Ucwaningo olusha lubonisa ukuthi imithi yomdlavuza wesifuba ebizwa ngokuthi letrozole (i-Femara) ingase ibe yindlela engcono kune-Clomid yokuthuthukisa izinga lokukhulelwa kwabesifazane abane-PCOS. Lezi zindaba ezinhle zezigidi zabesifazane abahlukunyezwa yi-PCOS, imbangela ehamba phambili yokungasebenzi kwe-ovulatory e-United States.
UDkt. Richard Legro, isazi se-endocrinologist sokubeletha ePennsylvania Hershey Medical Centre sanikeze imiphumela yecala lakhe elixhaswe yi-NIH e-2012 American Association of Reproductive Medicine (ASRM) eyabonisa ukuthi abesifazane abangu-25% abaphathwa nge-letrozole babezalwa ngokuphila uma kuqhathaniswa kuya kuma-16.8% wabesifazane abathinte.
Ngokwesiko, i-Clomid ibe yisidakamizwa sokuqala sokuzikhethela ukugqugquzela ukuvuthwa kwamazinyo kwabesifazane abane-PCOS kodwa kunezinga eliphakeme lokukhulelwa okuphindaphindiwe futhi landa ukuvezwa kwe-estrogen. Uma kuqhathaniswa, i-letrozole ayiphakamisi i-estrogen-like Clomid, inengozi ephansi yokukhubazeka kwenhliziyo futhi inezinga eliphansi lokukhulelwa okuningi.
Kuyini i-Letrozole?
I-Letrozole iyi- inhibitor ye-aromatase evikela ukuguqulwa kwe-androgen ku-estrogen. Liphinde ithuthukise ubukhulu be-endometri futhi iphinde ikhuthaze ukuthuthukiswa kobuciko be-ovarian. Ngenkathi kungavunyelwe yi-FDA ngalokhu kusetshenziselwa, kuboniswe ukuthi kubangele ukuvuthwa kwabesifazane abangaboni. Ngenxa yalesi sizathu, ochwepheshe abathile abangenasifo sokubeletha basebenzisa izidakamizwa kwabesifazane abakwazi ukubekezelela noma abangaphenduli kahle ku-Clomid.
I-Letrozole yisidakamizwa esivame ukusetshenziselwa ukwelapha izicubu ezisekelwe e-estrogen, ikakhulukazi umdlavuza webele emadodeni amadala, emva kokumama-menopausal.
Ukuzikhohlisa:
I-Letrozole ifika ngamaphilisi angu-2.5mg futhi ithathwa kanye ngosuku ngezinsuku ezingu-5, ngokuvamile iqala ngosuku nosuku noma emihlanu yokujikeleza kokuya esikhathini . Ungadinga ukuqapha ngokusebenzisa ukuhlola kwegazi kanye / noma ama-ultrasound ukucacisa ukuthi usufika nini lapho ufika khona.
Okuqhamuka uma udla imishanguzo:
Ngokuvamile, i-letrozole ibekezelela kahle.
Imiphumela emibi ingafaka:
- ukukhathala
- inzuzo yesisindo
- ikhanda
- amathambo noma ubuhlungu besisu
- ukushisa okushisayo
Izingozi Zokukhubazeka Ukuzalwa:
Kubalulekile ukuqaphela ukuthi le mithi ayihambisani nokukhulelwa nokuncelisa. Kodwa-ke, sicela uqonde ukuthi uthatha lesi sidakamizwa ngaphambi kokuthi ukhulelwe, ngakho-ke akukhulisi ingozi yokuba nengane eneziphene zokuzalwa. I-Letrozole kufanele imiswe ngokushesha lapho ukhulelwe.
Ihlelwe yi-PCOS Expert Angela Grassi, MS, RDN
Imithombo:
I-Legro RS, i-Kunselman AR, i-Brzyski RG, i-Casson PR, i-Diamond i-MP, i-Schlaff WD, i-Christman GM, i- Coutifaris C, i-Taylor HS, i-Eisenberg E, i-Santoro N, i-Zhang H. Ukukhulelwa kwe-Polycystic Ovary Syndrome II (PPCOS II) kanye nokwakheka kwesilingo esiphambanweni esingenalutho esiphundu se-clomiphene citrate ne-letrozole ekwelapheni ukungabi nabantwana kulabo besifazane abane-polycystic ovary syndrome. Imizamo yokuKwelashwa kwe-Contemp. 2012 Meyi; 33 (3): 470-81.
U-Nayereh Ghomian, MD, u-Ashraf Khosravi, MD, noNezhat Mousavifar, uMsombuluko we-MD A ongenakuqhathaniswa nokuqhathanisa ukulinganisa kohlobo lwezinsuku ezimbili zokuqala ezihlukene ze-Letrozole Ukwelashwa ku-Clomiphene Citrate I-PCOS Yokulinda Iziguli ku-IUI Cycles. Int J Fertil Steril. 2015 Apr-Jun; 9 (1): 17-26.