I-Gonadotropin Ekhulula Ama-hormone Agonists (GnRH)
Umbuzo: Yini i-Gonadotropin ekhulula ama-hormone Agonists (GnRH)?
Impendulo: I- Gonadotropin ekhulula i-hormone agonists (GnRH) uhlobo lomuthi ovimbela ukuvuthwa ngokuvimba ukukhiqizwa kwe-estrogen ne-progesterone.
I-Gonadatropin-Ukukhulula i-hormone iyinhlangano ye-hormone engokwemvelo emzimbeni. Ikhishwa yi-hypothalamus futhi ilawula ukukhululwa kwe-follicle evuselela i-hormone (i-FSH) ne-luteinizing hormone (LH) kusuka emthonjeni we-pituitary.
La mahomoni ama-FSH ne-LH bese ekhuthaza ukukhiqizwa kwe-estrogen ne-progesterone emaqanda. Yilobu buhlobo obubizwa ngokuthi i-hypothalamic pituitary ovarian axis elawula umjikelezo wakho wokuya esikhathini.
Ukuze le nsiza isebenze kahle futhi ibangele ukuvotela i-GnRH kufanele ikhishwe ngendlela ephathekayo. Uma lokhu kusebenza kusebenza ngokufanele uzoba nezikhathi ezivamile uma ungazange ukhulelwe uma uvula.
Iklasi lemithi eyaziwa ngokuthi i-GnRH agonists ixhaphaza lesi sidingo sokuvalwa kwe-GnRH ye-pulsatile. Imithi iholela ekugqugquzeleni okuqhubekayo kwe-pituitary gland. Ekuqaleni kungase kube nokunyuka okuncane kwe-FSH ne-LH ukukhululwa kodwa ukuhlushwa okungenayo i-GnRH okungewona okwenza ukuthi i-pituitary gland iqede ukhiqiza i-FSH ne-LH, ekugcineni iguqula ukukhiqizwa kwe-hormone ku-ovary.
Ama-agonists amathathu aseGnRH avame ukusetshenziswa emtholampilo yilezi:
Lupron- leuprolide
I-Zoladex- goserelin
I-Synarel- nafarelin
I-Leuprolide ne-goserelin zilawulwa umjovo ngama-dose amaviki amane noma amaviki angu-12 ngenkathi i-nafarelin ilawulwa yi-nasal spray 1-2 izikhathi nsuku zonke. Abaningi besifazane bayothola ukuxoshwa kwama-ovari abo ngamaviki amane kanti cishe bonke abesifazane bazoba ngemva kwamaviki ayisishiyagalombili okwelashwa.
Ngenxa yokuthi i-GnRH igonists ukuvala okwesikhashana ama-ovaries ukukhiqizwa kwe-estrogen kanye ne-progesterone leli klasi lemithi lisetshenziselwa ukuphatha izimo ezithile kwabesifazane abanesifo se-estrogen ne-progesterone. Lokhu kufaka:
I-Endometriosis
Ama-Froid e-Uterine
Ukuphathwa kokuphuma esikhathini esinzima kokuya esikhathini
Isifo sofuba se-Premenstrual syndrome / i-Premenstrual dysphoria disorder
Ukwelashwa kokungahambi kahle
Kukhona nobufakazi obufakazela ukuthi abakwa-GnRH abagogodla bangasiza futhi ukugcina abesifazane base-ovarian functionin abasebenzisa i-chemotherapy yomdlavuza webele.
Le mithi iyindlela yokwelashwa ephumelela kakhulu. Ngeshwa banemiphumela emibi ebalulekile. Ngenxa yokuthi zivimbela ama-ovaries ukukhiqizwa kwama-hormone imiphumela emibi ye-agnists ye-GnRH ilingisa izimpawu zokuya esikhathini. Lemiphumela emibi ihlanganisa:
Ukukhanya okushisayo- okuvame ukubikwa ngo-80% wabesifazane
Ukomisa kwamagagasi
Kunciphise libido
Izinwele
Ukukhathala
Ukuphazamiseka kwemizwelo
Ukwehlisa isisindo samaminerali
Ngokusobala izimpawu ze-menopausal azijabulisi kodwa okuphathelene nomphumela wecala ukulahlekelwa kwamathambo omzimba. Ngokuvamile ukulahlekelwa kwethambo kuguqulwa ngemuva kokuba ukwelashwa kuyeke kodwa ngesilinganiso esincane sabesifazane lokhu kulahlekelwa kwethambo angeke kutholakale ngokugcwele.
Ukuvimbela ukulahlekelwa kwethambo elihlobene ne-GnRH ukwelashwa udokotela wakho cishe uzobeka i-progestin noma inhlanganisela ye-estrogen ne-progestin.
Lokhu kwaziwa ngokuthi ukwengeza ukwelapha emuva futhi kuboniswe ukuthi kuphumelele ekuvimbeleni ukulahlekelwa kwethambo okuhlobene nokusetshenziswa okude kwe-GnRH agonists. Kungasiza futhi ukunciphisa ubukhulu bokushisa okushisayo.
Kubuyekezwe ngu-Andrea Chisholm MD
I-Magnon N.Gonadotropin ekhulula ama-hormone agonists: Ukwandisa i-vistas; I-Indian Journal Endocrinology Metabolism. 2011 ngo-Okthoba-Dec; 15 (4): 261-267