Izinzuzo zezempilo, Ukusetshenziswa, Amathiphu nokuningi
Iyini i-Melatonin?
Ekhiqizwa ngokwemvelo emzimbeni, i-melatonin iyi-hormone esiza ukulawula imijikelezo yomzimba nokulala kwama-hormone ahlukahlukene emzimbeni. Yenziwe kusukela ku-amino acid tryptophan.
Umzimba ukhiqiza i-melatonin ngesikhathi sobumnyama (ukulungiselela ukulala) nokuvimbela ukukhiqiza ngesikhathi sokukhanya. Ngokusho kwabanye abaxhasi, ukuthatha i-melatonin ngesimo se-synthetic supplemental supplements kungasiza ekuthuthukiseni ukulala.
Ngomnyaka we-1970 nango-1980, ukucwaninga ngemiphumela ye-melatonin ekulele kwaholela ekusetshenzisweni okukhudlwana kwama-supplemental melatonin njengenye indlela yokwelapha ukuphazamiseka kokulala. Maphakathi nawo-1990, ukuthandwa kwe-melatonin ye-jet lag futhi izinkinga ezithile ezihlobene nobudala zakhula ngokuphawulekayo.
Ukusetshenziswa kwe-Melatonin
Eminye imithi, izithako ze-melatonin zisetshenziselwa ukulungisa umjikelezo womzimba wokulala futhi kuthiwa zizosiza ngalokhu okukhathazayo kwezempilo:
- I-Jet lag
- Ukungalali
- Ukuphazamiseka kokulala ngenxa yomsebenzi wokushintsha
- Ihlehlisiwe ukulala kwesigaba se-Sleep Stise Syndrome
- Ukuqwashisa okuhlobene nokuhlukunyezwa kwengqondo (ADHD), i-autism, i-cerebral palsy, kanye nobuphofu.
- Ukulala usizo emva kokuyeka imithi ye-benzodiazepine
- Ukunciphisa imiphumela emibi yokuyeka ukubhema
- Ukushona ngenxa yokusetshenziswa kwemithi (isib. Beta-blockers)
Abanye abaxhasayo bathi i-melatonin ingalwela ezinye izinhlobo zomdlavuza futhi iphinde inciphise ezinye imiphumela emibi ye-chemotherapy.
Ngaphezu kwalokho, kuthiwa i-melatonin iyasiza ngokuqwashisa okuhambisana nezimo ezithile ezifana nesifo se-Alzheimer, ukucindezeleka, nesifo schizophrenia.
Izinzuzo zezempilo zikaMelatonin
Nakhu ukuhlolisisa ukusetshenziswa kwe-melatonin eminye imithi kanye nezinzuzo zezempilo:
1) I-Jet Lag
Ukuhamba ngezinkathi zesikhathi kuphazamisa isigqi se-circadian.
Ubufakazi bokuqala bubonisa ukuthi izithako ze-melatonin zinganciphisa izimpawu ezithile ze-jet-lag, ikakhulukazi kubantu abahamba empumalanga kanye / noma bewela izindawo ezinhlanu noma ngaphezulu. I-Melatonin ingase ithuthukise ukuqapha phakathi nosuku, ukubambisana nokunyakaza, futhi kancane kancane, ukukhathala kwesikhashana.
Imiphumela emihle ibonakala iyenzeka uma izithako ze-melatonin ziqaliswa ngosuku lokuhamba futhi zithathwe ngesikhathi sokulala esifisa endaweni. Ngokuvamile kuthathwa izinsuku ezimbalwa.
Ezihlobene: 5 Izifo Zokwemvelo Zokugwema I-Jet Lag .
2) Ukushona
I-Melatonin ibonakala inganciphisi isikhathi esithathayo ukulala, kodwa kuphela ngamaminithi angu-12 (ngokusho kwesifundo esisodwa). Ucwaningo oluthile lubonisa ukuthi isikhathi esifanele ukuthatha izithako ze-melatonin liphakathi kwesigamu nehora namahora amabili ngaphambi kokulala okufunayo. Kunobunye ubufakazi obonisa ukuthi i-melatonin ingaba usizo kakhulu kubantu asebekhulile, mhlawumbe ngoba kungenzeka babe ne-melatonin encane emizimbeni yabo. Ucwaningo oluningi lube luncane futhi olufushane esikhathini eside, ucwaningo olungaphezulu luyadingeka.
