Ngo-2011, lapho i-United States Yokudla neDrug Administration (i-FDA) ivumile iBenlysta (belimumab) kwakuyinto enkulu! UBenlysta wayengumuthi wokuqala ovunyelwe i-lupus eminyakeni engaphezu kwengu-50. Ngaphambi kwalokho, izidakamizwa kuphela ezivunyelwe i-FDA ukuphatha i-lupus zaziyi-Plaquenil (i-hydroxychloroquine), i-prednisone (1955), ne-aspirin (1948). Kodwa i-Plaquenil ayidalwanga futhi ayisetshenziselwa kuphela i-lupus. Ubizwa ngokuthi umuthi we- anti - malaria ngoba usetshenziselwa ukuvimbela i-malaria, futhi isetshenziselwa ukwelapha isifo samathambo.
Uma uzwa ngeBenlysta, uzovame ukuzwa igama elithi biologic . Ngokungafani nezidakamizwa ezenziwe ezikhathini zamakhemikhali, i-biologic iyisidakamizwa esakhiwe emithonjeni yemvelo njengesilo, isintu noma i-microorganism. UBenlysta uhlukile ngoba ezinye zezinto eziphilayo zifikile ngaphambi kwayo futhi zahluleka njengezokwelapha.
Ngaphezu kwalokho, uBenlysta yiyona yokwelashwa okuqala okubhekiswe kuyo i-lupus. Ezinye izidakamizwa ezivame ukusetshenziselwa ukwelapha i-lupus-like hydroxychloroquine, i-corticosteroids, methotrexate, i-azathioprine, i-cyclophosphamide, ne-mycophenolate mofetil-yenzelwe ezinye izinjongo ukuvimbela isistimu yomzimba ngokubanzi. Kodwa ngenxa yokuthi uBenlysta uyi-biologic, eyakhiwa amaprotheni omuntu, abacwaningi bakwazi ukuthuthukisa umuthi ongaqondisa ingxenye ethile ye-immune system edlala indima ekwenzeni izimpawu ze-lupus.
Njengokwelashwa kokuqala kwe-biologic lupus, uBenlysta akahlinzeki nje ukwelashwa kuphela, kodwa uye wakhuthaza ucwaningo olusha olusha nolwazi olusha. Ngenxa yalezi zizathu, ukugunyazwa kwe-FDA kwezidakamizwa kuyisikhathi esibalulekile emlandweni we-lupus ucwaningo!
Ngokwemvelo, othile ofunda ngoBenlysta okokuqala angathanda ukwazi okwengeziwe ngomuthi. Ngezansi izimpendulo zemibuzo evamile ngoBenlysta.
UBenlysta Usebenza Kanjani?
Ngokusho kweLupus Research Alliance, uBenlysta "usebenza ngokunciphisa uhlelo lokuzivikela komzimba lwe-lupus ngokuvimbela iphrotheni okuthiwa i-'B lymphocyte stimulator '(BLyS)' ikholelwa ukwandisa ukusabela okuvuvukala okuhlasela nokulimaza izicubu zomzimba."
Ngamanye amazwi, i-BLYS iyinxenye yesimiso sokuzivikela somzimba esibhekene nezidakamizwa. UBenlysta ihlose ukuvimbela i-BLyS ekusebenziseni ukuvuvukala okubangela ukuthi isimiso somzimba sokuzivikela sikwazi ukuhlasela umzimba womuntu.
U-Benlysta uvame ukusetshenziselwa ukuhambisana neminye imithi ye-lupus (therapy ejwayelekile). Inhlanganisela iboniswe ukuthi iyasebenza kakhulu ekunciphiseni izimpawu ze-lupus kunezokwelapha ezivamile kuphela. Izimpawu ezincishisiwe zivame ukuhlobene nesikhumba, umlomo, amalunga nemisipha, kanye nesistimu yomzimba.
Enye inzuzo engaba khona yalesi sidakamizwa ukunciphisa ukusetshenziswa kwe-corticosteroid. Lokhu kubalulekile njengokwelashwa kwesikhashana, i-corticosteroids iyaziwa ukuthi ibangele imiphumela emibi njengokulahlekelwa kwethambo nokulimala komzimba.
I-Benylsta iphathwa kanjani?
Ngokungafani nezinye izifo eziningi ze-lupus, uBenlysta akuyona iphilisi. It is administered by intravenous (IV) ukumnika noma ngokusebenzisa self-injection.
