Enye yezinto ezithengiswa kakhulu ezidliwayo ekudleni kwabantu base-PCOS i-inositol. Futhi ngesizathu esihle: kokubili izinhlobo ze-Myo (MYO) ne-d-Chiro-inositol (DCI) ze-inositol ziye zaboniswa ukuthuthukisa izici eziningi ze-PCOS. Lezi zinzuzo zihlanganisa ukuthuthukiswa kwe- cholesterol , i-insulini, i- androgens nesisindo. Abesifazane abathatha i-inositol babika izifiso ezimbalwa.
Okubaluleke nakakhulu, i-MYO iboniswe ukukhulisa ukuzala ngokuphucula ikhwalithi yamaqanda nokubuyisela ukujwayela kokuya esikhathini nokunciphisa ingozi yesifo sikashukela sokugaya.
Ngenkathi kokubili izinhlobo ze-MYO ne-DCI zinikeza izinzuzo eziningi kubesifazane abane-PCOS, ucwaningo olusha manje lubonisa ukuthi kuhlanganiswa kwalezi zinhlobo ezimbili, isilinganiso semvelo somzimba esibonisa inzuzo enkulu.
Kuyini i-Inositol?
I-Inositol iyilungu lamavithamini e-B kanye nengxenyana ye-membrane yeseli. I-inositol itholakala ekudleni okufana nezithelo, ubhontshisi, okusanhlamvu, namantongomane futhi yenziwa nomzimba. Ngenkathi kunezinhlobo eziyisishiyagalolunye ze-inositol, yi-MYO ne-DCI eziye zabonisa izinzuzo ezinhle ku-PCOS. Kungenxa yokuthi bakholelwa ukuthi abesifazane abane-PCOS bangase babe nenkinga emandleni omzimba okusebenzisa i-MYO ne-DCI, okufaka isandla ekumisweni kwe- insulin . Umsebenzi we-MYO no-DCI njengezithunywa ezimbili ezidlulisela izimpawu ezihileleke ekulawulweni kwe-insulin.
Izinzuzo zikaMyo noD-Chiro Inositol Zihlangene
I-MYO ne-DCI ziyi-molecule ehlukene esebenza ngokungafani emzimbeni.
I-DCI yenziwe kusuka ku-MYO uma kudingeka . Umzimba ugcina isilinganiso esijwayelekile sama-plasma e-MYO kuya ku-DCI angu-40: 1. Isilinganiso se-MYO kuya ku-DCI ku-flulicular fluid siphakeme kakhulu- 100: 1. I-follicle ene- oocyte ephezulu ine-concentration ephakeme kakhulu ye-MYO.
Ukungalingani kokulinganisa okujwayelekile kwe-MYO kuya ku-DCI kungathinta izinga leqanda.
Ngenkathi i-DCI eyedwa yenziwa ngezidakamizwa eziphakeme (600-2400 mg nsuku zonke) itholakala ukuthi ithinte kabi izinga le-oocyte kanye nempendulo ye-ovarian. Ngaphezu kwalokho, izinga eliphakeme le-DCI (futhi lingalinganisani isilinganiso se-MYO kuya ku-DCI), izinga elibi kakhulu le-oocyte kanye nokuphendula kwe-ovarian .
I-MYO ibhalwe kahle ukuthi iphakeme kune-DCI ekuthuthukiseni ukuvimbela i-insulin, ikhwalithi yeqanda nokunciphisa ingozi yesifo sikashukela esithathelwanayo kubantu besifazane abane-PCOS. Kodwa-ke, uma i-MYO ihlangene ne-DCI ngokulinganisa okuhle, imiphumela emihle ibonakala.
Esicwaningweni esashicilelwe emaphepheni we- Archives of Gynecology and Obstetrics , abesifazane abano-PCOS abaphila nge-IVF baphathwa ngokuhlanganiswa kwe-MYO ne-DCI ngokwesilinganiso se-physiologic esingu-40: 1 noma 500 mg we-DCI yedwa. Ukwelapha okuhlangene nakho kwakwazi ukuthuthukisa ikhwalithi ye-oocyte kanye ne-embryo, kanye nezinga lokukhulelwa, okubonisa ukuthi i-MYO idlala indima ebalulekile ku-ovary kuma-PCOS abesifazane kanye nezinzuzo ze-MYO ne-DCI ngokulinganisa okuhle.
Kwesinye isifundo eshicilelwe kulo nyaka kuyi- European Review for Medical and Pharmacological Sciences , abesifazane abakhuluphele ngokweqile abane-PCOS bathola i-MYO ne-DCI noma i-MYO kuphela ngezinyanga eziyisithupha. Ekupheleni kokwelashwa, ukuhlanganiswa okuhlangene ne-MYO ne-DCI kwakuphumelela ngokwengeziwe ekunciphiseni imingcele yemetrikhi uma kuqhathaniswa neqembu le-MYO.
Abalobi baphetha ngokuthi "ukuphathwa okuhlangene kwe-MI kanye ne-DCI ngokwezinga lomzimba we-plasma (40: 1) kufanele kubhekwe njengendlela yokuqala yokuqala ku-PCOS.
Yini Okufanele Uyazi Ngokuthatha Inositol?
