Yeka ukuthi i-Mono ingaba kanjani exhunywe engozini eyanda kakhulu ye-MS
Nakuba ososayensi abazi ukuthi iyini imbangela eqondile ye- multiple sclerosis (MS) , abaningi bakholelwa ukuthi kuwumphumela wokuzibandakanya okuyingqayizivele phakathi kwezici zomuntu nezakhi ezithile zemvelo. Eminye yalezi zici zingase zibandakanye ukuntuleka kwe-vitamin D , ukubhema , kanye nokutheleleka kwegciwane lesandulela ngculaza.
Eminyakeni yamuva, kugxile kakhulu kwigciwane le-Epstein-Barr (EBV) kanye nendima ebonakala ukuthi iyadlala ekuthuthukiseni kwe-MS.
Indlela i-Epstein Barr Virus esebenza ngayo
Igciwane le-Epstein-Barr yisisusa esivame kakhulu se- mononucleosis esithathelwanayo (isimo esibizwa ngokuthi "mono"). Liyilungu lomndeni we-herpes wegciwane futhi lisakazeka kalula kusuka komuntu kuya komuntu ngokusebenzisa amanzi omzimba, ngokuyinhloko.
Kulinganiselwa ukuthi abantu abaningi bayokwelashwa nge-EBV ngesikhathi esithile empilweni yabo, ngokuvamile ebuntwaneni, nakuba iningi lingasoze ligula. Uma benza, izimpawu zingabandakanya:
- Ukukhathala
- Fever
- Izinwele
- Ama-body aches
- Umhombo ovuthayo
- Ukuvuvukala i-lymph nodes entanyeni
- Ipeni ekhulisiwe
- Isibindi sokuvuvukala
- Rash
Izimpawu ngezinye izikhathi zingadla umzimba, zidinga ukuphumula kombhede, kodwa zithatha isinqumo emavikini amabili kuya kwamane.
Uma usulelekile, igciwane alishayanga neze kodwa lihlanganisa izinto eziphilayo zohlobo lwezakhi zofuzo zibe esitokisini esiphezulu futhi lihlala lapho esimweni esingasebenzi. Phakathi nalesi sikhathi okuthiwa "i-latency," igciwane alikwazi ukuthelela.
Kodwa-ke, izinto ezithile zingabangela igciwane elilindelekile ukuba liphinde liphinde liphinde liphinde liphinde liphinde liphinde liphinde liphinde liphinde libe khona, kufaka phakathi ukucindezeleka nokulala kokulala. Uma lokhu kwenzeka, lo muntu angase azwe ngokuzumayo izimpawu futhi akwazi ukudlulisela igciwane kwabanye.
I-Connection Between MS ne-EBV
Ekuhloleni izimbangela ezikhona ze-MS, ososayensi sekuyisikhathi eside bakholelwa ukuthi ama-virus angasiza ngandlela-thile ekuthuthukiseni lesi sifo.
Eqinisweni, abantu abangamaphesenti angama-95 abantu abane-MS bazoba nobufakazi bokutheleleka okudlule ngendlela yama-antibodies.
Ama-antibodies amaphrotheni avikelayo akhiqizwa ngumzimba ekuphenduleni i-agent esebenzayo. Ngamunye ucacile kuleyo agent futhi lelo agent lilodwa futhi likhonza njengamaselula "izinyawo" ekuthelelekeni okudlule. Yize kungavamile ukuba nama-antibodies egazini egazini lethu-sonke senza-kukhona amagciwane athile abonakala ahlobene kakhulu ne-MS.
I-Epstein-Barr igciwane ingenye yazo. Ngokwesayensi yamuva evela eHarvard School of Public Medicine, i-EBV yayihlukile kwezinye izigciwane ekuhlanganisweni kwayo ne-MS. Phakathi kokuthola:
Ama-antibodies e-EBV ayekhudlwana kakhulu kubantu abakugcina ama-MS kunesiqoqo esifanelana nabantu abangazange bathole lesi sifo.
Ingozi ye-MS yanda kakhulu ngokulandela ukutheleleka kwe-EBV.
Abantu abanegciwane elithile (HLA-DRB1) namazinga aphezulu e-antibodies e-EBV ayenamathuba ayisishiyagalolunye okuthuthukisa i-MS kunelabo abangenawo igesi kanye namazinga aphansi ama-antibodies e-EBV.
Ngaphezu kwalokho, ababhemayo bamanje nabangaphambilini abanezinga eliphezulu kakhulu lama-antibodies e-EBV babengamaphesenti angu-70 amathuba okuthuthukisa i-MS kunelabo abangenayo ingozi.
Amanye ama-Virus axhunyiwe ku-MS
Ngokuphelele kwazo, lezi zithole zinikeza ubufakazi obuqine kakhulu bokuthi i-EBV isebenza njengesifo se-disorder esithinta abangaphezu kuka-350,000 baseMelika.
Kodwa empeleni kungase kungabi yigciwane kuphela. Abacwaningi base-Australia baphinde bacacise i-herpesvirus-6 yomuntu (i-HHV-6), igciwane elifana ne-EBV okungaba cishe wonke umuntu onegciwane lesandulela ngculaza, ngokuvamile ngaphambi kweminyaka engamashumi amathathu.
Njengoba i-multiple sclerosis ikhathazekile, i-HHV-6 ayihlanganisi nje ngokunyuka okuphindwe kathathu engozini ye- MS eqhubekayo kubantu besifazane, amazinga aphakeme ama-antibodies eHHV-6 avela eduze kakhulu engozini yokuphindaphinda kwe- MS .
Nakuba kungekho okunye okubonisa ukuthi kukhona ukuphumelela kunoma yikuphi ukwelashwa noma ukuvimbela i-MS, kungenzeka ngelinye ilanga linikeza izindlela zokubikezela inkambo yesifo ngokulandelela i-EBV, HHV-6, noma ama-virus we-herpes afanayo.
> Imithombo:
> Leibovitch, E. and Jacobson, S. "Ubufakazi obuxhumanisa i-HHV-6 ne-Multiple Sclerosis: Isibuyekezo." Ama-Opinions amanje ku-Virology. 2014; 0: 127-33. .
> Levin, L .; Unger, K, O'Reilly, E. et al. "Ukutheleleka Okuyinhloko nge-Epstein-Barr Virus kanye Nengozi Ye-Multiple Sclerosis." Ama-Annal of Neurology. 2010; 67 (6): 824-30.