Imithi ebizwa ngokuthi i-mirogabalin ihlinzeka ngethemba lokuphumula komzimba ngemiphumela emibi kakhulu kunezinhlinzeko zokwelashwa zamanje ze- fibromyalgia (FMS) . Sekuseni kakhulu ukuze ukwazi ngokuqinisekile, noma kunjalo.
I-Mirogabalin yisidakamizwa sokuhlola ukuthi yilona ilungu lesithathu "lomndeni" wemithi ejwayelekile kumphakathi we-FMS. Ababelethi bayo yiNeurontin (gabapentin) noLyrica (pregabalin) , obizwa ngokuthi "indodana kaNeurontin."
I-Neurontin neLyrica yizo zonke izidakamizwa zokuhlukunyezwa ezitholakale ziphumelele ubuhlungu besifo sikashukela soshukela . I-Lyrica ngaleso sikhathi yayivunyelwe i-FDA ye-FMS ne-Neurontin ivame ukubekwe eceleni kwelebuli. Zibuye zisetshenziselwe ezinye izinhlobo zobuhlungu, kuhlanganise nobuhlungu bokuthunyelwa emva kokuhlinzwa kanye ne-neuralgia ye-postherpetic .
Kodwa-ke, i-Mirogabalin isetshenziswe ngokukhethekile ngengqondo ye-neuropathic ne-FMS.
Yeka ukuthi i-Mirogabalin isebenza kanjani
Ngokusho komkhiqizi wezidakamizwa waseJapan u-Daiichi Sankyo, i-mirogabalin ibopha iziteshi ze-calcium ebuchosheni, njengeLyrica ne-Neurontin. Kodwa-ke, i-mirogabalin kubikwa ukuthi ibopha ngokukhetha ngaphezu kweLyrica, okungenza kube nemiphumela emibi embalwa.
Njengamanje, imiphumela emibi ingaba yinkinga enkulu eLyrica, Neurontin, nakwezinye izidakamizwa ze-FMS. Eqinisweni, abantu abaningi bayeka ukuthatha lezi zidakamizwa ngenxa yabo. Uma izilindelwe zakuqala zibambe futhi i-mirogabalin inikeza ukuphumula kobuhlungu ngokunciphisa okuncane, kungaba yinto enkulu kubantu abanobujamo.
I-Mirogabalin nayo ikholelwa ukuthi ihlala isikhathi eside kuneLyrica, okusho ukuthi kungadingeka ukuthi kuthathwe kancane kancane. Ucwaningo lukaJanuwari wezi-2016 luphakamisa ukuthi umthamo wemihla ngemihla ungase ube ngcono ekunciphiseni imiphumela emibi.
I-Fibromyalgia ne-Neuropathy
I-Daiichi Sankyo okwamanje iqhuba isifundo somuntu onguyinkulungwane kwi-mirogabalin ye-FMS.
Lokho kuyisifundo esikhulu kakhulu (futhi esibiza kakhulu) sokuqala ekuqaleni kwenqubo, esibonisa ukuthi inkampani inethemba ngemiphumela.
Izifundo zezidakamizwa zivame ukuqhathanisa imithi ye-placebo, kodwa lo ubeka i-mirogabalin ikhanda kuya ekhanda ngokumelene neLyrica.
Ucwaningo olushicilelwe ngo-2014 lwasikisela ukuthi i-mirogabalin ibonise isithembiso njengendlela yokwelashwa kwesifo sikashukela se-peripheral neuropathy.
Ucwaningo oluningi oluthile lwalinganiselwa ukuthi i-mirogabalin ingaba nezikhathi ezingu-17 ezingaphezu kukaLyrica; Kodwa-ke, abanye abacwaningi baye bagxeka ukuklanywa kwalolu cwaningo.
Isilinganiso
Izilinganiso ezifanele ze-miragabalin azange zenziwe. Ucwaningo oluthola ukuthi i-potency engu-17 ekhulunywe ngenhla ilinganiselwa ukuthi umthamo kungenzeka ube ngu-17.5 mg noma uphansi, uma kuqhathaniswa nomgudu wansuku zonke we-Lyrica angu-150.
