I-Estrogen Connection
Ingabe bewazi ukuthi ukuba ne-migraine kunganciphisa ingozi yakho yokuthuthukisa umdlavuza webele esikhathini esizayo?
Nakuba umdlavuza we-migraines kanye nebele webele kunemibandela enkulu yezokwelapha ezihlukile, kunesici esisodwa esiyinhloko esithinta noma esixhuma - i-hormone yobulili, i-estrogen.
I-Cancer Isisu ne-Estrogen
Umdlavuza wesibeletho kwenzeka lapho amangqamuzana omdlavuza ashintshiwe ekhula ngokungalawuleki, ngokuvamile emathangeni nasezinkolweni zomzimba wesifuba.
Ukuchayeka okukhulu kwe-estrogen yokuphila kwakho kwandisa ingozi yomdlavuza webele. Ngakho-ke noma yini eyandisa i-estrogen emzimbeni ingakwazi ukwandisa ingozi yomdlavuza webele. Izibonelo zezimiso ezandisa i-estrogen zifaka:
- Inombolo yesikhathi eside sokuphila kwemijikelezo yokuya esikhathini (ukudoba ngaphambi kokuzalwa kweminyaka engu-12, ukuyeka esikhathini sokumisa ngemuva kweminyaka engu-55)
- Ukukhuluphala kwe-postmenopausal, lapho i-adipose noma amanxeba amafutha aguqulwa e-estrogen
- Ukwelashwa kwamaHormone ahlanganisiwe
I-Migraines ne-Estrogen
Isimo se-Migraine sichaphaza besifazane ngokususelwa kumjikelezo wokuya esikhathini, isimo sabo sezinsizwa, nokuthi ngabe bakhulelwe. Lolu shintsho kumvamisa we-migraine nobukhulu bungase luhlotshaniswe namazinga e-estrogen wesifazane eguqukayo.
Isibonelo, imvamisa ye-migraine yanda ngokushesha ngaphambi noma phakathi nesikhathi sokuya esikhathini sesifazane ( ukuya esikhathini ) uma amazinga e-estrogen eyancipha. Ngakolunye uhlangothi, abesifazane abaningi babhekana nokukhululeka kwe-migraines yabo ngesikhathi sokukhulelwa kwesibili nesithathu, isimo se-estrogen esiphezulu.
I-Migraines ne-Cancer Breast: Ukuxhumeka Okumangalisa
Kokubili umdlavuza kanye nomdlavuza wesifu yi-estrogen, ngakho-ke kungase kutholakale isixhumanisi phakathi kwezehlakalo ze-migraine kanye nengozi ephansi yokuthuthukisa umdlavuza webele. Esinye sezifundo zokuqala ukuhlola lobudlelwane bekuyi- Cancer Epidemiology, i-Biomarkers kanye nokuVimbela.
Lolu cwaningo lwathola ukuthi abesifazane abane-self-reported-migraines babe nama-33% anciphisa ingozi yokuthuthukisa i- hormone-receptor enomdlavuza we-ductal ne-lobular carcinoma esimweni se-postmenopausal. Kodwa-ke, lolu cwaningo aluzange lulawulwe ekusetshenzisweni kwe- NSAID , isigaba esivamile semithi esetshenziselwa ukuphatha imishanguzo - futhi izifundo eziningana ziphakanyisile ukuthi ukusetshenziswa kwe-NSAID kungase kube yingozi engozini yomdlavuza webele.
Esinye isifundo ku- Journal of Clinical Oncology sathola nokuthi abesifazane base-postmenopausal abane-self-reported migraines babe nomngciphezi we-cancer wesifuba. Lesi sifundo sithole ingozi engamaphesenti angu-17 engezansi yokuthuthukisa amakhemikhali aphikisayo we-hormone-receptor. Ukwengeza lokhu le nengozi eyanciphiselwe yayizimele ngaphandle kokusetshenziswa kwe-NSAID, kanye nokusetshenziswa kotshwala no-caffeine, okubili okubangelwa yi-migraine .