Bheka izixazululo ezingu-14 zemvelo zokushaya ukushona .
3) Umsebenzi we-Shift
Nakuba umsebenzi wokusebenza ebusuku ubhidliza isigqi sangaphakathi, kukhona ubufakazi obuncane obusekela umbono wokuthi i-melatonin ingakwazi ukulungisa isimiso sokulala kubantu abasebenza ebusuku bese belala emini.
Akubonakali ukuthuthukisa ubuthongo ngemuva komsebenzi wokushintsha noma ukuthuthukisa ukuqapha ngesikhathi sokushintsha umsebenzi.
4) Izinkinga zokulala ezihlanganiswa nobuphofu
I-Melatonin ingathuthukisa ukuphazamiseka kokulala kubantu abangaboni.
5) Yehlisa isikhathi sokulala kwesifo se-Syndrome
I-Melatonin ihlolwe ngabantu abane-syndrome yesigaba sokulala esibambezelekile. Ucwaningo lubonisa ukuthi ukudla nsuku zonke kuze kube amasonto amane kungathuthukisa ukulala, ngokunciphisa isikhathi esidingekayo sokulala nokuphuthuma isikhathi sokulala. Kodwa-ke, kungakapheli unyaka owodwa wokuyeka izithako, ukubuyiselwa emaphethini okulala ngaphambi kokwelashwa kuye kwaphawulwa.
6) Izinkinga Zokulala Ezihambisana Nezinkinga Zokuthuthukiswa
Kuye kwaba nemibuzo eminingi yokuqala kanye nemibiko yesikhala ekusetshenzisweni kwe-melatonin ezinganeni ezinezinkinga ezibangelwa ubuthongo obunzima, njenge-autism spectrum disorders, ukukhubazeka kwesibindi, noma ukufa kwesifo. Ucwaningo oluqhutshwa kuze kube manje lubonisa ukuthi i-melatonin inganciphisa isikhathi sokulala nokude isikhathi sokulala. Noma kunjalo, imiphumela emibi kanye nokuphepha kokusetshenziswa kwe-long-term noma okujwayelekile kwe-melatonin ezinganeni aziwa.
Iya ekhasini 2 ukuze ufunde mayelana nokunye ukukhathazeka okuphepha ...
Amapulangwe
Yize ucwaningo luvame ukubheka ukusetshenziswa kwe-melatonin kuze kube izinyanga ezimbili, imiphumela emibi nokuphepha kokusetshenziswa isikhathi eside noma okujwayelekile kwezingxenye ze-melatonin aziwa. Abanye ochwepheshe bacabangela ukulinganisa okuvame ukutholakala ezincelweni ze-melatonin, ama-milligram angu-3 kuya ku-5, ukuba abe phezulu kakhulu futhi uthi ukuthi inani eliphakathi kuka-0.1 kuya ku-0.5 milligrams linengqondo.
Izithako ze-Melatonin akufanele zithathwe yizingane noma intsha, njengoba kunokukhathazeka okuthile ukuthi izithako ze-melatonin zingathinta ukuthuthukiswa kwe-gonadal. Amanani aphezulu we-melatonin angase abe nomthelela wokuvimbela ukuvuthwa. Abesifazane nabesifazane abakhulelwe nabahlengikazi abazama ukukhulelwa kufanele bagweme ukusebenzisa i-melatonin.
Imiphumela emibi ye-melatonin ingafaka ubuthongo, ikhanda, isizungu, amaphupho acacile, ukuguqulwa kwesikhashana esifushane, nokunciphisa okwesikhashana ukunakwa nokulinganisela. Abantu akufanele baqhube noma basebenzise imishini amahora amahlanu ngemuva kokuthatha i-melatonin. I-Melatonin ingabangela izidumbu zomzimba, isicashu, nokuhlanza, ukucindezela kwegazi okuphansi, futhi okungajwayelekile, ukucubungula noma i-paranoia.
I-Melatonin ingandisa ingozi yokuphuma kwegazi, ngakho akufanele isetshenziswe ngabantu abasebenzisa i-warfarin (i-Coumadin®) noma iminye imithi ephazamisa ukugaya igazi, noma abantu abanezinkinga zokuphuma kwegazi.
I-Melatonin ithonya ukukhiqizwa kwama-hormone.
Ukwanda kwesifuba sesifuba samadoda kanye nokubalwa kwesibalo sembewu kuye kwabikwa. I-Melatonin ingathinta futhi ushukela wegazi namazinga e-insulin.