Kunconywa ukuthi abesifazane abane-PCOS bathathe inani elihlangene le-MYO (2-4 amagremu) no-DCI (50-100mg) isilinganiso se-physiologic esingu-40: 1.
Ngokujwayelekile, i-MYO ne-DCI ibekezelela kahle kodwa ingabangela ushukela ophansi wegazi , ikakhulukazi uma uthatha imithi noma ezinye izithako ezithinta ushukela ophansi wegazi. Njengoba njalo, hlola nodokotela wakho ngaphambi kokuqala i-inositol.
> Imithombo:
> I-Costantino D, i-Minozzi G, i-Minozzi E, i-Guaraldi C. I-Metabolic ne-Hormonal Effects of Myoinositol kwabesifazane abane-Polycystic Ovary Syndrome: i-Double-Blind Trial. Ukubuyekeza kwe-Europ Med Pharmacol Sci . 2009; 13 (2): 105-110.
> Unfer V, Carlomagno G, Rizzo P, Raffone E, Roseff S. Myo-Inositol Kunokuba i-D-Chiro-Inositol Ikwazi Ukuthuthukisa I-Oocyte Quality in Intracytoplasmic Sperm Injection Cycles. Isivivinyo Esibheke, Esilawulwayo, Esihleliwe. Ukubuyekeza kwe-Europ Med Pharmacol Sci. 2011; 15 (4): 452-457.
> Le Donne M, Alibrandi A, Giarrusso R, Lo Monaco I, Muraca U. [Ukudla, Metformin kanye ne-Inositol ku-Overweight kanye nabesifazane abakhona abane-Polycystic Ovary Syndrome: Imiphumela yeComposition Composition]. Minerva Ginecologica. 2012; 64 (1): 23-29.
> Venturella R, Mocciaro R, De Trana E, D'Alessandro P, Morelli M, Zullo F. [Ukuhlolwa Kokuguqulwa Kwemitholampilo, I-Endocrinal ne-Metabolical Profile of Iziguli nge-PCOS Syndrome Ephathwe nge-MYO-Inositol]. Minerva Ginecologica. 2012; 64 (3): 239-243.
> Genazzani AD, Prati A, Santagni S, et al. Ukuhlukahluka kwe-Insulin Ukuphendula ngokulawulwa kwe-Myo-Inositol ku-Obese Polycystic Ovary Syndrome Iziguli. I-Gynecol Endocrinol. 2012; 28 (12): 969-973.
> Gerli S, Papaleo E, Ferrari A, Di Renzo GC. I-Randomized, i-Blum Double Blind Placebo-Controlled Trial: Imiphumela ye-Myo-Inositol ku-Umsebenzi we-Ovarian nama-Metabolic Factors kwabesifazane abane-PCOS. I-Europ Rev Med Pharmacol Sci . 2007; 11 (5): 347-354.
> I-Raffone E, i-Rizzo P, i-Benedetto V. I-insulin i-Agent Sensitiser Agents eyedwa kanye no-Co-Treatment nge-r-FSH yokukhishwa kwe-Ovulation ku-PCOS Abesifazane. I-Gynecol Endocrinol. 2010; 26 (4): 275-280.
> Galazis N, Galazi M, Atiomo W. D-Chiro-Inositol kanye Nokubaluleka Kwalo ku-Polycystic Ovary Syndrome: Ukubuyekezwa Okuhlelekile. I-Gynecol Endocrinol . 2011; 27 (4): 256-62
> Papaleo, E., Unfer, V., iBaillargeon, JP, et al. (2007). I-Myo-Inositol ezigulini ezine-Polycystic Ovary Syndrome: Indlela Yobuningi Yokukhishwa Kwe-Ovulation. I-Endocrinology ye-Gynecological, 23 (12): 700-703.
> D 'Anna R, Di Benedetto V, Rizzo P, et al. I-MYO-Inositol May Ingavimbele Isifo Sikashukela Sama-Gestational ku-PCOS Abesifazane. I-Gynecol Endocrinol. 2012; 28 (6): 440-442.
> Isabella R, Raffone E. Ingabe i-Ovary idinga i-D-Chiro-Inositol? J Ovarian Res. 2012 Meyi 15; 5 (1): 14.
> Dinicola S1, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. Isimiso seMyoinositol ne-D-Chiro-Inositol Eyinkimbinkimbi yokwelapha ye-Polycystic Ovary Syndrome. J Clin Pharmacol. 2014 Oct; 54 (10): 1079-92.
> I-Nordio M, i-Proietti E. Ukwelashwa Okuhlanganisiwe ne-Myoinositol ne-D-Chiro-Inositol Kunciphisa Ingozi Yezifo ZeMetabolic ku-PCOS Iziguli Ezithwala Amandla Okuqhathaniswa Nezinye Iziqhathaniswa neMyoinositol Supplementation Alone. I-Eur Rev Med Pharmacol Sci. 2012 Meyi; 16 (5): 575-81.
> Colazingari S, Treglia M, Najjar R, Bevilacqua A. Ukwelashwa Okuhlanganisiwe I-Myoinositol Plus D-Chiro-Inositol, Kunokuba D-Chiro-Inositol, Ikwazi Ukuthuthukisa Imiphumela ye-IVF: Imiphumela evela Ekulinganisweni Okulawulwa Ngalokhu. I-Arch Gynecol Obstet. 2013 Dec; 288 (6): 1405-11.