Iyiphi Inhlobo Ye-Non-Hodgkin Lymphoma i-DLBCL?
Ukusabalalisa i-B-cell lymphoma enkulu yilona uhlobo oluvame kakhulu lwe-non-Hodgkin's lymphoma (NHL) Lymphoma ye- lymphocytes B, noma "ama-B cells. "
Amanqamu Aggressive
Ama-DLBCL ayenomdlavuza wegazi. Ngezinye izikhathi kuthiwa yi-"grade ephakeme" noma "i-intermediate grade" lymphomas ngokungafani ne-"grade low" i-lymphomas ekhula kancane. Lokhu kusho ukuthi bangakhula ngokushesha futhi basakaze ngokushesha kwezinye izingxenye zomzimba.
Ukuziphatha okunesihluku kungase kuzwakale kusabisa kuze kube yilapho ucabangela indlela esiphatha ngayo ukwelapha. Ukwelapha okunjenge-chemotherapy kubulala amaseli akhula ngokushesha. Ngakho-ke kule minyaka lapho sinezokwelapha khona, umuntu uvame ukuba "akhululeke" kusukela ephakeme lymphoma kunokuba aphume ebangeni elingaphansi lymphoma. Abantu abangaba ngu-70% abaphathwa nge-DLBCL bayokwelashwa isifo sabo.
Ukubukeka
Ama-B-amaseli ku-DLBCL amancane, futhi abukeka ahluke kakhulu kunamaseli ajwayelekile B. Uma i-lymph node iphikisiwe, lawa maseli akhona yonke i-lymph node - ekusatshalaliseni okusabalalisa okudala igama layo.
Ubani Owutholayo
Ukusabalalisa i-B-cell lymphoma enkulu kakhulu kuthinta labo abangaphezu kweminyaka engu-50 ubudala, nakuba abantu banoma yimuphi ubudala bangawuthola. Isilinganiso seminyaka esixilongwa ngayo sineminyaka engu-64. Kuvame kakhulu emadodeni kunabesifazane. I-DLBCL, ngokungafani namanye ama-lymphomas, ayibonakali ukugijima emindenini.
Izimpawu
I-DLBCL ivame ukutholakala lapho umuntu ephawula i-lymph node ekhulisiwe, kodwa engeyona ithenda entanyeni noma ekuguleni kwayo.
Abanye abantu bangase babe nezinto ezibizwa ngokuthi yi- B izimpawu ze-lymphoma ezibandakanya imfiva nokugcoba ebusuku.
I-DLBCL ithinta kanjani umzimba?
Abantu abangaba ngu-2/3 kulabo abaye basakaza i-B-cell lymphoma enkulu baye bathuthukisa izifo ngesikhathi sokuxilongwa, beya ezingxenyeni ezihlukene zomzimba. Cishe isigamu seziguli, lesi sifo sithinta izingxenye zomzimba ngaphandle kwama-lymph nodes, njengesisu ( esibizwa ngokuthi i-extranodal disease ).
Umnkantsha wethambo uthinteka ku-10-20% weziguli.
Ukuxilongwa
Ukuxilongwa kwe-lymphoma ngokuvamile kwenziwa nge- lymph node biopsy . Lesi sifo siqinisekiswa njenge-lymphoma, futhi uhlobo lwe-lymphoma luyonqunywa ngokubuka amangqamuzana ayo ngaphansi kwe-microscope nokuhlolwa okukhethekile okubizwa ngokuthi ama-CD markers . Iziguli ezintsha ezitholakale zihlolwe ukuba zithole uchungechunge lwezivivinyo ukuze zithole ukuthi isifo sisithinta kanjani umzimba.
Ukwelapha
Ukwelashwa kuncike esiteji se-lymphoma futhi kungafaka:
I-Chemotherapy ne-monoclonal antibody therapy - Cishe zonke iziguli zithola i-chemotherapy. Umbuso ovame kakhulu u- R-CHOP noma i- CHOP yama-6-8. Izidakamizwa ku-R-CHOP zifaka:
- I-Rituxan (rituximab) - I- Rituxan i-antibody monoclonal . Imizimba yethu yenza ama-antibodies ahlasela amabhaktheriya nama-virus angena emizimbeni yethu. I-rituxan impela i-antibody eyenziwe ngabantu, esikhundleni sokuhlasela amabhaktheriya namagciwane, ukuhlasela amangqamuzana omdlavuza esikhundleni salokho.
- I-Cytoxan (i-cyclophosphamide)
- I-Adriamycin (doxorubicin)
- I-Oncovin (i-vincristine)
- I-Prednisone
Imijikelezo ivame ukuqhutshwa njalo emavikini amathathu ngenani lezingu-8.
Imishanguzo - Ukwelashwa kwezidakamizwa kungafakwa njengengxenye yokwelashwa kulabo abanezigaba zakuqala ze-DLBCL. I-radiation kuleli cala ivame ukuhanjiswa ezindaweni ezihilelekile umdlavuza.
Okuvamile noma Okuqhubekayo DLBCL
Iningi labantu lizophulukiswa nge-chemotherapy enobudlova. Labo abangelapheki noma ukuphindaphinda kwesifo sabo banezinketho zokwelashwa okuqhubekayo, i-antibody therapy kanye nokufakelwa kwe-stem cell.
Isibikezelo
Ukuchazwa kwe-DLBCL kuncike ezintweni eziningi ezihlanganisa iminyaka nobude besifo. Izici zichazwe esigabeni sezici zokubikezela ze-Non-Hodgkin Lymphoma (NHL) .
Ukubhekana nokusekela
Ngisho noma i-DLBCL ine-prognosis enhle - ngokuqondene ne-lymphomas ihamba noma kunjalo - iyesabeka ukuthi itholakale unomdlavuza. Finyelela emndenini nabangani.
Ucwaningo futhi ufunde ngesifo sakho ngokuthola ulwazi olufanele. Cabanga ngokujoyina iqembu lokusekela emphakathini wakho noma hlola imiphakathi yokusekela ye-DLBCL ku-intanethi. Futhi khumbula ukuthi ukwelashwa komdlavuza kuqhubeka ngcono - kokubili kokwelashwa okuthuthukisa izinga lokusinda, futhi kulabo abenza imiphumela embalwa emibi.
Imithombo:
Freedman, A., noJ. Friedberg. Ukwaziswa kwesineke: Ukusabalalisa i-B cell lymphoma enkulu kubantu abadala (Beyond the Basics), UpToDate. Kubuyekezwe 06/30/15. http://www.uptodate.com/contents/diffuse-large-b-cell-lymphoma-in-adults-beyond-the-basics