Amanye ama-Inhibitors e-Proton Pump atholakala ngaphezu kwe-Counter
Imishanguzo evamile kakhulu yemithi esetshenziselwa ukwelashwa kwezifo ze-Reflux Gastroesophageal (GERD) yi- proton pump inhibitors (i-PPIs).
I-proton pump inhibitors yi-reducers ye-asidi. Odokotela bamisela ama-PPIs ukuphatha abantu abanezimo eziningana ezifaka:
- Ukuguquka kwesisu (isifo se-reflux se-gastroesophageal)
- Izilonda zesisu noma amathumbu
- Ukwelashwa kwe- Helicobacter pylori
- Isisu esiswini esiningi ( iZollinger-Ellison Syndrome )
Indlela ama-PPIs asebenza ngayo
Esinye sezizathu zokuthi kungani ama-proton pump inhibitors enqunywe njalo ngenxa yokuthi athambekele ekunciphiseni ukukhwabanisa ngempumelelo.
Isisu sakho sikhiqiza i-asidi ukusiza ukudiliza ukudla ngakho kulula ukugaya. Ezimweni ezithile, le-asidi ingamcasula isilonda esiswini sakho kanye ne-duodenum (igama lezokwelapha engxenyeni engenhla yamathumbu akho amancane) okubangelwa ukugubha kanye nezilonda.
Isisu sinompheme, okuthiwa i-gastric acid pump, eveza isisu esiswini. Ama-PPI avimbela ukufihla kwe-asidi esiswini ngokubopha kulezi zimpompi. Ukunciphisa inani lesisu esiswini kungasiza izilonda ziphulukise futhi zifake i-reflux.
Imithi ekhona ye-PPI
Nakhu ama-PPI ayisikhombisa atholakalayo, amanye angaphezu kwe-counter futhi amanye ngokudayiswa kuphela:
- I-Aciphex (i-Rabeprazole)
- I-Nexium (Esomeprazole)
- I-Prevacid (i-Lansoprazole) -yatholakala ku-over-the-counter
- I-Prilosec (i-Omeprazole) -yatholakala kule-counter-counter
- I-Protonix (i-Pantoprazole)
- I-Dexilant (Dexlansoprazole)
- I-Zegrid (i-omeprazole / i-sodium bicarbonate) -yatholakala kule-counter-counter
Ama-PPI Ku-GERD ethathwe
Uma udokotela wakho ancoma i-PPI ekuphatheni i-GERD, kungenzeka ukuthi uye wakhuthaza izinguquko zokuphila ezifana nokulahlekelwa isisindo (uma kunesisindo noma ukugqwala), ukuphakamisa ikhanda lombhede wakho ebusuku, futhi ungadli amahora amabili kuya kwamathathu ngaphambi kokulala.
I-PPI ivame ukuthathwa kanye nemizuzu engama-30 kuya kwengu-60 ngaphambi kokudla kwasekuseni, futhi ithathwa cishe amasonto ayisishiyagalombili, lapho udokotela wakho azohlola khona ukuthi uzizwa kanjani. Uma uphuthukisiwe, udokotela wakho anganciphisa umthamo wakho noma ayeke ngisho nemithi yakho. Ngempendulo eyingxenye, udokotela wakho angakwandisa umthamo wakho kabili ngosuku. Uma ungakatholi impumuzo ku-GERD yakho, udokotela wakho cishe uzokutshela ochwepheshe (i-gastroenterologist) noma aphinde ahlolisise ukuxilongwa.
Ukwelashwa kwe-PPI akusho ukuthi kuthathwe isikhathi eside, ngakho-ke umgomo ukuwuthatha umthamo ophansi kunazo zonke ongasenza ngcono ukushaya kwenhliziyo nokuvimbela izinkinga ezifana nezilonda. Yingakho ukulandela okulandelanayo nodokotela wakho kuqakathekile-ngakho-ke uhlelo lokuphathwa ngokucophelela lungenziwa futhi luguquke njengoba kudingeka.
Okufanele Ukwazi Ngaphambi Kokuthatha i-PPIs
Ngo-2012, i-FDA yakhipha isixwayiso kubathengi abasebenzisa i-PPIs bangase bahlobaniswe nengozi yokutheleleka, njenge-pneumonia, kanye nohudo oluhlobene neClostridium difficile. Ukwelashwa nge-bacterium Clostridium difficile kubangela izikhumba, ubuhlungu besisu, nomkhuhlane.
Ukwengeza, ama-PPIs ahlotshaniswa nokuqhathaniswa kwe-calcium encane kanye nengozi eyengeziwe yokwehlukana kwamathambo (kubantu abathwala ama-PPIs-okusho okungaphezu kwesisodwa ngosuku kanye nonyaka noma ngaphezulu).
Iphinde ihlotshaniswe nokwehliswa kwe-magnesium emanzini, ngakho udokotela wakho angase ahlole izinga lakho le-magnesium ngezikhathi ezithile.
Izwi elivela
Kubaluleke kakhulu ukuthatha noma imiphi imithi, kuhlanganise neproton pump inhibitors, ngaphansi kokuqondiswa udokotela, noma ngabe iyatholakala ngaphezulu kwe-counter. Lokhu ukuqinisekisa ukuthi i-proton pump inhibitor ithathwa ngokunembile futhi ngenxa yezizathu ezifanele-ukuxilongwa okufanelekile kuyisihluthulelo, njengoba kunezinkinga zempilo eziningana ezingalingisa i-GERD.
Imithombo:
> I-American College ye-Gastroenterology. (Juni 2008). Izinkinga ezivamile ze-GI Umqulu 1: Ukuqonda Omunye WamaMithi Ovame Ukushiwo I-GERD & Ulcers.
> Johnson, T. (June 2014). Ukuphathwa kwe-US nokudla izidakamizwa: Ukusetshenziswa kwe-Proto Pump Inhibitors kanye nengozi ye-Bone Fractures kubantu abadala.
> Katz, PO, Gerson, LB, Vela MF Izinkombandlela zokuxilongwa nokuphathwa kwe-reflux isifo se-gastroesophageal. Am J Gastroenterol. 2013 Mar; 108 (3): 308-28.
> Lanza, FL, Chan, FK, Quigley, EM, iKomiti Yokuzijwayeza I-American College of Gastroenterology. Iziqondiso zokuvimbela izinkinga zesilonda ezihlobene ne-NSAID. Am J Gastroenterol. 2009 Mar; 104 (3): 728-38.
> Ukuphathwa Kwezokudla Nezidakamizwa zase-US. (Febhuwari 2012). I-FDA Ukuphepha Kokuphepha Kwezidakamizwa: I- Clostridium difficile- isifo sohudo esingahlanganiswa singahlanganiswa nezidakamizwa ze-acid esiswini okuthiwa i-proton pump inhibitors (PPIs).