Ngaphambi kokuba siqale, ngifuna ukucindezela ukuthi kulabo abanesithakazelo kulo lonke indaba yokwelashwa kwesifo socansi besifazane , lesi sihloko mayelana nesipaki se-testosterone kufanele sifundwe ngaphakathi kokuqukethwe kwamanye ama-athikili amabili engibhalile : I- viagra yabesifazane I-pilgrimage ye- sex flibanserin entsha-kodwa engavunyelwe . Ngokucacile, i-testosterone patch imelela isiteji esiphakathi salesi wesifazane sokuhlukumeza ngokobulili: indlela eyazama emva kokuthi i-Pfizer iqede ukuxosha i-Viagra kubantu besifazane nangaphambi kokuthuthukiswa kwe-flibanserin, isidakamizwa sabantu besifazane esivumelana ne-neurotransmitter.
Izifundo Ngokwehluleka Kwezocansi Kwabesifazane
Ukuziphendulela kwemikhuba yonke yokuzama ukwelashwa kwemiphumela yokuhlukumeza ngokobulili kwabesifazane emuva kwe-1999 isihloko esashicilelwe ku- JAMA esivame ukubizwa ngokuthi "43-31". Abacwaningi abavela kulolu cwaningo bakhombisa ukuthi abesifazane abangaphezu kuka-4 kwabangu-10 (amaphesenti angu-43) banezinkinga zobulili uma kuqhathaniswa namaphesenti angu-31 wamadoda. Lolu cwaningo lwabeka ukuthi yini eqhubekayo yokugcoba kuzo zonke izimpikiswano mayelana nokuphathwa kokungasebenzi komzimba ngokobulili; i-rub rub ephethe izinkampani ezenza imithi kanye nochwepheshe abaningi bezocansi ngakolunye uhlangothi, futhi abagxekayo bathi ukugulisa isimo socansi njengesinye isibonelo sokuthi "isifo sengqondo" ngakolunye uhlangothi.
Ngo-June 21, 2004, iProtector & Gamble isicelo se-FDA imvume ye-system yayo entsha ye-testosterone (i-jargonese ye-testosterone patch), i-Intrinsa. I-Intrinsa yayihloswe ngokuthi:
Ukwelashwa kwesifo socansi olungenabuzenzisi ngokobulili emaphoyiseni abahlinzayo abesilisa abathola ukwelashwa kwe-estrogen ehambisanayo. Ukukhathazeka kwesifiso sobulili (Hyperactive desire disorder) (HSDD) ukusilela okuqhubekayo noma okungajwayelekile noma ukungabikho kwemicabango ngokocansi, ukucabanga, kanye / noma isifiso sokwamukela umsebenzi wezocansi, okubangela ukucindezeleka komuntu siqu noma ubunzima bomuntu siqu. Isifiso sobulili esifanele singase sihlotshaniswe nomsebenzi ophansi wocansi, izinkinga zokuvusa ucansi noma ubunzima be-orgasm.
Njengoba kuphawulwe ekuhloleni kwami okudlule kokungasebenzi komzimba ngokocansi , i-HSDD yikhathi esinqunyiwe. Namuhla, i-DSM-5 ikhuluma ngokuthi "ukuvuthwa komuntu wesifazane / ukukhathazeka kwesithakazelo" okuhlanganisa izinkinga zesifiso futhi ivuke emkhakheni owodwa wezokwelapha.
Imiphumela evela ku-P & G ye-Phase 3 yokuhlolwa kwemitholampilo iphakamisa ukuthi kulaba besifazane abanemicimbi emibili yobulili ngenyanga emibili kuya kwezingu-3, ukuphathwa kwama-300 μg (kodwa akukho 150 μg noma 450 μg) kuhlanganiswe nomcimbi owodwa wokwanelisa ngokocansi ngenyanga.
Ngenxa yezizathu ezimbili ezicacile, i-FDA yenqabe ukuvuma i-Intrinsa. Okokuqala, le miphumela ayikho emtholampilo. Kubantu asebevele benesidingo esivamile futhi esanelisayo , i-patch testosterone ikwandisa inani lemicimbi eyanelisa ngokocansi eyodwa ngenyanga! Okwesibili, ngenxa yalesi sigameko esisodwa esanelisayo ngokocansi, abesifazane abanesisu sokuhlinzwa esikhathini esithile abavele besithatha i-estrogen bazovezwa kwenye i-hormone, i-testosterone eyingozi. Ake ngichaze.
