Ukubuza Ukuthi Utshwala Kakhulu Kangakanani
Kuyavuma kahle ukuthi umuntu one- hepatitis C engapheli kanye nomlando wokusetshenziswa kabi kotshwala utshwala kunethuba elikhulayo lokuthuthukisa isifo sesibindi esiphezulu, kuhlanganise ne- cirrhosis ne- hepatocellular carcinoma (uhlobo lwesifo somdlavuza wesibindi). Zombili lezi zimo zisebenza ndawonye ukuze zithuthukise ngokuphumelelayo ukuthuthukiswa, ukuqhubeka nokuqina kwesifo sebindi .
Ngokwakhe, ukungenisa utshwala obunzima kungabangela uhlobo lwe-hepatitis engenayo igciwane ebizwa ngokuthi i-hepatitis yotshwala. Uma ubhanjiswe ne-hepatitis ye-viral (ngesimo se- hepatitis B noma i-hepatitis C), umthelela esibindi ungakhuphuka ngokweqile.
I-Hepatitis C nayo itholakale kimi evamile kubantu abanomlando wokusebenzisa kabi utshwala kunabangewona abaphuza. Ngenkathi izizathu zalokhu zingekho ngokucacile, siyazi izinto ezimbili:
- Ukuthi utshwala nokusetshenziswa kwezidakamizwa ezijova kakhulu kuxhumene, futhi;
- Ukusetshenziswa kokusetshenziswa kwezidakamizwa okuqhubekayo kuyisimo esiyinhloko sokudluliselwa kwe-hepatitis C e-US
Lezi zinhlangano ziqokomisa isidingo sokubhekana nokudla utshwala kubo bonke abantu abane-hepatitis C engapheli, kungaba uphawu noma cha; futhi ukubhekana nokusetshenziswa kotshwala noma nini lapho uqala isu lokuvimbela i-HCV, ikakhulukazi phakathi kwabajova abasebenzisa izidakamizwa kanye namanye amaqembu aphezulu.
Phakathi kwezingozi ezihlobene nokusetshenziswa kotshwala no-hepatitis C:
Ingozi Ekhulayo Ye-Cirrhosis
Akungabazeki ukuthi abantu abane-hepatitis C abangasapheli abaphuza utshwala banethuba elihle lokuthuthukisa i- cirrhosis . Kusukela ku-epidemiological point of view, abangaphezu kuka-90% abaphuza utshwala (okuchazwe njengabesifazane abaphethe iziphuzo ezimbili ngosuku kanye nabesilisa abaneziphuzo ezintathu ngosuku) bazokhula nezifo zesibindi ezinamafutha , okungaba ngu-20% kuzokhula isibindi sesibindi phakathi kweminyaka engu-10-20.
Ukutheleleka kwe-Hepatitis C kuqhuba inkambo efanayo, kanti abantu abangama-75% abanesandulela ngculaza bahlakulela isifo esingelapheki, kuyilapho u-15-20% uzoqhubeka nezifo eziphambili eminyakeni engama-10-30.
Ukuhlanganiswa kwalezi zici ezimbili kuhamba ngesivinini nje kuphela, futhi kwandisa ukulimala kwesibindi-ngokulinganiselwa okunye, okungaba ngu-200-300%. Ngaphezu kwalokho, abasebenzisi bokuphuza utshwala abane-HCV banengozi engaba ngu-11 enkulu yokuthuthukisa i-cirrhosis kunabangewona abaphuza nge-HCV.
Ukwandisa Ingozi Ye-Hepatocellular Carcinoma
I-hepatocellular carcinoma (HCC) iyindlela ejwayelekile kakhulu yomdlavuza wesibindi e-US futhi enye yezinkinga ezivame kakhulu zokutheleleka okungapheli kwesifo se-hepatitis C. Ngaphezulu kakhulu kune-cirrhosis yesibindi, inhlangano ephakathi kokudakwa ngokweqile ne-HCC inamandla, kanti amacala angu-80% we-HCC abhekwa njengabasebenzisi bokuphuza utshwala.
Ingozi ibonakala iyanda ngenani umuntu aphuzayo. Ucwaningo olulodwa lwase-Italy lubonise ukuthi amathuba e-HCC aphinde kabili lapho umuntu ephuza phakathi kweziphuzo ezingu-3.4 no-6.7 ngosuku. Ngokufanayo, ucwaningo luye lwabonisa ukuthi ukuphuza ngokweqile kungasheshisa ukuthuthukiswa kwe-HCC ngeminyaka emihlanu, okubangelwa izicubu ezingaphezu nje kuphela kodwa izikhathi ezincane zokusinda.
Ukunciphisa Ukuphumelela Kwezokwelapha ezisekelwe ku-Peginterferon
Nakuba i- peginterferon yezidakamizwa isetshenziselwa kakhulu ukwelashwa kwe-HCV yesimanje, isavamile lapho kwenzeka khona ukwelashwa ngaphambilini kanye / noma ukuxilongwa kwesifo esibindile sesibindi.
Kuyaphawuleka ukuthi ngokuvamile kuvame ukuba neziguli ezinomlando wokusebenzisa kabi utshwala ezidinga i-peginterferon-based based
Utshwala luphazamisa ukuphumelela kwe-peginterferon, okubangelwa ingozi engama-300% yokuguqulwa kwamagciwane (okungukuthi, ukubuya kwegciwane) ngemuva kokuqeda ukwelashwa. Ngokumangazayo, ingozi yokuhluleka yabonakala ifana phakathi kokubili abaphuzi abaphuza nabaphuza kakhulu uma kuqhathaniswa nabangewona abaphuza nge-HCV.
Utshwala Kakhulu Kangakanani?
Kuze kube manje akucaci ukuthi isikhathi eside isiguli kufanele siphuze utshwala ngaphambi kokuba imiphumela emibi yokuphuza utshwala iguqulwe. Kungenxa yalesi sizathu ukuyeka ukuphuza utshwala (kanye nohlelo lokuphuza utshwala, uma kudingekile) kuhlolwe njengengxenye yocwaningo lokwelashwa kubantu abane-HCV yokutheleleka okungapheli, ikakhulukazi labo abatholwa ukuthi bane- cirrhosis ekhokhelwa noma ekhokhelwayo .
Ngaphezu kwalokho, iziguli ezidinga i-peginterferon zinconywa ukuba ziyeke okungenani izinyanga eziyisithupha ngaphambi kokuqala ukwelashwa futhi kufanele zitshelwe ukuba ziqhubeke nokuqhubeka nokuphuza utshwala okungenani izinyanga eziyisithupha ngemuva kokuphothula ukwelashwa.
Imithombo:
UMeller, uS .; I-Millonig, i-G .; futhi u-Seitz, H. "Isifo sesibindi sokuphuza utshwala, nesifo sofuba esibhekene ne-hepatitis C: Inhlanganisela evame ukuphikiswa." I-World Journal ye-Gastroenterology. NgoJulayi 28, 2009; 15 (28): 3462-3471.
Izikhungo Zempilo Zikazwelonke (NIH). "I-Hepatitis C ne-Alcohol." I-Bethesda, e-Maryland; eshicilelwe ngo-Septhemba 29, 2004.