Ukusebenzisa isikhathi eside noma ukusetshenziswa ngokweqile kuxhumene nezifo ezimbi
I-Proton pump inhibitors (i-PPIs) yiqembu lezidakamizwa ezinomgomo wokunciphisa isisu se-isisu. Sezisetshenziselwe ukwelapha izifo eziningi ezihlobene ne-acast gastric iminyaka engaphezu kwengu-20 futhi ziyaziwa ziphephile futhi zisebenzayo-kakhulu kangangokuthi ziye zafakaza kakhulu izivimbela ze-H2 njengezidakamizwa ezizikhethelayo.
Lokhu akusho ukuthi i-PPIs ayinayo izinselele noma ukulinganiselwa kwabo.
Ngenkathi iningi lemiphumela emibi lumnene futhi liphathekayo, kunezenzakalo eziningi ezimbi ezingenzeka ngokusetshenziswa kwesikhathi eside noma ngokweqile. Lokhu kufaka phakathi izinkinga zokumunwa kwamaminerali, izinguquko ekutheni amandla amathambo, kanye nengozi eyengeziwe yezifo ezithile ezingapheli.
Indlela iProtton Pump Inhibitors Esebenza ngayo
Ama-proton pump inhibitors ajwayele ukusetshenziselwa ukwelapha izifo ezifana nesifo se-reflux se-gastroesophageal (GERD) , izilonda ze-peptic , kanye nesifo sokuphefumula , odokotela bangase babone ukusebenzisa i-PPIs yedwa noma kuhlangene nama-antacids. Zingasetshenziswa futhi ngokuhambisana nama-antibiotics athile uma ukwelapha i- Helicobacter pylori (ibhaktheriya evame ukuhambisana nezilonda zesisu eziphindaphindiwe).
Ama-PPI asebenza ngokubopha esitokisini odongeni lwesisu okuthiwa i-parietal cell enenhloso yokukhiqiza i-hydrochloric acid (HCL). Ngokwenza kanjalo, isisu asikwazi ukuhlanganisa i-HCL, ivumela izilonda ukuba ziphulukise futhi zifake amandla.
Ama-PPI ahlukile kuma-block block eH2 kulawo ma-PPI avaliwe amaphampu ase-acid ngenkathi i-H2 blockers ivimba kuphela isignali edala ukukhiqizwa kwe-acid. Ngenxa yalokhu, ama-PPI asebenza amahora angaba ngu-24 futhi anikeze ukuphumula amahora angama-72. Abasebenzi be-H2, ngokuphambene, sebenze amahora angu-12.
Izinhlobo ze-Proton Pump Inhibitors
Ngokuvamile, i-PPI eyodwa ayifani nhlobo nokunye okuningi kusuka kwabanye.
Bonke banezinhlelo ezifanayo zesenzo kanye namanani afanayo okusebenza. Okwamanje ama-PPI avunyelwe afaka:
- I-Prilosec (i-omeprazole)
- I-Prevacid (i-lansoprazole)
- I-Protonix (i-pantoprazole)
- I-Aciphex (i-rabeprazole)
- I-Nexium (esomeprazole)
- I-Dexilant (dexlansoprazole)
Naphezu kokufana kwazo, ama-PPI athile abhekwa njengendlela ephumelelayo ekwelapheni izimo ezithile. Isibonelo, i-Dexilant ne-Protonix ayisetshenziselwa ukuphatha i- H. pylori ukutheleleka; ezinye zikhona. Ukuze uthole usizo lokuphumula ngokweqile, i-Prilosec ne-Prevacid kunconywa lapho abanye bengekho khona. Ngenxa yalokho, kubalulekile ukukhuluma nodokotela wakho ukuqinisekisa ukuthi ukusetshenziswa kwe-PPI kulungile.
Imiphumela emibi nokusebenzisana
Uma kuthathwa isikhathi esifushane, iningi lemiphumela emibi ehlobene ne-PP! ukusetshenziswa kuyamnene futhi kwesikhashana. Okuvame kakhulu kuhlanganisa ukudliwa, isifo sohudo, isifo sofuba, isisu, isisu esidabukisayo, isicashu, nokuhlanza.
ubufakazi obukhulayo bubonisa ukuthi ukusetshenziswa kwesikhathi eside kungabangela izinkinga ezinkulu. Phakathi kwazo:
- Kuye kwaphakanyiswa ukuthi ukusetshenziswa kwe-PPI kungaphazamisa ukumuncwa kwe-calcium, okuholela ekutheni amathambo aphuke kwezinye izimo. Ephendula, i-US Food Administration and Drug Administration yanikeza izixwayiso ngo-2011 eluleka ukuthi ama-PPIs angaphezu kwamakhompiyutha kufanele asetshenziswe isikhathi esingaphezu kwamaviki amabili ngesikhathi sokuthola izinyanga ezintathu ngonyaka.
- Ukusetshenziswa kwe-PPI yesikhathi eside kuye kwahambisana nokunyuka okuncane emngciphekweni we-pneumonia othola umphakathi kanye nokutheleleka kweClostridium difficile .
- Ucwaningo luye lwabonisa ukuthi ukusetshenziswa kwama-PPIs eminyakeni engaphezu kwengu-10 kunengozi ye-12.5% ​​yokuthuthukisa isifo esingenasifo sezinso, esiphezulu kunamaphesenti angu-8.5 abonakala kubantu abaningi.
- Ucwaningo olunjalo luphakamisa ukuthi abantu abathatha ama-PPIs eminyakeni engaphezu kwesikhombisa babe nethuba elingamaphesenti angu-13 lokuthola ukucindezeleka komzimba uma kuqhathaniswa nalabo abangazange bawenze.
Eziningi zalemiphumela emibi zibonakala zixhunywe neqiniso lokuthi ama-PPI akagcini nje ukuvala amaphampu ase-acid esiswini kodwa nasemzimbeni wonke, futhi.
Lokhu kufaka ingxenye yengqamuzana ebizwa nge-lysosome esebenzisa i-asidi ukususa imfucuza. Ngaphandle kwendlela yokwenza kanjalo, i-waste ingakwazi ukuqoqa futhi ibangele ukuthi iseli liwohloke futhi likhule. Lesi simo singabika ngokukhuphuka okubonwe ezifundweni.
Izinto ezitholakalayo ziqokomisa iqiniso lokuthi ama-PPIs kufanele asetshenziswe kuphela ekusizeni isikhathi esifushane noma ukwelashwa kunokuba kube indlela yokuvimbela izifo zesisu esiswini eside.
> Umthombo
- > UJacob Schoenfeld, J. noGridy, D. "Imiphumela Embi Ehlanganiswa Ne-Proton Pump Inhibitors." Umagazini we-American Medical Association. 2016: 176 (2): 172-174.