Incazelo, izici ze-Mantle Cell Lymphoma
Iyini i-mantle cell lymphoma, futhi yini okufanele ngiyiqonde ngalolu hlobo lomdlavuza?
Sibutsetelo
I-Mantle Cell Lymphoma uhlobo olungavamile lwe-non-Hodgkin's lymphoma (NHL) . Kuphela ku-5-7% ku-NHL kuphela kulelo qembu. I-lymphoma ye- B lymphocyte, noma i- "B-cells". Nakuba kubonakala sengathi i-tumor ekhulayo, ephansi kakhulu ngaphansi kwe-microscope, ivame ukukhula ngokushesha futhi iziphatha njenge-high-grade lymphoma.
Ibizwa ngokuthi 'i-mantle' cell lymphoma ngoba kuqala ivela ngaphakathi kwengxenye ye-lymph node ebizwa ngokuthi indawo 'yezimpahla'.
Izingozi Zezingozi
I-Mantle Cell Lymphoma ivame kakhulu emadodeni kunabesifazane nakubantu abadala. Isikhathi esiphezulu sokuxilongwa singaphezu kweminyaka engama-60. Azikho izinkinga ezicacile zokuthola lolu hlobo lwe-lymphoma, nakuba izici eziningi ezivela ekutheleleni kwamakhemikhali ziye zabhekwa njengoba kungase kubonakale ingozi ye-non-Hodgkin's lymphoma ngokujwayelekile.
Izimpawu
I-Mantle cell lymphoma iqala emagqumeni lymph. Into yokuqala abantu abaningi bayayiqaphela ama-node ekhulisiwe entanyeni, ekuguleni noma emagqumeni. Lesi sifo sikhula ngokushesha futhi ngesikhathi siboniswa udokotela, lesi sifo sesisakaze kwezinye izitho emzimbeni. Kwabanye abantu lesi sifo sikhula kancane, into onologists ibizwa ngokuthi "indolent" kodwa lokhu kuyinto ehlukile. Umnkantsha wamathambo, i-spleen, ne-throat yathinteka kubantu abaningi, futhi ngokuvamile kuvame ukuba ne-lymphoma amangqamuzana egazini.
Amathumbu nawo angathinteka kwabanye abantu, futhi aveze izimpawu ezifana nobuhlungu besisu noma isifo sohudo.
Ukuxilongwa
Izivivinyo ze-Mantle cell lymphoma zifana nalezo zezinye izinhlobo ze-lymphoma. Zihlanganisa ukuhlolwa kwegazi, ukuhlola kanye nokuhlolwa komnyofu wamathambo . Uma izivivinyo ziveza ukuthi yiziphi izingxenye zomzimba ezithintekayo, isigaba sesifo singanqunywa .
Iningi labantu linesifo sesigaba se-III noma IV esasakazekele ezithombeni ezihlukene zomzimba.
Ukwelapha
I-Mantle cell lymphoma iphathwa ngokuyinhloko nge-chemotherapy, kodwa ukuthi iphathwa kabi kangakanani incike kakhulu ekudala. Abantu abadala, abanempilo enempilo, i-chemotherapy elandelwa yi-stem cell transplant ingaba yindlela enhle, kodwa ihlanganisa ubuthi obukhulu. Ukwelashwa kuvamile ngaphandle kokuthi lesi sifo sitholakale kusenesikhathi, futhi inhloso yokwelashwa ukugcina lesi sifo silawulwa isikhathi eside ngangokunokwenzeka. Izindlela eziningi zokwelashwa zihlanganiswa neRituxan (rituximab) futhi le mithi ingasetshenziselwa ukugcinwa kokwelashwa okulandelayo.
Imithi emisha efana neVelcade (bortezomib) ne-Treanda (bendamustine) yindlela ehlukile kulezi zinhlobo ze-chemotherapy. Inhlanganisela eminingi yezidakamizwa kanye nezidakamizwa ezintsha zifundiswa ekuvivinyweni kwemitholampilo, futhi kungenzeka ukuthi izinqubo ezintsha zokwelapha kanye nokwelashwa kwe-mantle cell lymphomawill zizotholakala esikhathini esizayo esiseduze.
Njengoba lesi sifo sivame ukuqhubekela phambili, ukwelashwa okunjengokuhlinzwa kanye nokwelashwa kwamafutha ngokuvamile kunendima encane kuphela.
Ukubhekana
Ukubhekana nokuxilongwa okusha kwe-lymphoma kungaba yingozi kakhulu. Kufanele uqale kuphi lapho utholakala khona kuqala? Kwabanye abantu, ukwelashwa okunonya kungaba yindlela engcono kakhulu.
Kwabanye, ukwelashwa okunonya kungase kungabi yisinqumo esihle kakhulu. Noma kunjalo, kusekhona ithemba lekhwalithi elihle lokuphila kanye nesikhathi onayo. Hlola lezi zeluleko zokubhekana nomdlavuza wokugcina . Finyelela emndenini nabangani . Kunomphakathi omkhulu wokusekela wabantu abane-lymphomas ku-inthanethi kulabo abafisa ukusekelwa kwabanye abathola okuthile okufanayo. Futhi khumbula ukuthi ucwaningo luqhubeka, nokuthi kukhona ukuthuthukiswa okuthembisayo kakhulu okwenziwe ekwelapheni komdlavuza namuhla.
Imithombo:
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UDreyling, M., Ferrero, S., kanye ne-European Mantle Cell Lymphoma Network. Indima yokwelashwa okuhlosiwe ku-mantle seli lymphoma: ukufakelwa kokufa noma okuphilayo? Haematologica . 2016. 101 (2): 104-14.
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