Amaphesenti angaba ngu-18 azo zonke izimo zomdlavuza emhlabeni jikelele angase ahlotshaniswe namagciwane, ngokulinganiselwa okukodwa. Kodwa-ke, ukuvezwa kwegciwane, yedwa, okwanele kungabangela ukulimala ezimweni eziningi. Kunezinye izici ezibalulekile ezithandwayo, kufaka phakathi izakhi zakho zofuzo kanye nokwehluka kwamanye emzimbeni omzimba omzimba ekungeneni kwezifo ezivela kulezi zifo.
I-Lymphoma iyinhlamba ehlanganisa i- lymphocytes , uhlobo lwe-white cell cell. I-Hodgkin's lymphoma, noma i-HL, ne-non-Hodgkin's lymphoma, noma iNHL, yizigaba ezimbili eziyinhloko ze-lymphoma. AmaGciwane aye ahlanganiswa nokuthuthukiswa kwamacala kokubili i- HL ne-NHL . Ama-parasites afana ne-malaria, ama-virus afana nokudala i-mono, namabhaktheriya anjengezinto eziphilayo ezihlobene nezilonda zesisu sezifakiwe ekuthuthukiseni i-lymphomas ehlukahlukene.
I-VIRUSES:
I-EBV ne-Burkitt Lymphoma
I-EBV yigciwane elibangela i- mononucleosis, noma i-mono , kwentsha kanye nabantu abadala; Nokho, emazweni asathuthuka, ukutheleleka kwe-EBV okwenzeka kusenesikhathi sokuphila futhi izimpawu ezimbalwa ezivamile zivame kakhulu. I-Burkitt lymphoma noma i-BL yi-NHL ejwayelekile kunazo zonke ezinganeni nasebancane emhlabeni jikelele. Lesi sifo sabizwa ngokuthi uDkt Denis Burkitt, owayengumhlinzeki ohlinzayo wase-Ireland owayesebenza e-Afrika. Ukutheleleka kokuqala kwegciwane le-Epstein-Barr, noma i-EBV, kuhlotshaniswa ne-Burkitt lymphoma.
Ukuthola ukutheleleka kwe-EBV empilweni yokuqala kuhlotshaniswa ne-HL nesifo se-lymphoproliferative ngemuva kokufakelwa komzimba.
I-HIV ne-Lymphoma
Iziguli ezinegciwane lesandulela ngculazi zifakwe ezinhlobonhlobo ze-non-Hodgkin lymphomas, kuhlanganise neBurkitt lymphoma. I-Burkitt lymphoma futhi isakaza i-B-cell lymphoma enkulu, noma i-DLBCL, yi-two ye-lymphomas ehambisana ne-HIV evamile.
Ezimweni ze-Burkitt lymphoma ezihlotshaniswa ne-HIV, iziguli ezingamaphesenti angama-30 kuya kwangu-50 nazo ziyi-EBV-positive. Impendulo ye-immune engalungile ngokumelene ne-EBV kubantu abane-HIV kucatshangwa ukuthi ifaka isandla ku-BL.
I-Adult T-Cell Leukemia-Lymphoma
I-T-cell ye-Adult T-cell leukemia-lymphoma, noma i-ATL, iyingozi ye-T-lymphocytes eyabangelwa yi-T-cell lymphotropic virus type-1, noma i-HTLV-1. I-HTLV-1 ayidlangalaleni eNyakatho Melika, kodwa iningi ezindaweni zaseJapane, e-Afrika naseCaribbean. Ngokufanayo nokutheleleka kwe-EBV, abantu abaningi abakha i-HTLV-1 abanayo izimpawu ezibonakalayo zokutheleleka.
Ama-PARASITES:
I-Malaria ne-Burkitt lymphoma
U-Burkitt nozakwabo bathola i-BL ngo-1957, lapho kwakukhona khona amacala ezindaweni ezihlala khona lapholaleveva-okuthiwa i-lymphoma belt. Kodwa-ke, i-Malaria yi-parasite eyenza amangqamuzana egazi abomvu, hhayi amangqamuzana amhlophe egazi lymphoma, ngakho-ke indlela eqondile yayisiyimfihlakalo iminyaka engu-50.
Nokho, ehlobo lika-2015, ukukhanya okunye kukhishwe ngale ndaba, nakuba kuhlolwa kwezilwane. Ukusebenza kwamagundane, abacwaningi eYunivesithi yaseRockefeller eholwa nguMichel Nussenzweig kanye nosebenza nabo bathola ukuthi i-enzyme efanayo esiza ukwenza ama-antibodies alwe ne-malaria futhi ibangela ukulimala kwe-DNA okungabangela i-Burkitt's lymphoma.
Ucwaningo lwanyatheliswa ngo-Agasti 13 encwadini ethi "Cell."
