I-Angiotensin yokuguqula i-enzyme (ACE) inhibitors ingumuthi wezomlomo ongaphansi kwengcindezi yegazi. Ama-inhibitors e-ACE asetshenziselwa ukwelapha umfutho wegazi ophezulu (umfutho wegazi ophezulu), isifo se-artery coronary kanye nokuhluleka kwenhliziyo, nokusiza ukulawula ukuqhubeka kwesifo sikashukela nesifo sezinso.
Sibutsetelo
Lezi zinqubo zezifo zivame ukuhamba ngesandla; Umfutho wegazi ophezulu uvame kakhulu kubantu abanesifo sikashukela.
Umfutho wegazi ophakeme uphinde ubangele ekuthuthukiseni i-nephropathy yesifo sikashukela (isifo sezinso).
Ngaphezu kwalokho, labo abanesifo sikashukela bavame ukuba nemiphumela embi kakhulu (izibhedlela ezihlala isikhathi eside, izikhathi zokuphumula ezinde futhi izingozi eziphezulu zokutheleleka) kusuka ezinkingeni ezinkulu zenhliziyo. Ngakho-ke, abahlinzeki bezempilo bayaphatha umfutho wegazi ophezulu ekhonsathini nesifo sikashukela .
Ngesikhathi ama-inhibitors e-ACE engaphili ngokuqondile ushukela wegazi, angafaka isandla ekulawuleni ushukela wegazi ngokukhulisa ukuzwela komzimba ku-insulin. I-insulin isisiza umzimba ukuthi usebenzise i-glucose (ushukela) bese uyisusa egazini bese ungena emangqamuzaneni, lapho usebenza njengomthombo wamandla.
Ama-inhibitors amaningi e-ACE atholakala e-United States, kuhlanganise ne-Capoten (i-captopril), i-Prinivil ne-Zestril (i-lisinopril), iVasotec (i-enalapril), uLotensin (benazepril), i-Altace (ramipril), i- Accupril (i-quinapril), i-Monopril (i-fosinopril), i-Mavik ( trandolapril), Aceon (perindopril) no-Univasc (moexipril).
Indlela Abasebenza ngayo
I-ACE inhibitors ingcindezi ephansi yegazi ngokuvimbela umzimba ukuthi ungakhiqizi i-hormone angiotensin II. I-Angiotensin II ibangela i-vasoconstriction (ukunciphisa kwemithambo yegazi) nokugcinwa kwamanzi, okwenza kube nomfutho wegazi ophezulu. Ngokunciphisa ukucindezelwa kwegazi nokugcinwa kwamanzi, i-ACE inhibitors isiza ukulawula ukwehluleka kwenhliziyo.
Ama-inhibitors e-ACE angavimbela futhi alawule i-nephropathy yesifo sikashukela (isifo sezinso) futhi asize ukulawula i-retinopathy yesifo sikashukela (izinkinga zeso). Ama-inhibitors e-ACE awaphuzi ukushaya kwenhliziyo noma ushukela wegazi ophansi.
Umlando Wokusetshenziswa
Ama-inhibitors e-ACE abe avunyelwe i-FDA ekwelapheni umfutho wegazi ophezulu kusukela ngo-1981. Ngokuhamba kwesikhathi, ukusetshenziswa kwe-ACE inhibitor kuye kwandise ngokuphawulekayo ukuphatha isifo senhliziyo nesimo nezimo ezihlobene.
Ubani okufanele agweme
Abantu abanomfutho wegazi ophansi kakhulu (hypotension), noma ababenokugula noma ukukhwehlela okuhlobene ne-ACE inhibitors, akufanele basebenzise i-ACE inhibitors. Akufanele nalabo abanesifo somzimba we-renal stenosis, abesifazane abakhulelwe nabesifazane abazama ukukhulelwa.
Abantu abanomonakalo omkhulu wezinso badinga ukulungiswa kokulungiswa kwe-ACE inhibitors.
Imiphumela emibi kanye nezingozi
Yonke imithi yegazi ibeka ingozi ye-hypotension, enezibonakaliso ezihlanganisa ikhanda elincane, isizungu, isicashu, ukujuluka nokulahlekelwa ukwazi.
Ngokuvamile, i-ACE inhibitors ingabangela ushukela wegazi ophansi (i-hypoglycemia). Lokhu kwenzeka kubantu abanesifo sikashukela abanamazinga ashukela egazi okwehlukile okulawulwa kahle ngokudla kanye neminye imishanguzo ye-antidiabetic.
I-ACE inhibitors ingabangela ukukhwehlela kwabanye abantu. Uma lokhu kwenzeka, kufanele bakhulume ngalokhu nabahlinzeki babo bezempilo, abangase babekele imithi ehlukahlukene yegazi.
Okunye ukusetshenziswa 'kwe-Off-Label'
I-ACE inhibitors ingasiza ekuvimbeleni ukuqala kwe- type 2 yesifo sikashukela . Ngaphezu kwalokho, i-ACE inhibitors ingasiza ekulawuleni izilinganiso ezingavamile zenhliziyo, ikakhulu uma isetshenziswe ngemuva kokuhlaselwa yinhliziyo.
Ama-inhibitors e-ACE asetshenziselwa ilebula ekuphatheni izifo ezinjenge-arthritis ye-rheumatoid, i-migraines, isenzakalo sikaRaynaud ne-Bartter syndrome.
Amathiphu wezeMpilo
I-Angiotensin receptor blockers (i-ARB) ifana ne-ACE inhibitors. Abantu abaphikisana ne-ACE inhibitors noma abahlakulela ukukhwehlela okuhlobene ne-ACE inhibitors bangashintsha kuma-ARB ngomphumela omuhle. Abantu abanesifo sikashukela kufanele bahlale betshela abahlinzeki babo bezempilo ngokuphathelene neminye imithi yokugqoka kanye nokunye okuningi, kanye nanoma yimaphi ama-herbs kanye nama-supplements asetshenziswa njengamanje, ngaphambi kokuqala ukuthatha i-ACE inhibitors.
Abantu abakwi-ACE inhibitors kufanele bahlole abahlinzeki babo bezempilo ngaphambi kokuqala imithi emisha.
Imithombo:
Bakris, uGeorge L. "Ukwelashwa Kwesifo Sokushisa Kwesifo Esiyisifo Sikashukela Mellitus." UpToDate.com. Dec 11, 2015. UpToDate .. (ukubhalisa).
U-Kaplan, uNorman M., noBurton D. Rose. "Inhibitors ye-ACE ekuPhilweni kwe-Hypertension." UpToDate.com. 2014. UpToDate. (ukubhalisa)
UMcCulloch, uDavid K., noRa. Paul Robertson. "Ukubikezela nokuvimbela uhlobo lwesifo sikashukela se-Mellitus." UpToDate.com. 2007. UpToDate. 7 Sep. 2007. (ukubhalisa).