Iziguli Ezinezidingo Eziphuthumayo Zemibuzo Ingase Yiphendule E-ER Opioid Analgesics
Ukunakekelwa Okungenele Kwezinhlungu Ze-Osteoarthritis Kudala Izinkinga Ezengeziwe
Ngokombiko we-2008 American Journal of Therapeutics , ubuhlungu obungapheli obuhlobene ne- osteoarthritis kuthinta isiguli ngokubangela:
- izinga eliphansi lokuphila
- ukunciphisa noma ukulala okuphazamisayo
- ubudlelwano bezenhlalakahle obuhlupheka
- umsebenzi wehla wokucabanga unciphile (ukucabanga, inkumbulo)
- ukulinganiselwa kwimisebenzi yokuphila yansuku zonke
- ukukhiqiza okuphansi
- ukukhathazeka okwedlulele nokucindezeleka
Ukuphazamiseka kokulala - okubangelwa ubuhlungu - kuyinkinga enkulu yeziguli ze-osteoarthritis. Iziguli eziningi ze-osteoarthritis zinenkinga yokulala, ukulala kwesondlo noma ukuvuka. Ukuze ubhekane nazo zonke lezi zinkinga, ubuhlungu be-osteoarthritis kufanele buphathwe kahle.
Iziguli eziningi ze-osteoarthritis zithola uhlobo oluthile lwezokwelapha , kodwa ezimweni eziningi kakhulu, azitholi usizo olufanele lobuhlungu. Imiphumela yokufunda ibonise ukuthi iziguli ezingaphezu kuka-3 100 ze-osteoarthritis, 25% babike ukunganeliseki ngemithi yabo yobuhlungu. Kulelo qembu elingenelisekile, u-63% wabika ukusizwa okungenakwanele kobuhlungu kanti amaphesenti angu-17 abike imiphumela emibi.
Ukuthatha amaphilisi oHlelo kungathuthukisa ukusebenza
Ukuze iziguli ezibuhlungu ezingapheli, kungcono ukuthatha imithi yobuhlungu esimisweni. Umgomo wesimiso somuthi wokuphuza ubuhlungu uthatha umthamo olandelayo wemithi yobuhlungu ngaphambi kokuba umthamo owedlule uphelelwe.
Inkinga, ngezizathu ezihlukahlukene, iziguli eziningi ze-osteoarthritis azithathi imithi yobuhlungu ngesikhathi, futhi zivumela ubuhlungu babuyele - bese bexosha ubuhlungu ngomunye umthamo. Imithi yokwelashwa isikhathi eside noma yokwedlula isikhathi ingasebenzisa kangcono iziguli ezithola kunzima ukunamathela esimisweni.
I-Menu Ye-Analgesics - Yikuphi Okufanele Uyikhethe?
Iziguli ze-osteoarthritis ezisanda kutholakala ngokuvamile zizama i-acetaminophen - ibhekwa njenge-analgesic yokuqala ye-osteoarthritis. Ama-NSAID (izidakamizwa eziphikisayo ezingezona ukuvuvukala) kanye nama -inhibitors we-COX-2 nawo asetshenziselwa ukulawula ubuhlungu be-osteoarthritis, ikakhulukazi uma udinga ukukhululeka okuningi kune-acetaminophen. Ukuze ubuhlungu obukhulu, odokotela bacabangela ukuhlaziywa kwe-opioid okungasetshenziswanga njenge- tramadol nama-analgesics aphethwe ama-opioid (izinto ezilawulwayo).
Iyini Imithi Ephuthumayo Yobuhlungu?
Imithi yokwelashwa enhle izokubekezelela kahle, ilula, futhi ihlinzekele ukuphulukiswa kobuhlungu be-clock-clock. Kungaba namandla okuhlukunyezwa okungenani kanye nethuba elincane lemiphumela emibi kanye nobuthi obusetshenziswa isikhathi eside. Ingabe i-analgesics ye-opioid enwetshiwe (ER) ephuthumayo (ER) imithi emibi kakhulu yobuhlungu? Kwezinye iziguli, yebo. Kodwa iziguli zisebenzisa ama-analgesics e-ER opioid kumele ziqaphele izenzakalo ezingahle zenzeke futhi kumele zisebenzise kuphela izidakamizwa njengoba kunqunyiwe.