Izifundo ze-neuropathy zisebenzisa ama-15 mg, 20 mg, noma ama-30 mg.
Ubufakazi bokuqala bubonisa ukuthi imingcele ephansi ingadingeka kulabo abanezinkinga ezinengqondo ezinzima noma ezinzima.
Imiphumela emibi kanye nezixwayiso
Imiphumela emibi ingenzeka nanoma yimiphi imithi futhi uhla oluphelele lwazo ngokuvamile alukwazi kuze kube yilapho sebeye emakethe iminyaka embalwa.
Kuze kube manje, ucwaningo luye lwasikisela ukuthi i-mirogabalin ingaxhunyaniswa no:
- isiyezi
- ukulala
- ukulala ngezikhathi ezinde ngokungajwayelekile
- ikhanda
Ngabe I-Mirogabalin Eyokutholakala Ngini?
Ucwaningo lwezokwelapha yinqubo ephuthumayo kakhulu. Ngesivivinyo esikhulu sokuqala esuqale ngo-2015, futhi kufaka phakathi inani elikhulu labahlanganyeli, asikwazi ukulindela ukubona imiphumela mhlawumbe iminyaka embalwa.
Uma i-mirogabalin iqhubeka ukubonisa isithembiso futhi isicelo esisha seDrug ngaphambi kwe-FDA, kungathatha enye iminyaka embalwa ukuba ivunyiwe noma ilahlwe.
Ngakho-ke kuyakhuthaza ukwazi ukuthi ukwelashwa okunikeza ukuphumula kobuhlungu nemiphumela emibi kungase kube esikhathini esizayo, sidinga ukuqhubeka sifuna izindlela zokwelashwa zamanje ezingasisiza ukuba siphathe izimpawu.
> Imithombo:
> Izivivinyo Zomtholampilo zaseBoston. "Yini Ethembisayo Ngokuphathelene Ne-Mirogabalin? Ukuphawula komtholampilo kusifundo sethu esisha se-Fibromyalgia." Wonke Amalungelo Agodliwe.
> I-Calandre EP, i-Rico-Villademoros F, i-Slim M. Ukubuyekezwa kobuchwepheshe be-neurotherapeutics. 2016 Jul 7: 1-15. [I-Epub ngaphambi kokuphrinta] i-alpha2delta ligands, i-gabapentin, i-PGB ne-MGB: ukubuyekezwa kwemithi yabo yokwelashwa kanye nokusetshenziswa kokwelapha.
> Inkampani ye-Daiichi Sankyo, Limited. "U-Daiichi Sankyo umemezela iziguli zokuqala ngeziNhlelo eziMkhulu, eziMigodi kaZwelonke zeMigomo yesiFundazwe ye-MIrogabalin." Wonke Amalungelo Agodliwe.
> UHutmacher MM, et al. I-Journal yemithi yezokwelapha. 2016 Jan; 56 (1): 67-77. Ukulinganisa-ukuphendula ukuphendula okulinganiselwe ubuhlungu besilinganiso sezinsuku zansuku zonke, nokuzondeka nokungahlali kahle, kwe-mirogabalin (DS-5565) ezigulini ezinesifo sikashukela ozwakalayo ubuhlungu be-neuropathic.
> Izimvume ezintsha zeDrug. "Mirogabalin." Wonke Amalungelo Agodliwe.
> Vinik A, et al. Ukunakekelwa yisifo sikashukela. 2014 Dec; 37 (12): 3253-61. Ukusebenza nokuphepha kwe-mirogabalin (DS-5565) yokwelapha ubuhlungu besifo sikashukela obuhlungu ubuhlungu be-neuropathic: inhlolovo yesigaba sesi-2 esilawulwa ngokungahleliwe, ephindwe kabili-eyimpumputhe, esebenzayo.
> Yin OQ, et al. I-Journal yemithi yezokwelapha. 2016 Feb; 56 (2): 203-12. Imodeli ye-pharmacokinetic ye-population kanye nokulingiswa kokuhlola ukukhubazeka komonakalo we-renal kwi-pharmacokinetics ye-mirogabalin.