Ukudla Kwezokwelapha Okuvimbela Ukuvuvukala
I-limbrel yigama lomkhiqizo we-flavocoxid, isiguli "sokudla kwezokwelapha ze-botanical." Yenziwe ngokuhlanganiswa kwezimpande nezimpande ezivela ezitshalweni. Izitshalo zitshalo ziqukethe izinto ezibizwa ngokuthi i-flavonoids emgodini ophezulu ongenakukwazi ukudlala ngokujwayelekile.
Eminye yale flavonoids efanayo itholakala etizeni zokwelapha zesiShayina ezidakayo, ezisetshenziselwa ukwelashwa kwezimo ezihlukahlukene zezokwelapha zomlando omude.
Zitholakala nase-kale, i-cocoa, ama-apricot, i-cauliflower, i-soy nama-peanutes. Ku-Limbrel, i-flavonoids esemqoka yi-baicalin ne-catechin. Njengokudla kwezokwelapha, i-Limbrel ayitholakali emphakathini jikelele kodwa kunalokho kunqunyelwe iziguli ezizophathwa yizo izimo. Isibonakaliso samanje seLimbrel sisekulawulweni kwe-osteoarthritis .
Indlela Esebenza ngayo
Amakhokhethi e-flavonoid atholakalayo ku-Limbrel abonakala enezinto eziphikisana nokuvuvukala ngokuvimbela ama-enzyme abangela ukuvuvukala. La ma-enzyme, okuthiwa yi-COX (cyclooxygenase) ne-LOX (lipooxygenase) enza ama-molecule abangela ukuvuvukala nobuhlungu.
I-limbrel ivimbela ukukhiqizwa kwalezi zinkimbinkimbi futhi ngaleyo ndlela kunciphisa ukuvuvukala la ma-enzyme angabangela. Ayinayo ukuvimbela i-COX-2 ekhethiwe ukuthi ezinye izidakamizwa ze-arthritis zinayo. Ngezenzo ezimbili ku-COX no-LOX, kunemiphumela emibi emithanjeni yesisu, inhliziyo noma izinso.
Izinkomba
Isibonakaliso samanje sokumisa i-Limbrel singukuphathwa kwezidakamizwa zokudla kwezinqubo ze-osteoarthritis. Kungase kubekwe ukuba kube ne-osteoarthritis emincane. Akufanele kunikelwe kubantu abanomdlavuza we-flavocoxid noma i-flavonoids.
Uma uthola okweqile ekudleni okuvame ukuphakama kulezi zinto, ezifana netiye elihlaza, ushokoledi omnyama, iwayini elibomvu noma ama-nuts aseBrazil udokotela wakho anganquma ukungabonisi i-Limbrel.
Akukafundwanga ngokuqondile kubantu abangaphansi kweminyaka engu-18 noma abesifazane abakhulelwe noma abancelisayo, ngakho-ke akukhuthazwa kulabo bantu.
Isilinganiso
I-limbrel ne-Limbrel500 banikwa ngomlomo njengethebhulethi, kabili ngosuku. Kunezinhlobo ezimbili, ama-250 mg no-500 mg. Bobabili bane-50 mg ye-citrated zinc bislycinate. Umkhawulo wokugaya umuthi wokugulisa umuthi okufanele usetshenziswe ngaphansi kokuqondiswa udokotela.
Okuqhamuka uma udla imishanguzo
I-FDA ihlukanisa i-Limbrel njengokudla kwezokwelapha. Inikezwa njengemithi kadokotela, kodwa lokhu kudla kuye "kubonakala sengathi kuphephile" yi-FDA. Noma kunjalo, ukudla kwezokwelapha akunawo ukuhlolwa okusemthethweni okufanayo nokuhlolwa kokusebenza njengoba izidakamizwa kufanele zidlule ngaphambi kokuthi zibekwe emakethe. Baqhubeka nokubhekwa kokumaketha kokubambisana nemiphumela emibi.
I-limbrel ayitholakalanga ukuba nemiphumela emibi ibonwe ngemithi engaqinisekisiwe yokulwa nokuvuvukala (ama-NSAID), kufaka phakathi nezinkinga zokwakhiwa kwezilonda zesisu. I-limbrel ine nemiphumela emibi efana ne-placebo (iphilisi yeshukela). Ucwaningo luyitholile njengelusizo njenge-naproxen kodwa ngokuphepha okungcono kwamathumbu emathunjini, ama-renal nemiphumela yokuphefumula.
Amacala amane okulimala kwesibindi esivumelana neLimbrel abikiwe ekucwaningweni kuka-2010.
Izidakamizwa zezokwelapha ezibhekene nezithako zokudla
Amagama athi "ukudla kwezokwelapha" kanye "nesondlo sokudla" ahluke kumthethonqubo wabo yi-FDA.
Ukudla kwezokwelapha:
- inikeza ukwesekwa okunomsoco ngesifo noma isimo,
- futhi kuhloswe ukuthi kusetshenziswe ngaphansi kokuqondiswa udokotela.
Isihluthulelo ukuthi "ukudla kokudla" kuklanyelwe ukuphatha isifo esithile noma isimo (isb. Limbrel for arthritis), kanti "izithako zokudla" zenzelwe ukusekela umsebenzi ophilile wengxenye yomzimba (isib. Glucosamine for health cartilage).
Imithombo:
UMartel-Pelletier J, et al. "Umsebenzi wokwelashwa wama-inhibitors amabili we-5-LOX ne-COX, i-Selective and Non-Selective Non-Steroidal Anti-Inflammatory." I-Ann Rheum Dis. 2003 Jun; 62 (6): 501-9.
I-Leval X, et al. "Amathrendi amasha ku-Dual 5-LOX / COX Inhibition." I-Curr Med Chem. 2002 Meyi; 9 (9): 941-62.
Limbrel.com
N. Chalasani, R. Vuppalanchi, V. Navarro, R. Fontana, H. Bonkovsky, H. Barnhart, DE Kleiner, noJH Hoofnagle. "Ukulimala Okubi Kwebindi Ngenxa Ye-Flavocoxid (Limbrel), i-Medical Food ye-Osteoarthritis. Uchungechunge lwama-Case. "Ama-Annal of Medicine Internal 19 Juni 2012 (ivolumu 156, amakhasi 857-860).
Levy RM, Khokhlov A, Kopenkin S, Bart B, Ermolova T, Kantemirova R, Mazurov V, Bell M, Caldron P, Pillai L, Burnett BP. "Ukusebenza nokuphepha kwe-Flavocoxid, i-N ovel Therapeutic, eqhathaniswa ne-Naproxen: Isivivinyo Esilawulwa Ngokwe-Multicenter Elandelwayo Ezincwadini Ne-Osteoarthritis Ye-Knee." U-Adv Ther. 2010 Oct; 27 (10): 731-42. i-doi: 10.1007 / s12325-010-0064-z