I-osteoarthritis ivame ukubhekwa ngokuthi i-arthritis yokugqoka nokulala. Kodwa-ke, abacwaningi manje bathola ukuthi akukona ngokuphelele nge-cartilage egqamile. Kunezinye izingxenye ze-anatomy ezihlangene, njenge-bone subchondral, ezidlala indima ebalulekile e-osteoarthritis.
Iyini i-Subchondral Bone?
I-subchondral bone iyisithambo samathambo ngaphansi kwe- cartilage ehlangene.
i-isondlo ibhekisela ku-cartilage, kuyilapho isigaba sesiqephu esincane ngezansi. I-subchondral bone iyisimangalo esishaqisayo emajoyini anesisindo.
Inemithambo eminingi yegazi inikeza izakhi kanye ne-oksijini futhi ithatha ama-waste. Njengoba i-cartilage ingenayo igazi layo, ukuxhumana okufutshane ne-bone vascularrized bone isithwathwa esondla. Lezi zitsha zihlinzeka ngaphezu kwesigamu se-hydration, oxygenation, ne-glucose ye-cartilage. Impilo kanye nokusebenza kwethambo le-subchondral kuzokwenza umehluko empilweni ye-cartilage ephezu kwayo nje.
Kwenzekani ku-Osteoarthritis
Esikhathini se-osteoarthritis, ithambo le-subchondral liba likhulu kunezinye izikhathi. Ubufakazi buphakanyisile ukuthi ukuqina kwenzeka ngaphambi kokuba u-cartilage uqale ukugqoka-isibonakaliso sokuthi i-subchondral bone ithatha indima ekuthuthukiseni i-osteoarthritis. Ucwaningo luye lwabona ukuthi ngaphambi kokuba i-osteoarthritis ikhule kungase kube nokwanda kwezinga lentengo yesitokisi se-subchondral, njengoba kulinganiswa ukukhwabanisa.
Enye inqubo ibangela ukuba ithambo livuselelwe ukuze lidingeke liphule futhi lizilungiselele. Lokhu ngokwemvelo kukhishwa imikhiqizo eminingi ye-metabolism ekuhlinzekeni kwegazi okondla kokubili ithambo ne-cartilage.
I-subchondral bone attrition ukubeka phansi noma ukucindezeleka kwe-articular surface.
Kubonakala ekuqaleni kwe- osteoarthritis ye- knee futhi ubukhona bayo bubikezela ukuthi ukulahleka kwe-cartilage kuzokwakhiwa futhi nokuthi ngabe igumbi lokuguqa lizobe lihlehlisiwe. I-subchondral bone bone i-edema-like lesions kanye ne-subchondral bone attrition zivame ukubonisana ndawonye. Enye inkolelo yokuthi ukugqoka nokudabuka emadolweni kubangelwa ama-micro-fractures okuhlala esimweni sokulungisa njalo. Lo msebenzi uveza ama-enzyme namaprotheni angase abe neminye imiphumela emangcwabeni aseduze.
Abacwaningi bathole nokuthi izicubu ze-subchondral bone zikhiqiza ama- cytokines amaningana afanayo kanye nokukhula (amaprotheni) angabangela ukuvuvukala nokuguquka kwezicubu zomzimba. Okwenzekayo kanye nokuthi yiziphi amakhemikhali okungenzeka abe ophethe kakhulu kudinga ucwaningo olwengeziwe. Kungakhathaliseki ushintsho lwe-subchondral bone yilokho okukhiqiza ukulahleka kwe-cartilage noma ngabe bayayilandela yini umbuzo we-inkukhu noma umama ukuze uthole ucwaningo oluqhubekayo. Yikuphi okuza kuqala? Ingabe enye inqubo yokushayela kokubili? Ingabe ngempela kubangelwa ukugqoka nokudiliza noma kukhona enye imbangela eyinhloko?
Ezinye izimo ze-Subchondral Bone e-Osteoarthritis
- I-Subchondral Cyst : Lokhu kuvame ukubonakala ku-osteoarthritis, isikhwama esigcwele amanzi esivela esivumelwaneni. Kuyinto ejwayelekile kakhulu ekutholeni i-X-ray kodwa ayidingi ukukhipha noma ukwelashwa.
- I-Subchondral Sclerosis : Lokhu kwandisa isibalo se-bone noma ukuqina kwesendlalelo se-subchondral, kubonwe kwi-X-ray ye-osteoarthritis. Ngenye yezimpawu zomlando zesimo.
Imithombo:
> Izakhiwo zezinto ezinokwemvelo nezindlela zomzimba we-subchondral bone e-osteoarthritis. Biorheology. 7/26/2004. I-Radiology Ezocwaningo: October 2000 - Umqulu 35 - Issue 10 - iphe 581-588
I-Rheumatology yanamuhla. Umqulu 13, Inombolo 1. Mashi 2003. http://www.springerlink.com/content/j0d9m9yak10085hc/
UFrank W. Roemer, futhi. al. "Izilonda zomnkantsha we-subchondral zihlotshaniswa kakhulu, futhi zibikezela isikhathi esisodwa ngesikhumba se-subchondral: isifundo se-MOST." I-Osteoarthritis Cartilage 2010 Jan; 18 (1): 47. Ishicilelwe ku-intanethi ngo-2009 Septhemba 10. i: 10.1016 / j.joca.2009.08.018