Ukumnika IV
Le ndlela ivumela umuthi ukuthi ungene ngqo egazini bese ugoqa isisu. Uma ngabe igwiliswe ifomu lephilisi, lingangena emathunjini nasezintheni ezibalulekile ezakhiwa izidakamizwa zizobhujiswa.
Uma ilawulwa yi-IV ukumnika, awukwazi ukuyihambisa ekhaya futhi kufanele uhambe endaweni ethile ye-ukumnika njengehhovisi lakho lodokotela, isibhedlela, noma isikhungo sokungeniswa. Ukumnika kungathatha cishe ihora, kepha isikhathi eside uma isikhathi sokulungiselela nes / noma sokubheka kuyadingeka.
Ngama-infusions amathathu okuqala, kuyinto evamile ukuba kwenzeke kanye njalo ngemva kwamasonto amabili, futhi kanye kanye emva kwamasonto amane emva kwalokho.
I-Benlysta ihloswe njengemithi yesikhathi eside, futhi uma wena nodokotela wakho nivuma ukuthi kusebenza kahle kuwe, ungabeki ukumisa uma uqala ukuzizwa ungcono. Kufanele uqhubeke ukwelashwa ngisho nangemva kokuba uzizwa ungcono njengendlela yokugcina izinzuzo zayo ezinhle.
Ukuzilimaza
Kukhona imizamo yokunikeza ukhetho lokuzibulala, okusho ukuthi uzoba nokukhetha ukuphatha u-Benlysta ngokwakho, ekhaya. I-FDA ivume ukhetho lokuqala lokuzijoza ngo-2017, ikakhulukazi lwe-lupus erythematosus yesistimu, ifomu elivame kakhulu le-lupus. Ukukhetha ukwelashwa kudinga ukuqeqeshwa okuncane kudokotela wakho futhi kungase kube lula kune-IV kwabaningi.
Ngizwa ukuthi Akusebenzi Kubantu base-Afrika baseMelika
Izifundo zokuqala ezaholela ekuvunyweni kukaBenlysta akuzange zibandakanye abahlanganyeli base-Afrika nabamaMelika. Lokhu akusho ukuthi izidakamizwa ngeke zikusebenzele uma u-African-American. Ngokuphambene nalokho, kungase kusebenze kahle ngoba wonke umuntu one-lupus ehlukile.
Kukhona okwamanje ukuvivinywa komtholampilo okuqhubekayo ukusisiza ukuthi sifunde kabanzi mayelana nokuthi iBenlysta iphumelele kangakanani kwabase-Afrika-baseMelika. Lezi zivivinyo zibaluleke kakhulu ngoba abesifazane base-Afrika nabamaMelika bangamathuba amathathu okuthuthukisa i-lupus kunabesifazane abamhlophe.
Khuluma nodokotela wakho uma unesithakazelo ekuzameni uBenlysta noma ukuhlanganyela esilweni sesilingo saseBenlysta.
Kuthiwani uma Ngine-Inhlanganisela Yomzimba?
Lapho uBenlysta evunyelwa yi-FDA kuqala, kwakungacacile ukuthi ngabe lesi sidakamizwa sizozuzisa abantu abanezimboni njenge-lupus nephritis noma isimiso sezinzwa zomphakathi (CNS) lupus. Kodwa-ke, kokuhlaziywa kocwaningo olulodwa, kwatholakala ukuthi phakathi neminyaka emihlanu yokuqala yokwelashwa noBenlysta, lesi sidakamizwa asizange sibangele noma senze umonakalo owenziwe ngomzimba sibi nakakhulu, futhi kungase kube nokuphuza kwesifo sokukhula okuhlobene nokulimala komzimba. Njengoba lokhu kwaba ulwazi olusekelwe ekuhlaziyweni okucwaninga olulodwa oluhlangene nezifundo ezimbili, ucwaningo olwengeziwe luzozuzisa. Ucwaningo luthembise, ngakho-ke uma unesitho somzimba futhi unesithakazelo ekuzameni uBenlysta, khuluma nomuntu wakho we-rheumatologist ukubona ukuthi bacabanga ukuthi lokhu kuyindlela enhle kuwe.
Yiziphi Imiphumela Ezingezansi Nezingozi?
Njengazo zonke izidakamizwa, uBenlysta angabangela imiphumela emibi futhi eze nezingozi. Ikhamphani yezidakamizwa kumele ixwayise ngazo zonke imiphumela emibi ekwaziwayo, kepha lokhu akusho ukuthi uzozizwa lezi. Uma ukhathazekile ngemiphumela emibi, kubalulekile ukukhuluma nama-rheumatologists akho mayelana nokukhathazeka kwakho. Ezimweni lapho abantu benza imiphumela emibi, bangase banqume ukuqhubeka nokwelashwa uma imiphumela emibi engekho enkulu noma uma bona nodokotela wabo bezwa ukuthi izinzuzo zomuthi zingaphezu kwemiphumela emibi.