I-ER Opioid Analgesics ingaba ngempumelelo uma isetshenziswe kahle
I-morphine ER, ER oxymorphone, CR (ukukhululwa okulawulwayo) i-oxycodone, i-ER transdermal fentanyl, ne-ER tramadol ziphakathi kwezidakamizwa zokukhululwa ezenziwe nge-opioid ezingase zibhekwe njengokunciphisa ubuhlungu be-osteoarthritis.
Abacwaningi baphethe ngokuthi uma i-acetaminophen ne-NSAID engasasebenzi, noma i-osteoarthritis iyanda kakhulu - i-ER tramadol ingaba yindlela elandelayo engcono - ngaphambi kokuzama ukuhlela, ama-analgesics opiiid.
I-ER tramadol inezinzuzo ezithile ngaphezu kwamanye ama-analgesics e-opioid. Okokuqala, i-tramadol iholela emiphumeleni embalwa kunezinye i-opioids. Ukukhathazeka ngokusetshenziswa kabi kwezidakamizwa, ukubheja ngokweqile, ukubekezelelana nokuhoxiswa kuvamile kuma-analgesics e-opioid. Ama-analgesics e-opioid (kufaka phakathi ama-analgesics e-ER opioid) angabangela izinkinga nge-sedation, ukudideka nokuqothulwa, ikakhulukazi kuziguli ezindala.
Njenganoma yimiphi imithi, iziguli kumele zixoxe nodokotela wazo mayelana nezinzuzo ezihambisana nezingozi zokuthatha ama-analgesics e-opioid.
Ngenkathi kunesidingo sama-analgesics opioid kwezinye iziguli ezingazange zisabele kahle noma ziyeke ukuphendula ku-acetaminophen, ama-NSAID, nama-analgesics e-tramadol-opioid awafanelekile kuzo zonke iziguli.
I-ER izinguqulo ze-morphine, i-fentanyl, i-oxymorphone, ne-oxycodone zihlelelwe, izilinganiso ze-opioid ezinde isikhathi eside:
- I-morphine ye-ER iboniswa ukwelashwa kokulinganisela ebuhlungu obukhulu obungapheli kwezinye iziguli ze-osteoarthritis. Umgomo wokuthatha lesi sidakamizwa uhambile ukukhululeka kobuhlungu bewashi nokuthuthukiswa okuphawulekayo emgangathweni wokuphila.
- I-oxymorphone ye-ER ilinganisiwe njengehle kakhulu, inhle kakhulu, noma inhle ngamaphesenti angama-80% ocwaningweni. Lanikeza usizo lokuphumula oluphumelelayo nokuthuthukiswa kokusebenza kweziguli ezinezinhlungu ezingapheli ze-osteoarthritis.
- I-CR i-oxycodone iphumelela ekunciphiseni ubuhlungu obubangelwa i-osteoarthritis nokuthuthukisa izinga lokuphila. Kodwa-ke, i-oxycodone yisidakamizwa esivame ukuhamba emisha ngokuphathelene nokusebenzisa kabi izidakamizwa.
- I-ER transdermal fentanyl kufanele isetshenziswe kuphela yiziguli ezivele zithola ukwelashwa kwe-opioid futhi zibonise ukubekezelelana kwe-opioid. Iphumelela ekunciphiseni ubuhlungu obukhulu obukhulu be-osteoarthritis.
Akufanele uphile ngokubuhlungu okungapheli. Xoxani ngokuphathwa kobuhlungu nodokotela wakho futhi ungakhohlwa ukubuza mayelana nokuhunyushwa kokukhululwa kwama-analgesics opioid. Akuzona ukhetho olungcono kakhulu ukwelashwa kuzo zonke iziguli - kodwa ingabe ukhetho lwezokwelapha kuwe?
Umthombo:
Uhlu lwezifiso zami Sebenzisa Thenga ikhadi lesipho Thenga isikweletu se-Google Play Cover art Osteoarthritis I-American Journal of Therapeutics 15,241-255 (2008). UGibofsky, u-Allan noBarkin, uRobert L.