Ngo-2014, esinye isifundo eCancer Causes and Control sahlola amacala angaphezu kuka-700 omdlavuza webele. Abacwaningi bathola ukuthi uma kuqhathaniswa nabesifazane abangenawo umlando we-migraines, abesifazane abanomlando obanzi we-migraines (iminyaka engaphezu kwengu-30) banengozi engaphansi kwamaphesenti angama-60 okuthuthukisa umdlavuza webele we-estrogen receptor.
Ngaphezu kwalokho, abesifazane ababene-migraine yabo yokuqala ngaphambi kokuba baneminyaka engama-20 babe nesigamu sokwenza umdlavuza webele we-estrogen we-receptor omuhle (kokubili u-ductal and lobular) uma kuqhathaniswa nabangewona ama-migraineurs (abesifazane).
Okokugcina, abesifazane abane- migraine ne-aura babencane kakhulu (cishe ingxenye yesithathu) ukuthuthukisa umdlavuza wesifuba we-estrogen we-receptor (kokubili i-ductal ne-lobular).
Esikhathini se-flip esifundweni se-2013 kuCanscer Causes and Control abangaphezu kuka-7 000 abafudukayo abazange bathole ubuhlobo obalulekile phakathi kwamagraines kanye nobungozi bomdlavuza webele.
Yiqiniso, zonke lezi zifundo zinokulinganiselwa, futhi uma kuthathwa eceleni kungase kuchaze imiphumela yabo ehlukile. Isithombe esikhulu lapha ukuthi lesi sihloko nobuhlobo obuthakazelisayo kufanele buhlolwe ngokuseduze.
Okubalulekile
Khumbula, isixhumanisi sisho ubuhlobo obunokwenzeka noma ubudlelwane.
Akusho ukuthi isimo esisodwa sezokwelapha sibangele noma sivimbela omunye. Kudingeka izifundo eziqhubekayo eziqhubekayo ukuhlola ubudlelwano obuyinkimbinkimbi phakathi komdlavuza webele ne-migraines.
Lokho Kusho Ngami?
Qhubeka uhlale usebenza ngokunakekelwa kwezempilo. Xoxani ngezifo zakho ezingozini zomdlavuza webele. Buyekeza ukuthi indlela yokuphila enempilo, njengokulahlekelwa kwesisindo, inganciphisa ukuhlupheka kwakho kwe-migraine ngaphezu kwengozi yomdlavuza webele.
Imithombo:
I-Dumitrescu R, i-Cotarla I. Ukuqonda ingozi yomdlavuza webele: sihlala kuphi ngo-2005? J Cell Mol Med 2005; 9: 208-21
UHarris RE, uChlebowski RT, uJackson RD, et al. Umdlavuza wesibeletho kanye nezidakamizwa ezingezona ukuvuvukala ezingekho emthethweni: imiphumela engaba yi-Women's Health Initiative. I-Cancer Res 2003; 63: 6096-101.
Li CI, Mathes RW, Bluhm EC, Caan B, Cavanagh MF, Chlebowski RT. Umlando we-Migraine kanye nengozi yomdlavuza wesifuba phakathi kwabesifazane be-postmenopausal. J Clin Oncol . 2010 Feb 20; 28 (6): 1005-10.
Mathes RW et al. I-Migraine kubesifazane be-postmenopausal kanye nengozi yomdlavuza webele we-invasive. I-Cancer Epidemiol Biomarkers Ngaphambi . 2008 17: 3116-3122.
Ubusika be-AC, i-Rexrode KM, i-Lee IM, i-Buring JE, i-Tamimi RM, i-Kurth T. Migraine kanye nengozi elandelayo yesifo somdlavuza wesifuba: isifundo seqembu elizoba khona. I-Caus Causes Control . 2013 Jan; 24 (1): 81-9.