Imithi ye-Cancer inikeza umphumela wokulwa nokuvuvukala kwezifo ze-rheumatic
Imishanguzo ye-cytotoxic esetshenziselwa ukuphatha izifo zesifo sofuba ihlanganisa:
- I-Azathioprine (Imuran)
- I-Cyclophosphamide (i-Cytoxan)
- I-Methotrexate (i-Rheumatrex noma i-Trexall)
Lezi zidakamizwa zazibizwa ngokuthi "i-cytotoxic" ngoba ziphatha izidakamizwa ngokubulala ngokuqondile amaseli amathumba. Ukukwazi kwabo ukusiza izibonakaliso nezinye izifo, njenge- rheumatoid arthritis , i-lupus ne- vasculitis kungenzeka, kodwa ngenxa yemiphumela yabo ephikisanayo nokungafani nokukwazi ukubulala amaseli.
Eqinisweni, umthamo ophansi we methotrexate osetshenziselwa ukuphatha lezi zimo empeleni ukulwa nokuvuvukala futhi hhayi cytotoxic.
Izinzuzo kanye Nezingozi Zezidakamizwa Ze-Cytotoxic for Rheumatic Diseases
I-Cytoxan
Kulezi zidakamizwa ezintathu, i-Cytoxan inemiphumela emibi kunazo zonke futhi ngokuvamile inomkhawulo wokwelapha izimo ezinzima ze-lupus, vasculitis, noma isifo se-lung lapho ngezinye izikhathi kuhlotshaniswa ne-arthritis ye-rheumatoid, i-myositis, ne- scleroderma .
Ukukhathazeka okukhulu ngeCytoxan kungengozini yokucindezeleka komnkantsha ongangena ingozi yokutheleleka noma ukuphuma kwegazi. Ngaphezu kwalokho, kunengozi encane kodwa eqondile yomdlavuza ohlanganisa isikhumba nesinye. Ezinye iziguli zingase zihlakulele isimo esibuhlungu kakhulu sesisu esibizwa ngokuthi i-interstitial cystitis. Uma isidakamizwa sinikezwa ngomlomo, ukutholakala kwamanzi njalo nokuvuthwa kungasiza ekuvimbeleni le nkinga. I-Cytoxan ivame ukuhlinzekwa ngamagciwane angama-intravenous ngenyanga angase futhi asize.
Isidakamizwa sisifo se-teratogenic (singabangela ukukhubazeka kokubeletha uma kuthathwa ngesikhathi sokukhulelwa) futhi kufanele kugwenywe kwabesifazane abangasebenzisi ukulawulwa kokuzalwa okuphumelelayo noma abangakhulelwa. Okokugcina, kungase kube khona ingozi yokwandisa ukutheleleka okukhulu nge-Cytoxan ukusetshenziswa.
Imuran
I-Imuran i-FDA-evunyelwe isifo samathambo futhi isetshenziselwa ukwelapha i-lupus nezinye izifo ezixhumene nezicubu.
Iphinde ihlobaniswe nobungozi bokucindezeleka komnkantsha we-bone futhi inganciphisa ingozi yezinye kansa. Kukhona ingozi eyengeziwe yokuthola isifo esiyingozi uma uthatha lesi sidakamizwa.
I-Methotrexate
I-Methotrexate i-FDA-evunyelwe isifo samathambo futhi ingaba usizo nakwezinye izifo zesishukela ezifana ne-lupus, myositis, ne-vasculitis.
Nakuba i-methotrexate ingaba nemiphumela emibi efana neminye imithi emibili, kubonakala sengathi inephrofayli engcono yokuphepha. Ngokufanayo ne-Cytoxan, i-teratogenic futhi ayifanele isetshenziswe abesifazane nabalingani babo uma bengasebenzisi ukulawulwa kokuzalwa okuphumelelayo noma kunethuba lokukhulelwa.
Ngaphezu kwalokho, lo muthi uhlotshaniswa nengozi encane ye-lung disease (i-pneumonitis yangaphakathi) engasongela impilo uma isiguli singavumeli umuthi futhi uphathwe. Ngokuvamile, izimpawu zalolu daba zihlanganisa ukuphefumula, ukukhwehlela owomile nomkhuhlane. Njengeminye imithi emibili, kungase kube khona ingozi yokwandisa ukutheleleka okukhulu.