I-BACTERIA:
Ngaphezu kokubangela izilonda zesisu, ukutheleleka isikhathi eside nge-Helicobacter pylori, noma i-H pylori, kungabangela ushintsho emgqeni wesisu okungabangela umdlavuza ngokuhamba kwesikhathi.
H. Pylori ne-MALT Lymphoma yesisu
I-malignancy ebizwa ngokuthi i- marginal zone lymphoma ye-mucosa-ehlobene nezicubu ze-lymphoid ibizwa ngokuthi i-MALT, okwesikhashana. I-Gastric MALT lymphoma iyinhlobo engavamile ye-NHL. Ilandisa okungaphansi kuka-1 kwangu-20 emdlavuza oqala esiswini. I-gastric MALT lymphoma ihilela i-B-lymphocytes, uhlobo lwe-immune cells, esiswini sokugaya.
Coxiella Burnetii kanye nabanye
Ama-bacteria abangela ukutheleleka okuthiwa i-Q Fever-Coxiella burnetii-adonswa ubisi, umchamo, namanzi futhi abe khona emithonjeni yama-amniotic yezilwane ezithathelwanayo, ngokwe-CDC. Izinkomo, izimvu, nezimbuzi yizona eziyinhloko ezisemlonyeni wesilwane. Abahlengikazi kanye nabantu abasebenza nemfuyo basengozini enkulu. Ukuhlanganiswa kwezimpawu kuyahluka kakhulu kusuka komuntu kuya komuntu-futhi abantu abaningi abanakho izimpawu nhlobo-kodwa lapho bekhona, izimpawu zingabandakanya ukukhulelwa okukhulu, ukukhanda ikhanda, ukukhathala, ama-aches nezinhlungu, ama-chills, i-nausea, ukuhlanza nokuhuda.
Kwase kwesikhashana, kucatshangwa ukuthi abantu abane-lymphoma bangengozini enkulu ye-Q fever. Umsebenzi wakamuva owabikwa ngo-Oktoba 2015 wephephandaba elithi "Igazi" libonisa ukuhlangana phakathi kwezifo ezimbili eziya kwenye indlela: abaphenyi bahlola iziguli ezingu-1,468 eziphathwe eFrance National Referral Center yeQ Fever kusukela ngo-2004 kuya ku-2014, zathola eziyisikhombisa abantu abahlakulela i-lymphoma ngemuva kokutheleleka kweC C. burnetii. Iziguli eziyisithupha zatholakala ukuthi zine-B-cell lymphoma enkulu futhi i-follicular lymphoma. Lezi kanye nezinye amabhaktheriya zingaba nesixhumanisi se-causal ku-lymphoma kwezinye izimo, kodwa ucwaningo olubheke kulo mbuzo luyaqhubeka.
Izwi kusuka
Indima yama-bacteria, ama-virus kanye nama-parasites ekuthuthukiseni i-lymphoma iyathakazelisa, kodwa ingxenye eyodwa kuphela ye-puzzle-futhi leyo nhlaziyi kungenzeka noma ingafaneleki kumuntu one-lymphoma nohlobo lwakhe oluthile kanye ne-subtype ye-lymphoma .
Uma uvame ukucindezeleka ngamagciwane, ungavumeli lokhu kungeza ezintweni zakho ezikhathazayo. Eziningi ze-lymphomas, imbangela ayiyazi kahle. Futhi, ngisho nakulezo zitholampilo ezixhunyaniswe kakhulu nokuba khona kwegciwane, isibonelo, ukutheleleka ngegciwane elinjalo alanele, ngokwalo, ukudala i-lymphoma.
> Imithombo:
> Vedham V, Verma M, noMahabir S. Ukuqala kokuphila kwezilwane ezithathelwanayo kanye nokuthuthukiswa komdlavuza kamuva. I-Cancer Medicine . 2015. [I-Epub ngaphambi kokuphrinta]
> Miles, R., S. Arnold, noMnu Cairo. Izingozi kanye nokwelashwa kwengane kanye nentsha ye-Burkitt lymphoma / leukemia. Br J Haematol. 2012; 156 : 730-743.
> IYunivesithi yaseRockefeller. I-Science News. Ucwaningo olusha lusiza ukuthi kungani umdlavuza wegazi obulalayo uvame ukubathinta izingane ezine-malaria. Ifinyelele ngo-Okthoba 2015.
> Melenotte C, Million M, Audoly G, et al. I-bacterium ebangela i-Q fever exhunywe ku-non-Hodgkin lymphoma. Igazi . 2015
> Robbiani DR, Deroubaix S, Feldhahn N et al. I-Plasmodium Infection Ikhuthaza Ukukhubazeka Kwe-Genomic kanye ne-AID-Axhomekile B Cell Lymphoma. I-Cell 13 Agasti 2015; 162 (4): 727-737.