zegazi, ekwakhiweni kwegazi kanye nokukhukhula kwamathambo.
I-IL-6 (interleukin 6) iqhuba ukuvuvukala, ukuwohloka kwe-cartilage, nokuguguquka kwamathambo okuhlobene nesifo samathambo.
I-TNF-RI (i-tumor necrosis factor receptor, uhlobo lo-1) yi-receptor ye-TNF-alpha, enye i-molecule eqhuba ukuvuvukala okuhlangene nokubhujiswa.
I-MMP-1 (i-matrix metalloproteinase-1 noma i-collagenase-1) i-enzyme eyenza ukubhujiswa kwe-cartilage ku-rheumatoid arthritis.
I-MMP-3 (i-matrix metalloproteinase-3 noma i-stromelysin-1) iyi-enzyme ebulala izingxenye ze-cartilage.
I-YKL-40 iyiprotheni esiza ukulawula ukulungiswa kwezicubu nokubhujiswa.
I-Leptin iyi-hormone efihliwe yizicubu ezinamafutha, amangqamuzana amathisamu ahlangene, namathambo. I-Leptin inegalelo ekuvuvukala futhi ilawula ukulungiswa kwamathambo.
I-Resistin iyi-hormone eyimfihlo ngamangqamuzana ezicubu ezihlangene nethambo elifaka isandla ekuvuvukala nokulawula ukulungiswa kwethambo.
I-SAA (i-serum amyloid) yiprotheni eyenziwa yisibindi ngokuphendula ukuvuvukala.
I-serum amyloid ingase ikhiqizwe yizicubu ezihlangene futhi, lapho ingenza khona amasosha namasosha omzimba.
I-CRP (i-pro-protein esebenzayo) ikhiqizwa yisibindi ngokuphendula ukuvuvukala.
Okushiwo I-Score Yakho
Ukuchaza isikolo sakho kubalulekile: 45 kuya ku-100 kubonisa izinga eliphezulu lomsebenzi wesifo; 30 kuya ku-44 kubonisa umsebenzi wesifo esifanele; futhi u-1 kuya ku-29 ubonisa izinga eliphansi lomsebenzi wesifo.
Okubalulekile
Isivivinyo se-Vectra DA sifanele iziguli ezitholakale zitholwe ukuthi zine-arthritis ye-rheumatoid, ecela isicelo sikadokotela, ekhetha ukuba nesilinganiso sabo somsebenzi wesifo sihlolwe. Ayisetshenziselwa ukuxilonga i-arthritis. Ihlola umsebenzi wesifo.
Ngo-2016 EULAR (European League Against Rheumatism) umhlangano waminyaka yonke, imiphumela yocwaningo yanikezwa, ngaphezu kokulandela umsebenzi wesifo, i-Vectra DA ingase "ibikezele ukuqhuma nokulondolozwa okuqhubekayo ezigulini ezishiya ukwelashwa, kanye nokuphendula ukwelashwa kwi-biologic kanye non -therapies zokwelashwa. "
> Imithombo:
> I-Vectra DA. Ukuhlolwa Komsebenzi Wezifo.
> I-Crescendo Bioscience Yenza ukuthi iNew Data ku-Vectra DA Izobekwa E-European League Against Rheumatism 17th Annual Congress. I-Crescendo Bioscience. Juni 10, 2016.