Ososayensi manje bathola izixhumanisi zezakhi zofuzo ekukhulupheni. Esinye isakhi sofuzo, esaziwa ngokuthi yi- FTO, sibonwe njengenhlangano ecacile yokukhuluphala.
Ukukhuluphala kwe-Master Switch
Abacwaningi bathole manje ukuthi isakhi sofuzo se-FTO singabamba isihluthulelo sokuthi yibaphi abantu ababhekene nokukhuluphala ngokweqile.
Ngokwesibonelo, ososayensi bathole ukuthi isakhi sofuzo se-FTO singenza umkhuba wokudla nokudla ngokweqile ebusheni .
Futhi ekucwaningweni kweziguli ezingaba ngu-1 000 eNingizimu Afrika, ososayensi bathola izimpawu ezine zofuzo (enye yazo eyabandakanya i-Genetic FTO) ehlotshaniswa ne-BMI ephakeme eneminyaka engu-13.
Olunye ucwaningo olubheka imiphumela ye-FTO ezinganeni ezingaphezu kuka-3 000 zaseShayina zathola ukuthi imiphumela ye-FTO kwi-BMI ephakeme nayo yaholela engozini ehambisanayo yokucindezelwa kwegazi (i-hypertension), eyaziwa ukuthi ibangelwa ukukhuluphala.
Igayela le-FTO libonakala lihlotshaniswa nemiphumela yokudla, ukudla kokudla, kanye nenani le-mass mass (BMI). Ngokusekelwe emiphumeleni yamuva yocwaningo, abacwaningi manje bakholelwa ukuthi kungenzeka kube nobuhlobo phakathi kwe-FTO, ukudla nge-binge, nokukhuluphala. Abanye baye bafika ukubiza iFTO ngokuthi "mastermind" uma kuziwa ekulawuleni izakhi zofuzo nokuzimisela kwekusasa le-BMI.
Indlela i-FTO engakwazi ngayo "Vula" ukukhuluphala
Izinhlobo ezithile zezakhi zofuzo (cabanga ngalezi zinguqulo "ezihlukile" zesiginja esifanayo esingathola ifa) zegciwane le-FTO zitholakale ukuthi azihlanganiswa nje ngokukhuluphala kodwa nomdlavuza kanye-futhi, ngokuphawulekayo, izinhlobo eziningi zomdlavuza ukukhuluphala-okuhlobene , futhi.
Emiphakathini, abacwaningi baye baqaphela ukuthi ukukhathazeka okuthile kwemisebenzi ye-enzyme ehlobene ne-FTO kungavula noma kuvaliwe ukushintshwa kwezinye izakhi zofuzo ezilawula umzimba. Lokhu, kungabangela ukugcina amafutha ngendlela engafanelekile, noma "nokunciphisa umzimba". Lokhu kungase kuholele ku-Type 2 yesifo sikashukela, esinye isifo esithinta ukukhuluphala.
Abacwaningi bathole nokuthi ukuphatha izindawo ezithile zegciwane le-FTO kungashintsha isisindo somzimba kanye nesimetabolism kumagundane, kufaka phakathi indlela i-fat egcinwe ngayo-ngaphandle kokushintsha kokusebenza komzimba noma ukudla.
I-Genetic Therapy Yokuphatha Ukukhuluphala
Yize kungekho nhlobo yokwelashwa kwezakhi zofuzo okwamanje ekhona ekwelapheni ukukhuluphala, ososayensi banethemba lokuthi ukutholakala okunjalo kwezakhi zofuzo njenge-FTO "gene gene" kuzoholela ekuhlosweni kokwelashwa kwesikhathi esizayo. Ngaphambi kwalokho, kuningi okunye okumele kufundwe mayelana nezakhi zofuzo ngemuva kokukhuluphala.
Imithombo:
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USomemo S, Tena JJ, Kim KH, Gamazon ER, et al. Izinhlobonhlobo ezihambisana nokukhuluphala ngokweqile ngaphakathi kweFTO ifomu elide lokuxhumana okusebenzayo ne-IRX3. Imvelo 2014; 507: 371-5.
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Zhao X, Yang Y, Sun BF, Zhao YL, Yang YG. I-FTO nokukhuluphala: izindlela zokuhlangana. I-Curr Diab Rep 2014; 14: 486.