Ukucwaninga Okukhulayo Akukaqedi Ukusebenza Kwe-Butyrate
I-butyrate i-asidi yama-fatty chain-short ehlanganiswa emathunjini. Phakathi nenqubo yokugaya ukudla, ama-carbohydrate ahamba ngenqubo yokuvuthwa. Omunye wemikhiqizo yalokhu i-butyrate. I-butyrate enemas iye yahlolwa ukuze isetshenziswe ekuphatheni isifo sofuba esiswini (IBD) , futhi ikakhulukazi isifo sofuba esiswini. Kodwa-ke, ngalesi sikhathi, akukho ukuvumelana mayelana nokuthi, uma, noma nini, ukugcoba inhlama ingasetshenziswa ukuphatha iziguli ezine-ulcerative colitis noma ezinye izinhlobo ze-IBD (njenge-Crohn's disease).
I-butyrate iyishukela lomzimba
Amanye ama-carbohydrate adlula emathunjini ngaphandle kokuba aphule ngokuphelele futhi agaywe. Esikhundleni salokho, bavuthwa yi-bacteria ekoloni (intombazane enkulu), futhi umphumela wukudalwa kwezinto ezihlukahlukene. I-butyrate ingenye yalezi zinzuzo, kodwa ayixhunyiwe umzimba. I-butyrate empeleni isetshenziselwa njengamafutha ngamaseli asendlini yekoloni.
Kungani i-Butyrate ingase ibe nenzuzo ekwelapheni i-Ulcerative Colitis
I-butyrate iboniswe ukuthi inenzuzo kumaseli emgunyeni wamathumbu ngokulwa nokuvuvukala, ukuvimbela amangqamuzana ukuba angaba nomdlavuza, anciphise imiphumela yokucindezeleka okwenziwe nge-oxidative , nokuqinisa izivikelo ze-colonic. I-butyrate enemas iye yaboniswa ukunciphisa ukucindezeleka kwe-oxidative kubantu abadala abanempilo, uma kuqhathaniswa nalabo abathola i-placebo enema ye-saline. Ukucindezeleka oxidative yinqubo lapho amangqamuzana angalimaza khona bese engakwazi ukusebenza kahle.
I-butyrate enemas iye yahlolwa ukuze isetshenziswe ekuphatheni i-ulcerative colitis. Ucwaningo olunye lubonise ukuthi ukusetshenziswa kwama-butyrate (okungukuthi, ukuyisebenzisa ngqo emgodini noma ekugcineni koloni nge-enema) kungasiza ukunciphisa ukuvuvukala emgqonyeni obangelwa ukubola kwesilonda. I-butyrate enemas ingase iphumelele kakhulu ekwelapheni i-ulcerative colitis ezingxenyeni zokugcina zekholoni (okuvame ukubizwa ngokuthi i- distal ulcerative colitis ).
Ikusasa Lokunciphisa Ukuphatha I-IBD
Ngisho noma lezi zifundo zokuqala zibonise isithembiso esithile, i-butyrate ayisetshenziswanga ngokubanzi ekuphatheni i-ulcerative colitis. Izifundo eziningi ezenziwe zenziwe ngamagundane, kodwa hhayi kubantu. Okungenani isifundo esisodwa sasebenzisa i-butyrate yomlomo esikhundleni se-enema, kodwa futhi isifundo sasisemagundeni, futhi izifundo zabantu azikakwenzeka. Abalobi beziningi zezifundo ezitholakala kwi-butyrate kubonisa ukuthi ucwaningo olwengeziwe luyadingeka. I-butyrate iphinde isetshenziselwe ukusetshenziswa kulesi sifo sikaCrohn, nakuba okwamanje akusikho ucwaningo oluningi njengoba kunesifo se-butyrate ne-ulcerative colitis. Nokho, kuye kwabikwa ukuthi abanye abahlinzeki bempilo ehlukile banikeza i-butyrate enemas iziguli zabo ezine-ulcerative colitis esigabeni sokugcina se-colon.
Izwi elivela
I-butyrate iyatholakala ngaphezu kwe-counter, ngakho-ke kubalulekile ukutshela i-gastroenterologist nabanye odokotela ngenkathi uthatha le nkengezo, noma ifomu lephilisi noma njenge-enema noma i-suppository. Ayikho imibiko eminingi yemiphumela emibi kakhulu, kodwa kubalulekile ukuqiniseka ukuthi akukho miphumela emibi engaba yingozi noma ukulimaza ekusebenziseni lokhu, noma okunye, okunye okumele kwenziwe, ukuphatha i-IBD. Kubantu abanesifo esinzima esidlulela ngaphesheya kokuphela kolononi, i-enema noma i-suppository kungenzeka ukuthi ayinayo umthelela omkhulu, ngakho-ke ukuthembela kuyo njengendlela yokwelashwa kungabangela ukulimala uma isetshenziselwa enye imithi ephumelelayo.
Ukwelapha i-IBD kungabandakanya izindlela eziningi zokwelashwa nokuthola into esebenzayo ebalulekile, ukhumbula ukuthi akuwona wonke ukwelashwa okuye wabonisa isithembiso esicwaningweni sokucwaninga kuzosebenza ngempumelelo kubantu abaningi abanesifo.
Imithombo:
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