Ngenxa yezingozi ezihlobene noBenlysta, ngaphambi kokuqala umuthi, tshela i-rheumatologist yakho uma:
- banezibonakaliso noma baye bathola ukuthi banesifo, isifo senhliziyo, noma ukugula kwengqondo
- sidinga noma sithole nje ukugoma, ikakhulukazi umgomo wokuphila
- ube nemithi yokwelapha
- bathatha omunye umuthi we-biologic, ama-antibodies monoclonal noma i-IV infusions ye-cyclophosphamide (i-Cytoxan®)
- kukhona kunoma yiluphi olunye uhlobo lwemithi, ukwesekwa kwe-herbal, noma i-vitamin
- unake noma waba nanoma yiluphi uhlobo lomdlavuza
- banezinye izimo zezokwelapha
- ukhulelwe noma uhlela ukukhulelwa, noma uma ukondla
Lolu lwazi luzosiza udokotela wakho ukuba anqume ukuthi u-Benlysta uyindlela yokwelapha efanele futhi isikhathi esihle sokuqala ukwelashwa. Isibonelo, uma une-infection, kuzodingeka baphinde bayeke ukwelashwa njengoba isidakamizwa sandisa ingozi yokutheleleka.
Uma noma yikuphi kwezimo kwenzeka uma usuvele usezidakamizwa, kufanele utshele i-rheumatologist yakho.
Ngesikhathi uvivinyo lwezokwelapha, abantu bahlangabezana nemiphumela emibi, kepha akusobala ngaso sonke isikhathi uma imiphumela emibi ibangelwa ngqo yilo muthi. Kodwa-ke, abacwaningi-futhi kulokhu uGlaxoSmithKiline (GSK), abenzi bezidakamizwa-kumele babhale noma yiziphi izimpawu ezingalungile abantu ababhekana nazo ngesikhathi sokuhlolwa kwamagciwane.
Imiphumela emibi kakhulu yeBenlysta yilezi
- isiyaluyalu
- isifo sohudo
- umkhuhlane
- impumulo ephuthumayo noma egijima
- Umphimbo obuhlungu
- ukukhwehlela (bronchitis)
- inkathazo yokulala
- ubuhlungu bomlenze noma wesandla
- ukucindezeleka
- ikhanda (i-migraine)
- ukutheleleka kwe-urinary tract
- kunciphise isibalo segazi esimhlophe (i-leukopenia)
- ukuhlanza
- ubuhlungu besisu
Uma uhlangabezana nalezi noma imiphumela emibi kakhulu, kubalulekile ukutshela i-rheumatologist yakho ngokushesha. Uma uhlangabezana nemiphumela emibi yokuphila, njenge-reactionergic reaction eyenza ukuphefumula kwakho, shayela u-9-1-1 ngokushesha.
Kuneminye eminye, okungavamile, imiphumela emibi. Zibalwe kwiwebhsayithi le-GSK, kodwa kubalulekile futhi ukukhuluma ne-rheumatologist yakho ngemiphumela emibi yeBenlysta nezingozi, ngokujwayelekile.
Ungaphinda ubike imiphumela emibi yabezidakamizwa, hhayi nje uBenlysta, ku-FDA. Vakashela i-www.fda.gov/medwatch, noma shayela u-1-800-FDA-1088.
Ingabe Ngizokwazi Ukukhathazeka Benlysta?
Nakuba uBenlysta iyindlela yokwelapha ebiza kakhulu, i-GSK inikeza ukusekelwa kwezimali. I-rheumatologist yakho ingasebenza nomshuwalense wakho kanye ne-GSK ukuthola usizo lwezezimali oyodinga.
Ingabe uBenlysta Usebenzela Izingane ZineLupus?
Akukaziwa ukuthi ngabe uBenlysta uphephile futhi usebenza kanjani kubantwana abane-lupus. Kukhona isifundo se-lupus esiqhubekayo sezingane esihlola ukusebenza nokuphepha kukaBenlysta kubantwana abane-lupus phakathi kweminyaka engama-5-17 ubudala. Uma ingane yakho ine-lupus, ungakhuluma nodokotela wakho ukuthi kufanele yini ukubhalisa lesi sifundo.
Ingabe Kukhona Izinkinga Zemitholampilo Benlysta?
