Ama-salicylates Ahlukaniswa njenge-NSAID
Ukukhuluma ngamakhemikhali, i-salicylates yile usawoti noma i-ester ka-salicylic acid. Abaningi bethu bayazi ukuthi i- aspirin itholakala ku-salicylic acid. I-aspirin iyamakhemikhali eyaziwayo njenge-acetylsalicylic acid. Ama-salicylates ahlukaniswe ngamaqembu amabili, acetylated and nonacetylated. Ngenkathi i-aspirin i-acetylated, izibonelo zama-salicylate ezingenakulinganiswa zifaka i-Disalcid (salsalate), i-Trilisate (i-choline magnesium trisalicylate), ne-Pepto-Bismol (i-bismuth subsalicylate).
Omunye, obizwa nge-Dolobid (diflunisal), awusatholakali e-US.
Indlela uSalicyates Eyasetshenziswa ngayo
Kutholakale ngokwemvelo ezitshalweni ezithile, njenge-white willow bark kanye namaqabunga ebusikabusika, kwakukholelwa ukuthi i-salicylates inomthelela wokuzivikela ngokumelene nezinambuzane nezifo zezitshalo. Ngo-1860, i-salicylic acid yayikhiqizwa ngamakhemikhali eholela ekusetshenzisweni okubanzi. Ngokwemithi, i-salicylic acid ine-analgesic (ukukhululeka ubuhlungu), izakhiwo eziphikisayo neziphikisayo. Futhi, ngoba kunganciphisa ubuhlungu kanye nokunciphisa ukuvuvukala nomkhuhlane, i-salicylic acid ibonakala sengathi i-Trifecta yemithi. Kodwa-ke, emithonjeni edingekayo ukwenza impendulo, i-salicylic acid ingabangela izinkinga zomzimba. Uma kusetshenziselwa amanani amakhulu, okukhulu kunalokho okushiwo umphumela wokwelapha, i-salicylic acid ingaba yingozi. Ukwengeza, abanye abantu bangase babe nomzimba we-salicylic acid. Ngaphandle kokusetshenziswa kwalo kwezokwelapha, ama-salicylates asetshenziselwa ukudla okulondolozwayo, ezindaweni zokuvimbela izifo, futhi abe nezinye izindawo ezisiza ukuvimbela ukukhula kwebhaktheriya, ukubulala ukhunta, nokuqothula isikhumba esifile (i-keratolytic, njengeKerasol).
Izingozi zomzimba nezingozi zenhliziyo ezihambisana nama-Salicylates
Ngokungafani ne-aspirin, evimbela ukuhlanganiswa kweplatelet futhi ngenxa yalokho kwandisa ingozi yokugaya, ama-compounds angenakucatshangelwayo anezimpikiswano ezincane kumaplatelet. Ngenxa yalokho, bancane amathuba okubangela ukuphuma kwegazi noma izilonda eziphaphalayo emithini edingekayo ukunciphisa ukuvuvukala nobuhlungu be-arthritis.
Ngakolunye uhlangothi, okungenani uma kuqhathaniswa ne-aspirin ye-dose ephansi, azikho izifundo zokusekela ukuthi ama-salicylate angenayo i-caricoprotective ayikho. Eqinisweni, njengazo zonke ezinye i- NSAID (izidakamizwa ezingavumeli ukuvuvukala) , ukusebenzisa kwazo kungabangela ingozi eyingozi yokwenzeka kwe-heart disease, njenge-heart attack.
Ngokwesazi se-rheumatologist, uScott J. Zashin, MD, "Kungakhathaliseki ukuthi i-aspirin ye-high-dose ephezulu noma i-aspirin ephezulu ayizange isetshenziswe yini. Ngaphezu kwalokho, ngolwazi lwami, akukho zifundo ezishicilelwe eziqhathaniswa nokusebenza kahle noma ukuphepha kwamathunjini ye-salicylate engacacisiwe kanye ne- COX-2 inhibitors . "
Izifundo ezingatholakala ezithinta ama-salicylate zivame ukudala. Ucwaningo olwanyatheliswa kuyi-Journal of Rheumatology luqhathanise ukuphumelela kwe-salsalate (i-salicylate engahlosiwe) ku- Voltaren (diclofenac) . Kwaqedelwa ukuthi ukusatshalaliswa kanye ne-diclofenac kwakuphumelela ngendlela efanayo futhi ukuthi ukusatshalaliswa kungabhekwa njengenye indlela kwezinye i-NSAID.
Esinye isifundo, esaphinde sanyatheliswa kuyi-Journal of Rheumatology, sihlolisise umphumela weminyaka yobudala be-salicylate inyosi kubantu asebekhulile abane- rheumatoid arthritis . Naphezu kokuthatha isilinganiso esincane sama salicylate kuneqembu elincane labantu esifundweni, leli qembu elikhulile laxhunyaniswa nokwanda kokwephuza utshwala.
UDkt. Zashin waqhubeka, "Ngokusekelwe kokuhlangenwe nakho kwami, ama-NSAID yendabuko kanye nama-inhibitors we-COX-2, ngokuvamile, ama-agent asebenzayo kangcono ukuphatha ubuhlungu nokuvuvukala kwe-arthritis. Lokhu kuthiwa, ukuvivinywa kwe-salicylate engacabangi akuyona into engenangqondo ezigulini ezikhethiwe ezinengozini yokwanda kwegazi noma izilonda. "
Izwi elivela
Eminyakeni eyizinkulungwane edlule, i-salicylic acid noma i-aspirin yiyisisetshenziswa esiyinhloko esasetshenziswa ukuphatha ubuhlungu be-arthritis. Ukuthi kwakubonakala ukunciphisa ukuvuvukala kwakuyisibhonasi ngaleso sikhathi. Manje, kunezidakamizwa eziningi ezivela kuzo ongakhetha kuzo. Ngokuvamile becatshangwa ukuthi iphephile, futhi engabizi ngokuqhathanisa nezinye izidakamizwa, i-salicylates yindlela okumele ihlolwe odokotela neziguli.
Kunengqondo ngawe nodokotela wakho ukucabangela umlando wakho wezokwelapha (isib. Izilonda, isifo senhliziyo) uma ukhetha phakathi kokukhethwa kwezidakamizwa.
> Imithombo:
> Bombardier C. et al. I-Salsalate, i-Salicylate engenziwanga kahle, Isebenza njenge-Efficacious njenge-Diclofenac ezigulini ezine-Arthritis ye-Rheumatoid. I-Salsalate-Diclofenac Study Group. Journal of Rheumatology. 1995. Ngo-Ephreli; 22 (4): 617-24.
> Grigor RR et al. I-Salicylate Inyosi Kubantu Abagulayo Abadala Abaphethe I-Rheumatoid Arthritis. Journal of Rheumatology 1987. Feb; 14 (1): 60-66.
> Salicylates. Drugs.com.