Ukuphathwa Kwezifo Ingabe Injongo
I-Gout iyindlela ehlukumeza kakhulu ye-arthritis. Abantu abaningi abaye bahlaselwa yi- gout bachaza lokho okuhlangenwe nakho okubaluleke kakhulu, futhi empeleni, bayokwenza noma yini ukuze baqinisekise ukuthi abanakho. Bafuna ukwazi indlela yokwelapha i-gout, kodwa ingabe kukhona ngempela ukwelashwa?Iyini Imithi?
I-Merriam-Webster Dictionary ichaza ukwelashwa ngokuthi "ukuphulukiswa kwesifo; ukuxolelwa kwezibonakaliso noma izimpawu zesifo ikakhulukazi ngesikhathi sokubheka isikhathi eside."
Ngokuhambisana naleso ncazelo, ukwelashwa kwe-gout kubonisa ukuthi ukwelashwa ngokuphumelelayo kuvimbela ukuphindaphindiwe kokuhlasela kwe-gout. Ukuze baphulukiswe, iziguli zogulane kufanele ziphendule kahle ekwelapheni futhi zihambisane nesicwangciso sokwelapha isikhathi eside.
Ukuhlaselwa kwe-gout kuvela njengama- uric acid amaningi ngokweqile emzimbeni nasekristini (i-monosodium urate monohydrate crystals noma i-MSU) futhi ifakwe emajoyini nasezicubu ezithambile ezizungezile amalunga. Ukufakwa kwe-crystals kuhlanganiswe nokuvuvukala okunzima nokuhlala njalo.
Akubona bonke abantu abane- hyperuricemia abahlakulela i-gout: kulinganiselwa ukuthi kuze kube yizingxenye ezimbili kwezintathu zabantu abane-hyperuricemia akalokothi athuthukise izimpawu zamakristalu noma ama- gout . Noma kunjalo, umgomo wokwelapha isikhathi eside ukugcina i-serum uric acid engaphansi kuka-6 mg / dl. Kulelozinga, amakristalu amasha ayakha, ama-crystals akhona angaqedwa, ukuhlasela okunamandla kwe-gout kuvinjelwe, futhi i-tophi igxumeke futhi iphele.
Ngokuyinhloko, uma i-uric acid igcinwa ngezansi kwe-6 mg / dl, futhi yonke i-crystal deposits ichitheka, igciwane liyaphulukiswa - nakuba kungekho ukwelashwa okuqhubekayo, iningi labantu lizobuyela emuva.
Ukuhlaselwa kwe-Gout okungavunyelwe
Ngokuqala kokugaya, ubuhlungu nokuvuvukala kunamandla kakhulu phakathi kwamahora ambalwa okuqala.
Ngisho noma kungalashwa, izimpawu zivame ukuthuthukisa ezinsukwini ezimbalwa, mhlawumbe kuthatha amasonto ambalwa. Kwabanye abantu, ukuhlaselwa kwe-gout okulandelayo kungase kube khona, kanye neminyaka phakathi kokuhlaselwa. Njengoba isikhathi siqhubeka, ukuhlasela kwe-gout kuvame ukukhula kumvamisa. Ukuhlasela ngalunye kungadlulela isikhathi eside futhi kungafaka amalungu amaningi.
Ukuphatha i-Gout nokuvimbela ukuphindaphinda kokuhlaselwa
Inhlanganisela yemithi kanye nezinguquko zokudla ngokuvamile isetshenziselwa ukuvimbela ukuhlaselwa kwe-gout, noma kwezinye izimo, ukunciphisa imvamisa yokuhlasela kwe-gout. Ukunciphisa amazinga e-uric acid ngokuvamile umgomo.
Abantu abanokuhlasela okungajwayelekile noma okunamandla kungase kungadingi imithi yokuvimbela isikhathi eside, futhi bangathola ngokuphatha ukuhlasela okunzima njengoba kwenzeka. Kodwa abantu abahlaselwa yi-gout njalo, isikhathi eside nokukhubaza kungadinga imithi yokulawula ukuphindaphindiwe.
Ama-NSAID (izidakamizwa ezingavumeli ukuvuvukala) azibhekwa njengendlela yokuqala yokuzivikela ekuhlaselweni kwe-gout, ngaphandle kokuthi izidakamizwa ziphikisana ngenxa yokungabi namandla noma umlando wezilonda eziphaphayo , isibonelo. Ngokuvamile, ama-NSAID angaletha ukuhlasela kwe-gout ngaphansi kokulawula zingakapheli amahora angu-24.
I-glucocorticoids , ebizwa nangokuthi i-corticosteroids, iyindlela ephumelelayo yesibili yokuzivikela ngokuhlasela okunamandla kwe-gout.
Ngokuvamile, lezi zidakamizwa zinqunywe ngomthamo ophezulu ekuqaleni, bese zithinta izinsuku ezingu-10 kuya kwezingu-14. Ngenxa yemiphumela emibi , i-corticosteroids yikhambi lesikhashana, hhayi isikhathi eside.
UColchicine wayekade engumuthi ozikhethela ukuphatha ukuhlasela okunamandla gout. Ngenxa yesikhathi esithatha ukulawula ukuhlaselwa kanye nekhono lokwelashwa, i-colchicine ayisasetshenziselwa ukuphatha ukuhlasela okunamandla kwe-gout, kodwa kusasetshenziselwa ukuyivimbela.
Uma kunqunywe ukuthi isiguli kufanele siphathwe ngesidakamizwa esinciphisa umcuba, kunezinhlobo ezimbalwa zokukhetha. I-Allopurinol yi-inhibitor ye-xanthine oxidase eyanciphisa ukukhiqizwa kwe-uric acid.
I-Probenecid ingenye yamakhemikhali we-uricosuric okwandisa ukwanda kwe-uric acid.
I-uloric (i-febuxostat) iyisidakamizwa esinikezwe ukuphathwa kwe-hyperuricemia engapheli gout. I-uloric yehlisa i-serum uric acid ngokuvimbela i-xanthine oxidase (i-enzyme ehilelekile ekukhiqizeni uric acid).
I-Krystexxa (i-pegloticase) yisidakamizwa se- biologic esitholakalayo ezigulini ezingenakuzithatha, noma abangabasizwa yizo, izifo zokwelapha ezivamile . I-Krystexxa isebenza ngokuphula i-uric acid.
Imithombo:
Ulwazi lwesineke: I-Gout (Ngaphandle Kwezinto Eziyisisekelo). Kusesikhathini. UMichael A. Becker. Ngo-Mashi 29, 2012.
http://www.uptodate.com/contents/gout-beyond-the-basics?source=search_result&search=Gout+beyond+the+basics&selectedTitle=1%7E150
Ukwelapha ukukhomba: amasu okuphulukisa umuthi. UFernando Perez-Ruiz. I-rheumatology. 2009.
http://rheumatology.oxfordjournals.org/content/48/suppl_2/ii9.full
I-Primer kuma-Rheumatic Diseases. Klippel, J. et al. Ishicilelwe yi-Arthritis Foundation. Umshicileli weshumi nantathu.