Yebo. Uma ungathanda ulwazi oluthe xaxa mayelana novivinyo lwezokwelapha lwaseBenlysta, ungakhuluma ne-rheumatologist yakho noma uxhumane ngqo ne-GSK ngqo. Ungaphinde uvakashele i-clinicaltrials.gov bese uthayipha u- Benlysta ebhokisini lokusesha.
Ingabe Kuphephile Ukuthatha I-Benlysta Isikhathi Eside?
Abacwaningi bacwaninga imiphumela kaBenlysta kubantu abaye bathatha lesi sidakamizwa iminyaka emihlanu futhi bathole ukuthi, kuze kube manje, izidakamizwa ziphephile ukuthatha lesi sikhathi. Abatholanga ukwanda kwemiphumela emibi eyaziwayo kakade.
Kuthiwani Uma Ngikhulelwe Noma Ngifuna Ukubelethwa?
Ngenkathi kube khona abesifazane abaye babeletha ngokuphumelelayo ezinganeni ezinempilo ngenkathi bethatha uBenlysta, abacwaningi basacwaninga uma kuphephile ukuthatha uBenlysta ngenkathi ekhulelwe-ingabe isidakamizwa sidluliselwa emntwaneni futhi uma kunjalo, kuyini umthelela? Abacwaningi baqoqe futhi bahlaziya idatha ethile kodwa idatha eyengeziwe iyadingeka.
Uma ukhulelwa ngenkathi uthatha uBenlysta noma ezinyangeni ezine ngemuva kokuyeka lesi sidakamizwa, sitshele ngokushesha i-rheumatologist, futhi ubuze nabo nge-Belimumab (Benlysta ™) Registry Pregnancy.
Ngokubheka kanye nokuqoqwa kwedatha, irejistri iklanyelwe ukusiza abacwaningi ukuthi baqonde kangcono umthelela kaBenlysta ekukhulelwe. Wena nomntanakho uzobe uhlolwe ngokucophelela uma unquma ukuhlala esidakamizweni.
Kwezinye izimo, abantu bangase banqume ukuhlala ku-Benlysta lapho bekhulelwe uma izinzuzo zokuhlala ezidakamizweni zinkulu kunomthelela omubi ongase ube nawo emntwaneni.
Uma kungenjalo, kunconywa ukuthi usebenzise ukuvimbela ukukhulelwa ukuvimbela ukukhulelwa ngenkathi uthatha uBenlysta, noma kuze kube yizinyanga ezine emva kokuyeka lesi sidakamizwa.
Ngokufanayo, akukwazi uma lesi sidakamizwa sidlula kusukela kumzali kuya kwengane ngokuncelisa. Umzali kufanele akhethe phakathi kokuncelisa noma ukuthatha uBenlysta. Uma ucabangela ukubelesa, sicela ukhulume ne-rheumatologist yakho ezokusiza ukuba ubone ukuthi ungakhetha kanjani.
Ngithola kanjani izindaba zamanje nge Benlysta?
Ukuthola mayelana nanoma yikuphi ucwaningo lwamuva noma izindaba ezihlobene noBenlysta, ungakhuluma nodokotela wakho. Ungenza futhi usesho lwe-intanethi, uqinisekise ukuthi uthole imithombo ethembekile .
Enjini yakho yokusesha oyithandayo, ungangena igama lokusesha njengocwaningo lukaBenlysta 2016 (sebenzisa unyaka wamanje).
Imiphumela embalwa yokusesha ingabandakanya izixhumanisi ku-Lupus Research Alliance, noma ezinye izinhlangano ze-lupus ezihloniphekile. Izibonelo zamakhasi wezindaba ze-lupus zocwaningo ezinokwethenjelwa yi-MedPage Namuhla ne-Lupus News Namuhla. Lezi zingase zivele ekusesheni kwakho. (Funda kabanzi mayelana nokuthi ungathola kanjani ulwazi lwezempilo oluthembekile kwi-intanethi.)
Ungase uhlangabezane nezihloko ezishicilelwe ngu-GSK. Kuhlale kusiza ukuya ngqo enkampanini yezokwelapha futhi ubone ukuthi yikuphi ukukhishwa okusha okushicilelwe kamuva mayelana nokwelapha okuthile.
Uma ufuna ukuya ngqo ocwaningweni, i-PubMed yiwebhusayithi kahulumeni wase-United States enikeza ukufinyelela mahhala ku-database ye-National Library of Medicine okuthiwa i-Medline. Ngezinye izikhathi inikeza izihloko eziphelele. Ngezinye izikhathi inikeza iziqephu. I-abstract isifinyeto salesi sihloko.
