Itiye elihlaza (Camellia sinensis) lingase libe nezinzuzo zezempilo ezibandakanya ukuvimbela i-arthritis. Imiphumela yocwaningo ebikwe kwi-Proceedings of the National Academy of Sciences (1999) yiyokuqala ukubonisa ukuthi ama-antioxidants athola itiye elihlaza, eyaziwa ngokuthi i-polyphenols, anganciphisa ngokuphumelelayo izigameko nokuqina kwesifo samathambo .
Ithimba Elimnyama Elimnyama Efundweni Lokuqala
Ucwaningo oluholwa nguDkt. Tariq Haqqi weCape Western Reserve University eCleveland, eOhio, wasebenzisa amagundane ukuze atadishe umphumela we-polyphenols e-rheumatoid arthritis, isifo esibangela ukuvuvukala , ubuhlungu, ukuvuvukala nokubhujiswa okuhlangene.
Amagundane ekucwaningweni anikezwa ngamanzi alula noma amanzi athengiswa itiye eluhlaza. Izilinganiso ezinikeziwe zazifaniswa nokusetshenziswa komuntu kwezinkomishi ezine zeti elihlaza ngosuku. Zonke amagundane zabe sezijojowe nge-collagen ngenhloso yokunciphisa i-arthritis. I-arthritis eyenziwe nge-collagen ibhekwa kakhulu efana ne-arthritis yabantu.
Imiphumela yokucwaninga yaphetha ngokuthi amagundane ayedla i-tea tea polyphenols ayengenakuvuthwa kakhulu ekuthuthukiseni i-arthritis eyenziwa yi-collagen kunezinkoma ezingadli i-tea tea polyphenols. Ezimpukeni zondla itiye elihlaza okwakusungula i-arthritis, kwenzeka njengasekuqaleni kokuqala futhi kunomusa. Amagundane ayisishiyagalolunye kuphela ku-18 athola i-tea ye-polyphenol eluhlaza okwesibhakabhakeni, kanti ama-17 angaphezu kwengu-18 ayengawutholi i-tea tea polyphenol yahlakulela i-arthritis.
Ukuhlolisiswa kwezicubu ezihlangene kubonakalisiwe ukungena kwamangqamuzana ahlangene emasimini athola itiye eluhlaza ngokuphambene nokungena okukhulu kwamagundane angadli itiye elihlaza.
Umphumela weti elihlaza kubonakala kakhulu.
Emazweni amaningi afana neNdiya, iChina neJapane, itiye eluhlaza ithathwa njengenempilo enamandla okuvimbela izifo ezithile. Kubonakala sengathi i-arthritis ye-rheumatoid kula mazwe ikhona ngesilinganiso esincane kakhulu kunezinye izindawo emhlabeni jikelele kanti abanye abantu bakholelwa ngokuqinile emthonjeni wetiyi eluhlaza.
I-EGCG (i-epigallocatechin-3-gallate) i-polyphenol itiye elihlaza elibhekwa njengesithako esisebenzayo. Ngokombiko we-Arthritis Research & Therapy (2010), i-EGCG ihlanganisa ama-catechine angu-63%. Ngokomsebenzi we-antioxidant, i-EGCG inamandla angu-25 kuya ku-100% ngaphezulu kunevithamini C noma i-vithamini E. Enye indebe yetiyi eluhlaza inikeza amakatekini angu-60 kuya ku-125 mg (kufaka phakathi i-EGCG).
Umphumela we-EGCG kuma-Synovial Fibroblasts
Yonke leyo minyaka edlule, izinzuzo zezempilo ezithinta itiye oluhlaza zathatha ukunakwa kwabacwaningi ngokushesha. I-in vitro (okungukuthi, e-laboratory) izifundo zaqhutshwa. Ngonyaka ka-2007, eminyakeni engaba ngu-8 emva kokutadisha kokuqala, itiye eliluhlaza laliphinde lenze isihloko. Okwamanje, abacwaningi eYunivesithi yaseMichigan bathola ukuthi i-compound itiye elihlaza lingasiza ekuvimbeleni ukuvuvukala kanye nokulimala okuhlanganyelwe kweziguli ze-rheumatoid arthritis.
Kulesi sifundo, ama-synovial fibroblasts (amangqamuzana egumbini elihlangene) ayesehlukanisiwe futhi akhuliswa. Amaseli avuliwe ku-EGCG. Kwakunqunywe ukuthi i-EGCG ivimbele ama-molecule amabili ahlotshaniswa nokwehla kwamathambo emajoyini abhekene nesifo se-rheumatoid arthritis. I-EGCG iphinde ivimbele i-prostaglandin E2 ekhishwa yizindonga zamanzi ezitsheni ekuphenduleni ukutheleleka noma ukuvuvukala.
I-Prostaglandin E2 ihlotshaniswa nokuvuvukala okuhlangene.
Izivivinyo zemitholampilo ze-EGCG
Ukuphumelela kwe-EGCG ku-arthritis ye-rheumatoid arthritis noma i- osteoarthritis ngokusebenzisa izilingo ezilawulwa yizinhlangothi akukaze kwenziwe. Ngenkathi izifundo ezikhona e-vitro zibonise ubufakazi bokusebenza okungahambisani nethrafikhi ye-EGCG, kudingeke ucwaningo oluningi olwalufanelekile futhi ekugcineni, ukuvivinywa kokwelashwa okubandakanya iziguli ezinezifo ezihlangene.
Imithombo:
Ukuqhubeka kwe-National Academy of Sciences, 1999; 96: 4524-4529
Itiye elihlaza litholakala ukulula ukuvuvukala, ubuhlungu be-arthritis. NaturalNews.com. UDavid Gutierrez. Disemba 31, 2007.
I-polyphenol epigallocatechin e-Green teat 3-gallate ku-arthritis: inqubekela phambili nesithembiso. Salahuddin Ahmed. I-Arthritis Research and Therapy. April 2010.