I-lymphoma ingumdlavuza wegazi ochaphazela i-lymphocytes, uhlobo lwe-white cell cell. Izinhlobo ezimbili eziyinhloko ze-lymphoma yi- Hodgkin's lymphoma non-Hodgkin's lymphoma, noma i-NHL. Nakuba i-lymphomas ivame ukuqala ema- lymph nodes , ingavela cishe noma ikuphi emzimbeni. Uma zivela ngaphandle kwe-lymph nodes, zibizwa nge-extranodal lymphomas.
I-bone eyinhloko i-lymphoma i- extranodal lymphoma engavamile . Uma i-lymphoma iqala ngaphandle kwe-lymph nodes, kuvame kakhulu ukuthi lesi sifo siqale emgqumeni wesisu kunasethambo.
Sibutsetelo
I-bone lymphoma eyinhloko yisimo esingavamile kakhulu lapho i- lymphoma iqala emathanjeni. Lesi simo sibangela amaphesenti angaba ngu-1 kuya kwangu-2 azo zonke izimo ze- non-Hodgkin lymphoma , enezibalo eziphakeme zamaphesenti angu-3 kuya kwangu-9 ezinganeni nasebancane. Amagciwane aqala kwenye indawo futhi asakaze emathanjeni ajwayelekile kakhulu kune-primary bone lymphoma.
Ubani Othintekayo ?
Amathambo e-primary primary lymphomas athinte kakhulu abantu abadala. Abesilisa cishe bangathinteka kunabesifazane. Iningi aliyona i-Hodgkin lymphomas ye-B-cell enkulu , lapho inani lamacala liphakama phakathi kweminyaka engama-45 no-60. Nokho, uma kuziwa ngaphansi komgogodla ku-sacrum noma umsila, i-bone lymphoma eyinhloko inekhulu isigameko eminyakeni yeshumi nambili.
Futhi amacala angavamile akhona ezinganeni ezineminyaka engu-12 ubudala.
Izimpawu
Abantu abaningi abathintekayo yi-primary lymphoma amathambo kuqala bazwa ubuhlungu emathanjeni abo. Ngokuvamile ubuhlungu bubonakala ngisho nokuphumula. Lokhu kungase kuqhubeke izinyanga ngaphambi kokuba kuvele ezinye izimpawu . Lapho i-lymphoma ikhula kakhulu, ingabangela ukuvuvukala kwesigungu futhi kunciphise ukunyakaza kwengalo noma umlenze.
Ezinye izimpawu ze-lymphoma ezifana nomkhuhlane kanye nokulahlekelwa isisindo akuvamile.
Uvivinyo
Ukucabangela ukuxilonga, ama-X-rays, neziketshezi zethambo , kusiza ukuthola i-bone lymphoma eyinhloko. Isisu sesithambo sibonisa ushintsho lwezici lapho kubonakala khona ithambo emzimbeni we-MRI noma we-CT. Kungaba khona iphethini lokudliwa kwamathambo ezindaweni ezithinteka yi-lymphoma.
Ukuze unqume uhlobo lwe-tumor, i-biopsy yethambo isenziwe. Lokhu kungenziwa ngokuhlinzwa, ngokuthatha ucezu oluncane lwethemba elihilelekile elihlolwe ukuhlolwa kwezinto ezincane. Ezinye izivivinyo zisiza ukucacisa ukuthi ngabe isisu siyasakazeka noma sinqunyelwe ithambo. I-PET / CT yesifuba, isisu nesifuba singasetshenziselwa ukunquma ukulingana komzimba we- lymph node nokutholakala kwezifo ezikude.
Izinhlobo
Ngokuvamile, i-primary bone lymphoma ayiyona i-Hodgkin lymphoma noma i-NHL. I-Hodgkin i- lymphoma yethambo ayincane kakhulu. Phakathi kwezinhlobo ezahlukene ze-NHL, ehlukanisa i-B-cell lymphoma enkulu noma i-DLBCL, iyona ejwayelekile kunazo zonke izifo zethambo lymphoma. Uhlobo lwe-lymphoma luqondisa izinqumo mayelana nendlela yokwelapha okungase ilandelwe.