Uma wenza usesho ku-PubMeb ye-Benlysta, uzothola imiphumela eminingi. Unganciphisa imiphumela ngokufaka ngegama lakho lokusesha. Esikhundleni sokufuna uBenlysta , funa imiphumela emibi yeBenlysta , isibonelo.
Ingabe i-Benlysta iyatholakala ngaphandle kwe-US?
Ngaphezu kokutholakala e-United States, iBenlysta itholakala kumazwekazi ayisithupha - eNyakatho naseNingizimu Melika, e-Afrika, e-Asia, e-Europe nase-Australia. Ukuze uthole ukuthi i-Benlysta iyatholakala yini ezweni lakini, khuluma ne-rheumatologist yakho. Ungase futhi ubize i-GSK. Ukuze uxhumane nabo uma uhlala ngaphandle kwe-US, vakashela isigaba sewebhu seWebhusayithi yonke futhi useshe ngesifunda.
Ingabe Benlysta Uzongisebenza Ngami?
Wonke umuntu one-lupus ungumuntu oyingqayizivele, ngakho ayikho impendulo elula yalo mbuzo.
Khuluma ne-rheumatologist yakho ukuthola ukuthi bacabanga ukuthi ungumuntu omele ukhetho lokwelashwa.
Uma wena ne-rheumatologist yakho ucabanga ukuthi kuyindlela enhle yokwelashwa, kuzomele uzame izidakamizwa ukuze ubone ukuthi ikusebenza kanjani. Khumbula ukuthi akusebenzi ngokushesha njengoba ukwelashwa njenge-corticosteroids. Kungathatha amasonto noma izinyanga ukuqala ukubona imiphumela.
Ucabanga ngoBenlysta? Khuluma Ne-Rheumatologist Yakho
Uma ucabangela uBenlysta, isinyathelo esilandelayo ukukhuluma nomuntu wakho we-rheumatologist. Ngokuvamile uzoba nemibuzo eminingi phakathi kwengxoxo yakho yokuqala mayelana nokwelashwa, kanye nanoma yisiphi isikhathi ngemva kwalokho, kufaka phakathi nesikhatsi uthatha lesi sidakamizwa. Bhala phansi imibuzo yakho njengoba ziphakama, futhi ulethe uhlu lwakho lwemibuzo ekuqokwa kwakho okulandelayo. Ungabiza futhi nge-GSK ngqo nge-BENLYSTA Gateway ngo-1-877-4-BENLYSTA (1-877-423-6597) ngoMsombuluko kuze kube uLwesihlanu, ngo-8 ekuseni kuya ku-8 PM Isikhathi sase-Eastern. Uma kuziwa empilweni yakho, unelungelo lokuba nolwazi ngangokunokwenzeka.
> Imithombo:
> Bruce I, Urowitz M, Vollenhoven R, et al. Umonakalo wesikhashana wesikhathi eside ukwandisa nokuphepha kuziguli ezine-SLE eziphathwe ne-belimumab nokunakekelwa okujwayelekile. Lupus. 2016; 0: 1-11. http://lup.sagepub.com/content/early/2016/02/18/0961203315625119.full.pdf+html.
> Dubey A, Handu S, Dubey S, Sharma P, Sharma K, Ahmed Q. Belimumab: Ukwelashwa Okuqala Okulindelekile Kwezokwelapha Lupus Erythematosus. I-Journal of Pharmacology & Pharmacotherapeutics. 2011; Okthoba-Dec; 2 (4): 317-319. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198539/.
> Landy H, Powell M, Hill D, Eudy A, Petri M. Belimumab Registry Yokukhulelwa: Ukufundwa KwamaCorporate OkuPhumela Emiphumeleni Yokukhulelwa. I-Obstetrics & Gynecology. 2014; 123 (1). http://journals.lww.com/greenjournal/Abstract/2014/05001/Belimumab_Pregnancy_Registry__Prospective_Cohort.130.aspx.
> Vollenhoven R, uPetri M, Wallace J, et al. I-Corticosteroid Dose Eqoqayo Ngamaviki Angamashumi Amabili Namashumi Amabili Eziguli Eziphethe I-Lupus Erythematosus Eyisistimu: Ukuhlaziywa Okuxubile Kusukela Ezivivinyweni Ze-Belimumab Phase III. I-arthritis ne-Rheumatology. 2016; 68 (9): 2184-2192. http://onlinelibrary.wiley.com/doi/10.1002/art.39682/abstract.