Izakhi zakho zofuzo zibalulekile, kodwa kunjalo nezinye izici
Akucaci ukuthi yini ebangela isifo se-celiac . Eqinisweni, iningi labacwaningi bakholelwa ukuthi kunezici eziningi ezibandakanyekayo, konke okungase kudingeke ukuthi isimo sithuthuke.
Izakhi zakho zofuzo zidlala indima eqinile-uma ungenayo eyodwa yezakhi zofuzo ezimbili ezixhunywe nesifo se-celiac, izinkinga zakho zokuthuthukisa isimo ziphansi kakhulu (nakuba kungenjalo).
Kodwa-ke, inani elincani labantu (cishe 40%) empeleni lithwala eyodwa noma zombili zalezi zakhi zofuzo, ngakho-ke izakhi zofuzo akuyona kuphela into edlalwa lapha.
Ukuze uthuthukise isifo se-celiac, kumelwe udla i- gluten . Uma unesifo se-celiac, i-gluten igqugquzela isimiso sakho somzimba omzimba ukulimaza intumbu yakho encane. Noma kunjalo, i-gluten iyinto evamile kakhulu ekudleni kwesitayela saseNtshonalanga (abantu abaningi badla i-gluten-futhi njalo kaningi-izikhathi eziningana ngosuku ngalunye), kanti namanje abantu abangaba ngu-1 kuphela bahlakulela isifo se-celiac.
Okokugcina, ukuze uhlakulele isifo se-celiac, izici endaweni yakho kufanele zisize ukubangela. Yilezi "zici" ezingacacile; Abanye abantu bangadla i-gluten nsuku zonke amashumi eminyaka bengenayo inkinga bese bekhula izimpawu zesifo se-celiac ngokuzumayo, kanti ezinye izingane ezincane zikhombisa izimpawu eziqhamuka ngokushesha lapho kutholakala okusanhlamvu okuqukethe i-gluten.
Ucwaningo olulodwa lubonisa ukuthi igciwane elivamile lingabasiza ekuthuthukiseni isifo se-celiac.
Kodwa-ke, lolu cwaningo luyisandulela futhi kwenziwe ucwaningo olungaphezulu ukuze kukhishwe imiphumela yangempela.
"Hamba" Kungasiza Ukwenza Izifo ZamaCeliac
Abanye abacwaningi baye bacabanga ukuthi isifo se-celiac sidinga "ukuqhuma," okungenzeka kuthathe uhlobo lwezempilo noma ukucindezeleka okukhulu ngokomzwelo; isibonelo, abesifazane abaningi baqala ukuzwa izimpawu ze-celiac emva kokukhulelwa nokuzalwa, kanti abanye abantu bathola izimpawu zabo baqala ukulandela ukugula okubonakala kungahlangani, noma ngisho nokulandela isikhathi esicindezelayo empilweni yabo .
Kodwa-ke, le nkulumo "ye-trigger" ayihlali ingavunyelwe.
Abanye ososayensi bacabanga ukuthi okuqukethwe kwe-gluten ekudleni kwethu-okukhule kakhulu eminyakeni engaphezu kwengu-40 edlule, kokubili njengoba sidla imikhiqizo eningi yokusanhlamvu futhi njengokolweni uqobo lwayo lunezigaba eziphakeme kakhulu ze-gluten-kungabangela ukuba kube neminye imizwa yesifo se-celiac. Kunobufakazi obunjalo bokuthi le nkulumo isetshenziswe, ngoba ucwaningo oluthile lwathola ukuthi izifo zesifo se-celiac seziphindwe kabili njalo eminyakeni engu-15 kusukela ngo-1974.
Kanti abanye bebhekene nesifo se-celiac ezingeni lemangqamuzana. Ucwaningo lwamuva lufake izibonakaliso ezimbili zamakhemikhali-i-interleukin 15 ne-retinoic acid, okuvela ku-vitamin A-njengabaqalayo abangabangela ukuphendula komzimba ku-gluten. Abacwaningi babheka abantu abane-diagnosis ye-celiac, futhi bathola ukuthi banezinga eliphezulu le-interleukin 15 emathunjini abo. Lapho behoxisa amazinga aphezulu alowo makhemikhali emagundwini, amagundane aveza izibonakaliso zakuqala zesifo se-celiac. I-retinoic acid yandisa izimpawu kanye nomonakalo.
Lapho abacwaningi bevimbela i-interleukin engu-15, noma kunjalo, amagundane abuyele ejwayelekile futhi akwazi ukubekezelela i-gluten futhi. Lokhu kwaholela ososayensi ukuba bacabange ukuthi amazinga aphakeme e-interleukin 15 emathunjini akho angabangela isifo se-celiac.
