I-Methimazole, i-Carbimazole ne-Propylthiouracil / i-PTU
Uma igciwane le-thyroid liba namandla kakhulu - isimo esaziwa ngokuthi i-hyperthyroidism - i-gland iveza i-hormone ekhulu kakhulu yegciwane. Lokhu nakho kungabangela izimpawu ezihlukahlukene, kufaka phakathi ukushayela okusheshayo, ukucindezeleka okukhulu kwegazi, ukukhathazeka, ukushona, ukuthuthumela, ukulahlekelwa isisindo, isifo sohudo, kanye nezinqwaba zezibonakaliso zokungasebenzi ngokweqile, nezithobezi ezingaphezu kokusebenza kanye nezitho.
Ukwelashwa okubalulekile kwe-hyperthyroidism kuyisigaba semithi yokudokotela ebizwa ngokuthi izidakamizwa ze-antithyroid. Izidakamizwa ze-Antithyroid nazo zibizwa ngokuthi ama-thioamide. Ziyizidakamizwa ezisetshenziselwa ukwelapha i-thyroid engasebenzi - i-hyperthyroidism - kuhlanganise nalapho i-thyroid ingasebenzi ngokweqile ngenxa yesifo se-Graves, i-goiter ye-toxicular goiter, noma ama-nodules ezinobuthi.
Izidakamizwa ze-Antithyroid zisebenza ngokuvimbela ikhono legciwane le-thyroid ukukhiqiza ama-hormone amabili ekhanda thyroxine (T4) ne-triiodothyronine (T3).
Izidakamizwa ezibalulekile ze- antithyroid e-United States zitholakala i-methimazole ne-propylthiouracil (PTU). Ngaphandle kwe-United States, izinqumo ziyi-methimazole, i-carbimazole, ne-PTU.
I-Methimazole
Umuthi we-antithyroid we-methimazole uvimbela i-thyroid ngokusebenzisa i-iodine - ngokuvamile kusuka ekudleni noma ekugcineni-ukukhiqiza i-hormone ye-thyroid. Kuyinto imithi ngokuvamile ethathwa kanye ngosuku iziguli.
Ngezinye izikhathi i-Methimazole ibizwa ngegama elithi thiamazole.
Lesi sidakamizwa sisetshenziswe emhlabeni wonke futhi yisisetshenziswa esiyinhloko se-antithyroid esetshenziswa e-United States, lapho itholakala ngaphansi kwegama elithi Tapazole.
Abakhiqizi abaningana banikeza uhlobo olujwayelekile lwe-methimazole.
I-Carbimazole
I-Carbimazole iyisidakamizwa ukuthi, uma isetshenziswa, iguqula ibe yimithi ye-methimazole emzimbeni, ngakho-ke iyasebenza ngokufanayo.
Umkhiqizo owaziwayo kakhulu we-carbimazole yi-Neomercazole.
I-Neomercazole yigama lomkhiqizo we-carbimazole futhi lenziwe yi-Amdipharm International (UK). Lesi sidakamizwa sagunyazwa ngo-2004, futhi sithengiswa e-UK naseYurophu, kodwa ayitholakali noma esinqunyiwe e-United States. Ungabona i-datasheet ku- Neomercazole lapha. Nazi izinsiza eziningana ezengeziwe mayelana ne-Neomercazole.
- Iwebhusayithi Yomenzi Wezidakamizwa: Amdipharm
- Ukubeka imininingwane
Neomercazole Izithako : i-carbimazole Ph.Eur; i-lactose; isitashi sommbila; i-sucrose; i-magnesium stearate; i-sucrose; i-talc; i-gum acacia; i-ferric oxide; propyl hydroxybenzoate; kanye ne-gelatin.
Amandla atholakalayo : 5 mg
Amanye amabhizinisi / amagama: I- Carbimazole itholakale emazweni athile aseYurophu nase-Asia ngaphansi kwamagama elandelayo: Atirozidina, Basolest, CG1, Carbimazole Spofa, Carbotiroid, Mertiran, Neo-Mercazole, Neo-Thyreostat, Neo-Tireol naseTyrazol.
I-Propylthiouracil / PTU
Indlela i-PTU yenza ngayo i-hormone ye-thyroid ye-thyroid yokuvimbela ngokweqile ukuthi ivimbela igciwane le-thyroid ngokusebenzisa i-iodine ukukhiqiza i-hormone ye-thyroid. Kuvimbela nokuguqulwa kwehomoni ye-thyroid ye-T4 ibe yi-T3. I-PTU inezinkathi zesikhathi esifushane, ngakho-ke iziguli ezithatha le mithi ngokuvamile ziyalwa ukuba zithathe imithi kabili kathathu ngosuku ukuze ihlise ama-hormone wegciwane ephansi.
I-PTU inemiphumela emibi kakhulu kunezinye izidakamizwa ezikhulunywe lapha, futhi yisidakamizwa esithandwayo se-hyperthyroidism kuphela ezimweni ezimbalwa (ngesikhathi sokukhulelwa kokuqala, isiphepho esinamandla se-thyroid futhi lapho kwenzeka isiguli sibhekene nemiphumela emibi kakhulu evela ku-methimazole).
E-United States, i-PTU ejwayelekile kuphela iyatholakala; awekho amagama e-PTU athengiswe e-United States. Inani labakhiqizi likhiqiza i-PTU ejwayelekile.
Ulwazi olungaphezulu
Funda kabanzi mayelana ne-hyperthyroidism nemithi yayo, kuhlanganise nezidakamizwa ze-antithyroid, kulezi zinsiza:
- Hyperthyroidism | Izifo Zama-Graves | I-Thyroid engasebenzi
- Izifo zamathuna kanye ne-Hyperthyroidism 101
- I-Hyperthyroidism Risks / Symptoms Checklist
- Izingozi zeMathuna Amathuna kanye ne-Hyperthyroidism
- Imibuzo Evame Ukubuzwa Nge-Hyperthyroidism ne-Graves '
- 3 Izindlela Zokuphatha Hyperthyroidism
Imithombo:
I-Med Med, I-US Yokudla Imithi Yezokudla Nezidakamizwa, ku-intanethi
I-FDA Ukuphepha Kokuphepha Kwezidakamizwa: Isixwayiso Esisha Sokuxwayiswa Kokulimala Okuqinile kwesibindi no-propylthiouracil, ngo-Ephreli 21, 2010, ku-intanethi
Ross, Douglas MD, "Ulwazi lokubekezela: izidakamizwa ze-Antithyroid," UpToDate . Kugcine ukubuyekezwa: Novemba 13, 2009