I-autoantibodies ngamaprotheni akhiqizwa amasosha omzimba wakho. Cishe uyazi ukuthi amasosha omzimba wakho aklanyelwe ukulwa nezinsongo ezifana namagciwane nama-bacterium enza indlela yawo emzimbeni wakho. Kodwa i-autoantibody ijika ukuhlaselwa kwayo into engalungile: Esikhundleni sokuhlasela abahlaseli bangaphandle, ama-autoantibodies ahlasela ngokungalungile izingxenye zomzimba wakho.
Uma benza lokhu, i-autoantibodies ibangela ukuvuvukala nokulimaza kunoma yisiphi isimiso somzimba esenzekayo sokuhlasela. Lo monakalo uholela kulokho esikubiza ngokuthi " isifo se-autoimmune " -ngokuthi, "auto" kusho "uqobo." I-autoantibodies ivela ngaphambi kokuba izimpawu zesifo sangempela ziveze.
Kungani umzimba wakho wenza ama-Autoantibodies?
Akucacile. I-Genetics cishe idlala indima kule nqubo, njengoba kwenza izinto eziphilayo. Kodwa abacwaningi abazange bacacise ukuthi kungani abanye abantu abanesifo sofuzo esifanayo kanye / noma izimbangela ezifanayo zemvelo eziqala ukwenza ama-autoantibodies bese beqhubeka nokuthuthukisa isifo se-autoimmune, kanti abanye abenzi. Esifweni se-celiac , isibonelo, umzimba wakho uphendula ekungeneni kweprotheyini ye -gluten ekudleni okudlayo ngokudala i-autoantibodies bese uqhubeka nokuhlasela ubhedu bamathumbu akho amancane.
Manje, iningi labantu abanesifo se-celiac sithatha isisodwa sezakhi zofuzo ezibabeka esimweni.
Kodwa lezi okuthiwa yi- celiac izifo zofuzo zivame kakhulu, futhi ingxenyana encane yalabo abanezici zofuzo eziqala ukwenza ama-autoantibodies futhi baqhubeke nokuthuthukisa isifo se-celiac. Ngakho-ke, kusobala ukuthi kukhona okunye okudlalayo okubangela umzimba wakho ukuba uqale ukwenza ama-autoantibodies. Ucwaningo luyaqhubeka ukuthola ukuthi yini "into" engaba yiyo.
Yini Okunye Okufanele Ngiyizi Nge-Autoantibodies?
Amanye ama-autoantibodies ahlasela isici esithile-isibonelo, ama-autoantibodies ekuhlaselweni kwesifo se-celiac emathunjini amancane, ama-autoantibodies ngokuzibulala ngesifo se-thyroid esihlalweni se-thyroid, kanye ne-autoantibodies kuhlobo lwesi-2 lwesifo sikashukela ehlasela amaseli akhiqiza i-insulini kuma-pancreas.
Lezi zi-autoantibodies eziqondene nomzimba ngokuvamile ziholela ezimpawu eziqondile ezizosiza udokotela wakho ukuba ahlolwe kahle. Isibonelo, kunezimpawu ezingamakhulu eziningana zesifo se-celiac , kodwa izimpawu ezivame kakhulu, ezibandakanya izinkinga zokugaya nesifo segazi, zinganikeza inkomba yokusiza ekuxilongweni.
Amanye ama-autoantibodies yilokho okubizwa ngokuthi "systemic," okusho ukuthi bahlasela ezindaweni ezahlukene kuwo wonke umzimba wakho. Lezi zingase zenze izimpawu eziningi ezijwayelekile, ezifana nobuhlungu obuhlanganyelwe kanye nezinhlayiya, okwenza isimo esiyinkimbinkimbi kunzima kakhulu ukuyihlolisisa.
Isibonelo, kungase kube nzima ukutshela umehluko phakathi kwesifo se-autoimmune lupus kanye ne-fibromyalgia, odokotela abakholelwa ukuthi akuyona isimo esizimele. Ukuze usize ukwenze ukuxilongwa, odokotela bangalawula ukuhlolwa kwegazi befuna ama-autoantibodies okuthiwa ama-antibodies anti-nuclear, noma i-ANA. Lawa angama-autoantibodies ahlasela izingxenye ze-nuclei yamaseli wakho, futhi cishe wonke umuntu onenkinga ye-lupus uzovivinya amahle, uma kuqhathaniswa nephesenti elincane lalabo abane-fibromyalgia.
Imithombo:
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Dönmez S et al. Izifo zesifo se-rheumatic ezihambisana nezifo ezihambisana neziguli ezithinta izifo ze-fibromyalgia kanye nomthelela wazo ekukhathazeni, ukucindezeleka nokufingqa: isifundo sokuqhathaniswa. I-Rheumatology yezokwelapha kanye nokuhlola . 2012 Nov-Dec; 30 (6 Isamba 74): 65-9.
I-Fujii T. Imisebenzi eqondile neyodwa engaqondakali ye-autoantibodies ngezifo zesimiso esizimele. I-Allergology International . 2014 Dec; 63 (4): 515-22.
I-Hu ZD et al. I-autoantibodies kwisifo sokuzimela esandulela umtholampilo. Clinica Chimica Acta: I-International Journal of Clinical Chemistry . 2014 Nov 1; 437: 14-8.