Sulfasalazine (Azulfidine) - Okudingeka Ukwazi

by UCarol Ukulunga; Kubuyekeziwe ngo-Grant Hughes, MD

Izifo-Ukuguqula I-Anti-Rheumatic Drug for Arthritis

I-Sulfasalazine (igama elithi brand Azulfidine) yisidakamizwa esitholakale iminyaka engaba ngu-60, kodwa ukusetshenziswa kwayo kwanda kuphela eminyakeni engamashumi amabili edlule. Kubonakala sengathi ulahlekelwa ukuthandwa okuningi njengoba izidakamizwa ze-biologic zaqala ukuthengiswa ngo-1998 ngenxa ye- rheumatoid arthritis . Kubonakala sengathi ubuyisela iziguli ezingenakubekezelela imettretrexate noma abangakulungele ukwelashwa kwezidakamizwa ze-biologic.

I-Drug Class

I-Sulfasalazine, njengoba ungase usolise egameni layo, ingokwesigaba semithi ebizwa ngokuthi izidakamizwa ze-sulfa. I-Sulfasalazine iqukethe i- salicylate ne-antibiotic ye-sulfa. I-Sulfasalazine iphinda ihlukaniswe njenge- DMARD (isifo esishintsha izidakamizwa zokulwa nesifo sofuba).

Izimpawu zokusetshenziswa kwe-Sulfasalazine

Ngaphandle kokusetshenziswa kwalo njengokwelashwa kwesifo samathambo, i-sulfasalazine nayo inqunyelwe i- arthritis yezingane , i- psoriatic arthritis , i- ankylosing spondylitis , ne-ulcerative colitis.

I-Sulfasalazine isiza ukunciphisa ubuhlungu, ukuvuvukala nokuqina okuhambisana ne-arthritis. Iphumelela kakhulu ekunakekeleni izimpawu ezincane kuya ezilinganisweni. I-Sulfasalazine nayo ingavimbela umonakalo ohlangene futhi unciphise ubungozi bokusebenza okuhlangene. Ngokujwayelekile, iziguli ezithatha isaziso sulfasalazine zithuthuka ekupheleni kwamasonto angu-12.

Ukwazisa Ukudinga Nokutholakala

I-Sulfasalazine iyatholakala njengethebulethi ye-500 mg. Kunconywa ukuthi udla ukudla okunye uphuze ingilazi yamanzi egcwele uma udla i-sulfasalazine.

Ukwelashwa kwe-arthritis ye-rheumatoid ngokuvamile kuqala kancane kancane. Ngeviki lokuqala, iziguli zithatha amaphilisi angu-1 noma amabili e-sulfasalazine ngosuku. Kungase kwandiswe kube amaphilisi amabili kabili ngosuku. I-dose esiphezulu ngamaphilisi angu-6 ngosuku. Amaphilisi ahlanganiswe ngaphakathi angatholakala futhi angasiza ngesisu esithukuthele.

Imiphumela Ehlangene Ehlangene Ehlanganiswa ne-Sulasalazine

I-Sulfasalazine ihlotshaniswa nemiphumela emibi ejwayelekile.

Imiphumela emibi kakhulu yilezi zinhlanhla noma ukuhlukunyezwa kwesisu. Izinkinga zomzimba zibonakala zixazulula ngokuhamba kwesikhathi, ikakhulukazi lapho umuthi unikezwa ngomthamo ophansi ekuqaleni. Imiphumela emibi engavamile ingabandakanya ukuqubuka kwesikhumba, ikhanda lokukhwabanisa, izilonda emlonyeni, ukuchimaza, izinkinga zesibindi, nokuzwela kwelanga.

Ukusabela Okumangalisayo Okumangalisayo

Ukusabela okunzima okukhulu okuhlobene ne-sulfasalazine kuhlanganisa i-anorexia, ikhanda elibi kakhulu, ukucindezeleka okukhulu kwesisu, ukuhlanza, nokubalwa kwesisu. Ukubalwa kwesidoda esiphansi kungabuyekezwa ngokunqamuka kwesidakamizwa. Lezi zindlela ezimbi zithinta ingxenye eyodwa kwezintathu zeziguli eziphathwa nge-sulfasalazine. Ukusabela okubi okungathinti iziguli ezingu-1 eziyisishiyagalolunye ezithatha i-sulfasalazine zibandakanya i-itching, imihlathi, umkhuhlane, i-heinz body anemia, i-hemolytic anemia, kanye ne-cyanosis (i-bleu discoloration).

Ngenkathi ukusabela okubi kakhulu kungacatshangwa ukuthi kuvamile, bavame ukwanda lapho umthamo wansuku zonke we-sulfasalazine ulingana noma udlula ama-4 amagremu. Futhi, kunezinye izimpendulo ezimbi ezihlobene nama-sulfonamide (izidakamizwa ze-sulfa) okumelwe zibhekwe ukuthi zingenzeka nge-sulfasalazine, kuhlanganise nokuphazamiseka kwegazi, ukusabela kwe-hypersensitivity, ukusabela kwesistimu emaphakathi, ukusabela kwenkohliso, kanye nomchamo nokukhishwa kwesikhumba.

Ukungahambisani Nalokho (Obani Akufanele Bathathe Imithi)

I-Sulfasalazine ayiyona indlela efanele yokwelapha iziguli ezinokuvimbela emathunjini noma emanzini, i- porphyria , noma ezigulini ezine-hypersensitivity eyaziwa yi-sulfasalazine, i-sulfonamide, noma i-salicylates.

Ukuxwayiswa nokuqapha

Ukunciphisa ingozi yemiphumela emibi noma ukusabela okubi. kufanele uqaphele lezi zixwayiso nezixwayiso ezilandelayo ngenkathi uthatha isulfasalazine.

Ukuhlolwa kwegazi njalo kufanele kwenziwe ukuze kuqaphe ukubala kwegazi, ukusebenza kwezinso, nesibindi.

Uma uhlela ukukhulelwa, ukhuthazwa ukuba uxoxe nge-sulfasalazine ngokusebenzisa udokotela wakho. Abesifazane abancancisayo akufanele bathathe i-sulfasalazine.

I-Folic acid supplementation ingadingeka uma uphathwa nge-sulfasalazine.

Qaphela ukusebenzisana kwezidakamizwa ne-sulfasalazine uma uthatha i-Coumadin (warfarin), i-cyclosporine noma i-digoxin. Lesi sidakamizwa singandisa ingozi yokulimala kwesibindi kulabo abathatha isoniazid ngesifo sofuba. I-Sulfasalazine ingase futhi ikhulise ingozi yeshukela ephansi yegazi phakathi kweziguli ezithatha imithi yesifo sikashukela.

_Imithombo:

_{I-Sulfasalazine (i-Azulfidine).} _{I-American College of Rheumatology.} _{Mashi 2015.} _{http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Sulfasalazine-Azulfidine}