Lezi Antibodies zingase Zithonye, kodwa Akusho Ukumisa Hormone Indawo esikhundleni
Ama-antibodies ngamaprotheni akhiqizwa umzimba wakho ophendula noma ozama ukubhubhisa ama-antigens, okuyizinto, ezifana namagciwane nama-bacteria, ukuthi umzimba uveza ukuthi ungaphandle.
Kwezinye izimo, umzimba wakho uveza ngokungalungile izigcawu zakho, izicubu, nezitho zangaphandle. Lolu hlobo lokuphendula luyisici se-autoimmune disease s , futhi lawa ma-antibodies, aqala ukuhlasela okungalungile emzimbeni womuntu, abizwa ngokuthi ama-autoimmune antibodies.
Iqembu elilodwa lama-antibodies okuzenzakalelayo yi- antibiotic ye-peroxidase (TPO) ye-thyroid , futhi ukutholakala kwabo ("positivity") kusikisela ukuba khona kwesifo se-autoimmune, ngokuvamile i-Hashimoto's thyroiditis.
Ukuqonda uHashimoto's Thyroiditis
Ku-Hashimoto's thyroiditis, amasosha omzimba we-TPO ahlasela isifo sakho se-thyroid.
Ngokuhamba kwesikhathi, ama-antibodies e-TPO abangela ukuvuvukala futhi ekugcineni angabhubhisa konke noma ingxenye yengane yakho ye-thyroid. Njengoba i-thyroid ihluleka kakhulu ukukhiqiza i-hormone ye-thyroid, kancane kancane ungaba i-hypothyroid. Ama-antibodies kaHashimoto nawo angabangela i-thyroid yakho ukuba ihlanganise ama-nodules, noma ikhuliswe, eyaziwa ngokuthi i-goiter.
Noma kunjalo, kungathatha isikhathi sengozi esonakalisayo kwi-thyroid yakho ukuze kuboniswe izinga lakho lokuhlola le-hormone le-hormone (TSH) yakho. Akuyona into engavamile, empeleni, ukuba ne-TPO antibodies enhle izinyanga noma iminyaka ngaphambi kokuba izinga lakho le-TSH lifike endaweni lapho uthola khona ukuthi une-hypothyroidism.
Kubalulekile ukuphawula ukuthi abanye abantu abangeke bathuthuke ekubeni yi-hypothyroid, naphezu kokuba nama-antibodies ama-TPO enhle.
Ama-Antibodies we-TPO anembile, i-TSH ejwayelekile: Ingabe i-Treatment iqinisekisiwe?
Ngokuvamile, uma umphumela wakho wokuhlola we-TSH uvamile (phakathi kwamayunithi angu-0.4 no-4.5 milli-international ngekreyi, noma i-MU / L), ukwelashwa (ene-hormone ye-hormone esikhundleni somuthi) akuqinisekisiwe, ngisho noma izifo zamagciwane ze-TPO zihle.
Kodwa-ke, uma i-TSH yakho iphakanyiswa kahle (ake sithi ukusunduza cishe ku-6.0mU / L) kanye ne-thyroxine yakho (i-hormone ye-thy4xine) evamile, "ukuzethemba" kwama-antibodies we-TPO kungangena udokotela wakho ekutholeni ukwelashwa kwe-hormone yegciwane. Lokhu kungenxa yokuthi ukwelashwa okusheshayo kungavimbela ukuqhubeka kwalokhu okuthiwa i-subclinical hypothyroidism ibe yi-overt hypothyroidism.
Udokotela wakho angase aphinde aphikiswe ukuze aphathe i-subclinical hypothyroidism uma unempawu ezifana nokukhathala, ukuqotshwa, noma ukucindezeleka, noma unezinye izifo ezizimele, isibonelo, isifo se-celiac.
Ubudala, futhi, buzobamba iqhaza kwisinqumo sikadokotela wakho. Ngokuvamile, kunomkhawulo ophakeme wokuqala imithi ye-hormone esikhundleni sabantu abadala asebekhulile, ngoba i-TSH yabo yokuqala isemkhawulweni ophezulu ojwayelekile.
Izwi elivela
Okubalulekile lapha ukuthi ama-antibodies aphilile we-thyroid aveza inqubo yokuzimela; Kodwa-ke, bayisigaxa sephayiphi ye-thyroid futhi ngokuvamile akusho ukuthi ngabe udinga ukwelashwa kwe-hormone ye-orroid yini noma cha. Kunalokho, bangathonya wena nesinqumo sikadokotela wakho, phakathi kwezinye izinto ezifana nobudala bakho, umlando womndeni, nezimpawu.
Ngokuphelele kungcono ukukhuluma nodokotela wakho mayelana nemiphumela yakho yamabhalane eyingqayizivele nezimpawu.
Ngale ndlela ungaqinisekisa ukuthi uthuthukisa impilo yakho yezempilo kanye neyonke.
> Imithombo:
> Braverman, L, Cooper D. Werner & Ingbar's The Thyroid, 10th Edition. I-WLL / Wolters Kluwer; 2012.
> Davies TF. I-Pathogenesis ye-Hashimoto's thyroiditis (engapheli i-autoimmune thyroiditis). I-Ross DS, ed. Kusesikhathini. Waltham, MA: UpToDate Inc.
> Garber, J, Cobin, R, Gharib, H, et. al. "Iziqondiso Zomtholampilo Zokusebenza Nge-Hypothyroidism Kubantu Abadala: I-Cosponsored yi-American Association of Endocrinologists Clinic kanye ne-American Thyroid Association." I-Endocrine Practice. I-Vol 18 No. 6 Novemba / Disemba 2012.
> Jonklaas J et al. Imihlahlandlela yokwelashwa kwe-Hypothyroidism: Yilungiselelwe i-American Thyroid Association Task Force kwi-Thyroid Hormone Replacement. I-Thyroid . 2014 Dec 1; 24 (12): 1670-1751.
> Kent, u-Athol. "Izithiyo Zokuvimbela I-Thyroid Ezihlobene Nokuqothulwa Kwangaphandle Nokuzalwa Kwangaphambi Kokuzalwa." Ukubuyekezwa ku-Obstetrics and Gynecology 4.3-4 (2011): 128-129. 2011.