I-Melatonin ingathonya ukusebenza komzimba. Akukwaziwa ukuthi kuzoba nomthelela kanjani kubantu abanezimo ezizimele ezifana ne- multiple sclerosis , i- psoriasis , isifo se-Crohn , isifo se- rheumatoid arthritis , i- lupus , nohlobo lwesifo sikashukela se-1.
Akufanele kuthathwe ngabamukeli bokufakelwa kabusha.
Izithako ze-Melatonin zingase zikhubekise izimpawu kubantu abanokucindezeleka, ngakho abantu abanokucindezeleka kufanele basebenzise kuphela i-melatonin ngaphansi kokuqondiswa komhlinzeki wezempilo. Kungase futhi kwandise ingozi yokubamba abantu abanenkinga yokuthungatha. I-Melatonin idilizwe isibindi, ngakho-ke abantu abanezifo zesibindi bangadinga ukugwema i-melatonin.
I-Melatonin ingase ihlanganyele izidakamizwa kanye nezithako ezifana nalezi:
- Imithi ephakeme yegazi
- Izidakamizwa ezivimbela amasosha omzimba, njenge-cyclosporine
- Imithi yokucindezeleka
- I-Corticosteroids (esetshenziselwa izimo ezivuthayo ezifana ne-arthritis)
- I-Benzodiazepines, njenge-diazepam nezinye izidakamizwa ezibangelwa ukudakwa
- Amakhambi abangela ukulala noma ukulala, njenge-kava kava ne- valerian
- I-wort ye-Herb John
Ukusebenzisa i-Melatonin yezeMpilo
Kubalulekile ukuqaphela ukuthi ukuzitholela isimo futhi ukugwema noma ukubambezela ukunakekelwa okujwayelekile kungaba nemiphumela emibi. Ungathola amathiphu ekusebenziseni izithako lapha , kepha uma ucabangela ukusetshenziswa kwe-melatonin nganoma iyiphi injongo, qiniseka ukuthi uthintane nomhlinzeki wakho wokunakekela oyinhloko kuqala.
Imithombo:
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I-Gringras P, i-Gamble C, i-Jones AP, ne-al; I-MENDS Iqembu Lokufunda. I-Melatonin yezinkinga zokulala ezinganeni ezinezinkinga ze-neurodevelopmental: isilingo esilawulwayo se-placebo esilawulwa ngokungahleliwe. BMJ. 2012 Nov 5; 345: e6664.
UJames M, u-Tremea MO, uJ Jones JS, uKrohmer JR. Ingabe i-melatonin ingathuthukisa ukujwayela ukushintshwa ebusuku? Am J Emerg Med 1998; 16: 367-70.
UJan, JE, Hamilton, D., Seward, N., Fast, DK, Freeman, RD, noLaudon, M. Ukuvivinya ngezidakamizwa zokukhishwa kwe-melatonin elawulwa yizinkinga ezinganeni ezinezinkinga zokujikeleza zokulala. J Pineal Res 2000; 29 (1): 34-39.
Nagtegaal JE, Laurant MW, Kerkhof GA, et al. Imiphumela ye-melatonin ngekhwalithi yokuphila kweziguli ezine-syndrome yesigaba sokulala esibambezelekile. J Psychosom Res 2000; 48: 45-50.
Standard Standard. "Melatonin" Mayoclinic.com. Ifinyelele ngo-Okthoba 3, 2007.
PDRHealth. "Melatonin" Ifinyelele ngo-Okthoba 3, 2007.
I-Rossignol, i-DA ne-Frye, i-RE Melatonin ku-autism izimbangela ze-spectrum: ukubuyekezwa okuhlelekile nokuhlaziywa kwe-meta. I-Dev.Med.Child Neurol. 2011; 53 (9): 783-792.
Sack RL, Brandes RW, Kendall AR, et al. Ukufakwa kwemigqa ye-circadian free-running by melatonin kubantu abayizimpumputhe. N Engl J Med 2000; 343: 1070-7.
Ukuziphendulela: Ulwazi oluqukethwe kule sayithi luhloswe ngezinjongo zemfundo kuphela futhi aluthathi iseluleko, ukuxilongwa noma ukwelashwa ngudokotela olayisensi. Akuhloselwe ukumboza zonke izinyathelo zokuqapha, ukusebenzisana kwezidakamizwa, izimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.