Ukwelapha
Ngenxa yokuthi i-bone lymphoma eyinhloko ingavamile, isimiso esisodwa sezokwelapha esingahle singasungulwa. Izindlela zokwelashwa zamanje zivame ukwakhiwa kwe-chemotherapy emigqeni embalwa ehlangene ne- radiation therapy kuya ethambo.
Ukwelapha ngezimbalwa ezihlukahlukene, noma ukwelashwa kwe-multimodal, kuvamile, noma kunjalo, ukulandelana kwemisakazo kanye ne-chemotherapy kuyahlukahluka emibikweni enyathelisiwe. Izinga lokusinda lamathambo ayisisekelo lymphomas ngokuvamile lihle kunezinye izinhlobo ze-non-Hodgkin lymphoma.
IYunivesithi yaseMiami ibika amaphesenti angaphezu kuka-80 abantu abaphathwa nge-primary bone lymphoma abangenakho ukuqhubeka kwesifo sabo eminyakeni emine kamuva - bathola amaphesenti angama-83 okusinda-mahhala, noma i-PFS ekutadisheni iziguli ezingama-53. Akukho umehluko owawukhona phakathi kweziguli eziphathwe nge-chemotherapy noma i-chemotherapy ehlanganisiwe kanye nemisebe.
Kodwa-ke, kwakukhona umkhuba ekuthuthukiseni ama-PFS ngeziguli ezine-DLBCL eziphathwe nge-rituximab plus chemotherapy.
Isiphetho
Ngemuva kokwelashwa, ukuhlolwa kwe-PET / CT kungasiza kakhulu ukuhlola impendulo yokwelapha. Ucwaningo lwama-post-treatment lwe-imaging olukhethwa yi-PET / CT scan, olusiza ukuhlukanisa izifo eziqhubekayo ezivela ku-fibrosis. Iziguli kufanele zihlolwe futhi ngokuphindaphinda kwesikhathi eside. I-bone lymphoma inezinga eliphansi lokuphindaphinda kwendawo futhi ngokuvamile libuyele ezindaweni ezikude ukusuka kwesifo sokuqala.
Imithombo
Ukuze uthole okwengeziwe ngalesi sihloko, hlola imithombo elandelayo:
Alencar A, Pitcher D, Byrne G, et al. I-bone primary lymphoma - isipiliyoni se-University of Miami. I-leukemia ne-Lymphoma . 2010; 41 (1): 39-49.
Thornton E, Krajewski KM, O'Regan KN et al. Ukucabangela izici zamathumba eziyisisekelo nambili ezibulalayo ze-sacrum. I-British Journal ye-Radiology . 2012; 85 (1011): 279-284.
Ukucabangela Amathumba Amathumba Ne-Tumor-Like Izilonda: Izindlela Nezicelo; A. UMark Davies, uMurali Sundaram, uSteven J. James. I-Springer Science & Business Media, 2009.
Izimiso Nezenzo Zokushisa I-Oncology 4th Ed. Abahleli: UCarlos A Perez, uLuther W Brady, u-Edward C Halperin noRupert K Schmidt-Ullrich. ULippincott Williams & Wilkins, ngo-2003.
I-Beal K, Allen L, Yahalom J. Primary Bone Lymphoma: Imiphumela yokwelapha kanye nezici zokubikezela ngeziguli ezingama-82 ezilandelwayo isikhathi eside. I-Cancer , ngo-2006; 106 (12).
U-O'Connor AR, uBirchall JD, u-O'Connor SR et al. Inani le-99mTc-MDP bone scintigraphy ku-staging primary lymphoma yamathambo. I-Nuclear Medicine Communications. 2007; 28 (7): 529-31.
I-Swerdlow SH, i-Campo E, i-Harris NL, ne-al, eds. I-WHO Ukufakwa Kwezingculazi Ze-Haematopoietic and Lymphoid Tissues. I-4th ed. I-Geneva, eSwitzerland: I-IARC Press; 2008.