Izimbangela ze-Progressive Bone Ukuhlaselwa kweCanscer
Izilonda ze-osteolytic (eyaziwa nangokuthi izilonda ze-osteoclastic) ziyindawo yokulimala kwethambo lapho ithambo seliye lanciphisa ngenxa yezibi ezinjengomdlavuza we- myeloma nomdlavuza webele. Izilonda ngokwazo zibonakala njengezimbobo ezincane kwi-X-ray. Abantu ngokuvamile babhekisela kuzo njengokubonakala "kokudliwa ngundu" noma "ukubukwa okuphawulwe".
Ukuthuthukiswa kwezilonda ze-osteolytic kungabangela ubuhlungu, ukucindezeleka komgogodla, futhi ingozi yokwanda kwamathambo.
Ukwelapha ngokuvamile kuhilela ukusebenzisa imithi ukuvimbela ukulahlekelwa kwamathambo okuqhubekayo kanye nokwelashwa kwemisebe ukuze kunciphise ubuhlungu nezinye izimpawu ezihambisanayo.
Izimbangela zezilonda ze-osteolytic
Izilonda ze-osteolytic zenza uma kungenalo ukungalingani kwinqubo yezinto eziphilayo okuthiwa i-bone remodeling. Lapha lapho amangqamuzana endala e-skeleton ephulwa phansi futhi ashintshwe amasha. Phakathi nezinhlobo ezithile zomdlavuza, ezifana ne-myeloma, le nqubo ingahle ilahlekelwe ibhalansi ngokukhiqizwa kwamaseli amasha awakwazi ukuqhubeka nokulahlekelwa kwabantu abadala.
Mayelana ne-myeloma ngokuqondile, kunezizathu eziningana ezenza lokhu kwenzeke. Kukhona uhlobo olulodwa lweseli elibizwa nge-osteoblast elibhekene nokwakha amathambo; enye i-osteoclast ekhishwa izinto eziphula ithambo njengengxenye yenqubo yokulungisa. Lapho i-myeloma ihlasela izicubu zethambo, ivimbela ama-osteoblasts ngenkathi ikhuthaza ama-osteoclasts ukuba aphule amaseli ngisho nakakhulu.
Yimiphi imiphumela emaphaketheni okulimala lapho isakhiwo seseli ngokuvamile kufana nelofah.
Ngaphezu kwe-myelomas, imbangela evame kakhulu yezilonda ze-osteolytic yi-cancers yemetastatic (amagciwane angasakaze ngaphesheya kwesayithi se-tumor original). Lokhu kufaka phakathi umdlavuza we-metastatic of the prostate, thyroid, amaphaphu, izinso, nesifuba.
Izilonda zivame ukutholakala emathanjeni amakhulu, njenge-skull, umgogodla, i-pelvis, i-ribcage, namathambo amakhulu emilenze.
Imiphumela ye-Bone Damage eMyeloma
Izilonda ze-osteolytic bone zingabangela izimpawu eziningi kungakhathaliseki ukuthi umdlavuza uqobo. Phakathi kwazo:
- Ubuhlungu be-bone buvamile futhi bungaba nzima kakhulu, ngokuvamile buhambisana nokulimala kwamagciwane kanye nobuhlungu obubangelwa ukucindezelwa kwethambo
- I-osteoporosis (ukuqhubeka buthaka kwethambo)
- Ukuhlukunyezwa kwegazi okubangelwa amathambo okwebuthakathaka ngumdlavuza
- I-Hypercalcemia ye-malignancy lapho amathambo aphulwa khona ngumdlavuza ukukhulula i-calcium ngokweqile egazini. Ingaholela ekufusweni, ukuhlanza, ubuthakathaka, ukudideka, i-myalgia (ubuhlungu besisu) kanye ne-arthralgia (ubuhlungu obuhlangene). I-Arrhythmia (isilinganiso senhliziyo esingavamile) nayo iyinkinga evamile ukuthi, uma ishiywe ingalashwa, ingaba yingozi.
Ukwelapha izilonda ze-osteolytic
Izilonda ze-osteolytic ziphathwa ngokuhlanganiswa kwemisebe ephansi ne- bisphosphonates , iglasi lesidakamizwa esivame ukusetshenziswa kubantu abane-osteoporosis. Ukuphuza (i-zoledronic acid) yinye imithi esetshenziselwa umdlavuza ukuvimbela ukuwohloka kwezilonda zamathambo.
Ama-bisphosphonates anikezwe ngaphakathi ngaphakathi kwamasonto amane. Imiphumela emibi ihlanganisa umsebenzi wezinso owehlisiwe futhi, ezimweni ezingavamile, i-osteonecrosis yomhlathi (lapho ithambo lomhlathi liqala ukuwohloka).
> Imithombo
- > Bhutani, M .; I-Turkbey, B .; I-Tan, E ,; et al. "Umnkantsha wezinsalela kanye nezifo zamathambo okuqala ezingxenyeni eziningi ze-myeloma kanye nezifo ezihamba phambili: Umuntu ozofundwa ngokusebenzisa isithombe sokusebenza nesimo sokuziphatha." I-Leukemia & Lymphoma . 2015: 57 (5): 1114-21.
- > Rajkumar, S. "I-Myeloma namhlanje: Izincazelo zezifo nokuthuthuka kokwelashwa." I-American Journal of Hematology . 2016. 91 (1): 90-100.
- > Reagan, M .; Liaw, L .; Rosen, C .; futhi al "Ukuzibandakanya okunamandla phakathi kwethambo ne-myeloma eminingi: izindima ezivelayo ze-osteoblast." I-Bone . 2015; 75: 161-9.