(Yiqiniso, akukacaci ukuthi yini engabangela amazinga aphezulu e-interleukin ukuthuthukisa emathunjini akho.) Noma kunjalo, uma kunjalo, imithi evimbela i-interleukin 15 (esevele isesimweni esivivinini se-rheumatoid arthritis) ingase isize futhi aphathe isifo se-celiac.
Ukuxhumanisa Okungenzeka Kuphakathi Kwe-Celiac ne-Reovirus?
Ososayensi baye baqaphela ukuxhumana okukhona phakathi kwesifo se-celiac kanye nohlobo lwegciwane elibizwa ngokuthi i-reovirus. I-Reovirus ihlasela abantu abaningi, ngokuvamile lapho beyizinsana, kodwa kubangela izimpawu ezimbalwa noma ezingekho. Isifundo, eshicilelwe encwadini yeSayensi , esetshenziselwa amagundane okwakhiwa ngokukhethekile ukuba abe nesifo se-celiac.
Abacwaningi bathola izimpendulo ezinamandla zokuzivikela ezimpilweni kulawo makhambi lapho behlaselwe igciwane bese bondla i-gluten.
Abacwaningi baphinde bahlaziya abantu abaye bahlola ukuthi bane-celiac isifo, bebhekene ngqo nama-antibodies kule virus ethile. Bathole amazinga aphezulu kakhulu e-antibodies e-reovirus kubantu abane-celiac-amabili kuya izikhathi ezinhlanu eziphakeme kunabantu abangenawo isimo.
Lolu cwaningo alusondeli ekuboniseni i-reoviruses imbangela-noma ngisho nesifo se-trigger-celiac. Abacwaningi bazodinga ukuqhuba izifundo ezengeziwe ukuze babone ukuthi ngabe isixhumanisi sinamathela yini. Kodwa-ke, uma ama-reoviruses enza isandla ekuthuthukiseni isifo se-celiac, kungenzeka ukuthi umuthi wokugoma ungasiza ekuvikeleni abantu abanezinhlobo zomzimba.
Isizathu Sezifo Ezibucayi Asikacaci, Naphezu kocwaningo
Ngakho ukuhlanganisa, isifo se-celiac sibangelwa yi: ukuba nama-geni afanelekile, ukudla i-gluten, futhi mhlawumbe ngenye indlela ye-trigger.
Enye inkolelo engalungile yinto ethandwa kakhulu ekusola ukukhuphuka kwesifo se-celiac nokungahloniphi kwe-gluten ukuzwela kokolweni okwenziwe ngezakhi zofuzo. Njengoba okusanhlamvu okwenziwe ngokwezakhi zofuzo akuyona emakethe noma kuphi, ngeke kubangele ukwanda .
Kodwa-ke, isayensi yezokwelapha isazi kangako mayelana nanoma yikuphi okubangela ukuthi kwenzeke, yize lezo zibonakala ziyisihluthulelo sokuba abanye abantu abanegciwane "elungile" bathuthukise isifo se-celiac kanti abanye bengenzi. Empeleni, abacwaningi sebeqale ukuhlola amathuba ahlukahlukene. Kungenzeka futhi ukuthi kunezinye izakhi zofuzo ezihilelekile ezingakabonakali.
Kodwa-ke, akungabazeki ukuthi ukucacisa imbangela yesifo se-celiac kungasiza ekuthuthukiseni ukwelashwa kwemithi yokwelapha. U-Alessio Fasano, MD, umqondisi we-University of Maryland kaMucosal Biology Research Center kanye neCoric for Celiac Research, uthi ucwaningo mayelana nezinkinga ezikhona ezingokwemvelo zesifo se-celiac kubaluleke kakhulu-ukukhomba izimbangela zesifo se-celiac kungasiza ekudaleni ukwelashwa kwe-celiac noma ngisho ukuvimbela isimo ngokuphelele.
Imithombo:
Bouziat R et al. > I-Reovirus Infection Ishukumisa Izimpendulo Zokuvuvukala ku-Antigens Yokudla NeNtuthuko Yezifo Ezibucayi. Isayensi . 2017 Apr 7; 356 (6333): 44-50.
I-Catassi C. et al. Umlando wemvelo wesifo se-celiac isifo se-USA esilandelayo kusukela ngo-1974. Okthoba 2010, iphe. 530-8.
Isikhungo se-University of Chicago Celiac Disease. Izimpawu.
I-University of Chicago News. Izifundo zabantu kanye negundane zigxila ekubhekiseni imbangela yesifo se-celiac.
I-University of Maryland School of Medicine News. I-University of Maryland Centre for Research Celiac Ithola Isilinganiso Sezifo Ezigulayo Kukhula.