Phakathi nesikhathi uP & G afaka isicelo sokwamukelwa kwe-patch yayo ye-testosterone, wonke umuntu wayephuma ngemiphumela evela emisebenzini ye-Women's Health Initiative ehlola ukuxhaswa kwe-hormone. Ngaleso sikhathi, imiphumela evela kulezi zifundo iphakamisa ukuphathwa kwe-estrogen kanye ne-progesterone kwabesifazane emva kwe-hysterectomy kwandisa ingozi yemicimbi ye-cerebrovascular (cabanga ukushaywa umoya), izenzakalo ze-cardiovascular kanye nomdlavuza webele. I-FDA iphetha ngokuthi ngaphandle kokuqhubeka nokutadisha isikhathi eside, kungase kube yingozi ukunikeza abesifazane be-postmenopausal testosterone namanye ama-hormone. Ngokuphawula, ukuhlolwa kwangempela kwe-P & G kuhlolwe ukufaka isilwane se-testosterone kwabathintekayo kumaviki angu-52 kuningi.
Ngenxa yokuhlushwa kuka-FDA, i-P & G yabona ukungabi nalutho kokuxoshwa kwenkinga futhi yehla i-Intrinsa.
Ekubukekeni, kusobala ukuthi i-P & G ithemba ukuthi odokotela babeyobeka isigqebhezana se-testosterone sokusetshenziswa kwelebuli-ikakhulukazi, kwabesifazane ngaphandle kwalabo abaye babhekana nokuqeda ukuhlinzwa kwamamenyu. Ngenxa yokuntuleka kokutadisha isikhathi eside, noma kunjalo, i-FDA yahlukunyezwa yilokho kungenzeka.
Kukhona nezinye iziphumo zokucwaninga ezibuza ukuthi kungenzeka ukuthi i-testosterone iphumelele kanjani njengokungenelela kubantu abanesifo socansi / ukukhathazeka kwesidakamizwa. Okokuqala, asikho ubufakazi bokusebenza okuphansi kwe-androgen kwabesifazane abanezinkinga zokuhlukunyezwa ngokocansi. Okwesibili, nakuba singakwazi ukulinganisa i-intracrine noma ama-intracellular testosterone amazinga, asikwazi ukukala amazinga we-testosterone ohlelweni lwezinzwa zomphakathi.
Amazinga e-Testosterone ohlelweni lwezinzwa zomphakathi cishe anethonya elikhulu ekuvusweni nasekufisweni.
Ingabe Abesifazane Badinga Testosterone Eningi?
Ngamanye amazwi, asikwazi ukuthi ama-testosterone amazinga ebuchosheni nomgogodla walabo abanesisindo somzimba wesifazane ocansini akwanele ngokwanele ukuthi badinga ukufaka isilwane esiphezulu se-testosterone, ukuqala. Okwesithathu, ngisho nasezigayini ze-testosterone kanye nama-patches okwenziwe ukuphatha abantu, asikwazi ukuthi ubufakazi obuningi buyitholile kanjani ngaleyo ndlela ukwenza umthamo we-testosterone ukwengezela okuningi ngokuphathelene.
Kodwa nansi into. Kwabesifazane abaningi, ukufinyelela ku-testosterone ngenye indlela kuyenzeka. Isibonelo, abesifazane abanesifo sokuvusa / isithakazelo sezesondo zocansi besifazane bangasikelwa ama-gel testosterone kanye nama-patches off-ilebuli (ukuthatha imithi yamadoda). Izithako ze-testosterone nazo zingena kumafomu e-naturopathic angathengwa nge-intanethi. Okokugcina, kwamanye amazwe, i-testosterone ngezinye izikhathi inikezwa kwabesifazane abanokukhubazeka ngokobulili besifazane.
Ngakho-ke kuzo zonke, kusekhona izindlela zokwenza izandla zakho ku-testosterone ukuphatha ukungasebenzi komzimba wesifazane ; Nokho, sinikezwe lokho esikuziyo, mhlawumbe umqondo omuhle wokukhipha izinto. Ukucwaninga akubonisi inzuzo yangempela yomtholampilo we-testosterone supplementation kwabesifazane abanezinkinga zokuhlukunyezwa ngokocansi, kanye nathi asazi ukuthi amazinga e-testosterone awanalo yini abesifazane ababenokukhubazeka ngokocansi ekuqaleni. Futhi-ke, i-testosterone iyi-hormone, futhi ama-hormone aziwayo ukuthi angaba nomphumela omubi ongase abe nomthelela onjengoba uhlangothi, ama-blood clots, umdlavuza nokunye okunye.
> Imithombo:
> Isihloko > esibizwa nge "Testosterone therapy yokunciphisa i-libido kwabesifazane" nguR Basson eshicilelwe ku-Advances Therapeutic in Endocrinology kanye ne-Metabolism eyashicilelwa ngo-2010. Yatholakala ngo-3/3/3/5.
> Isihloko > esibizwa ngokuthi "I-Pinking of Viagra: Imithi Yezokwelapha Ukuzama Ukudala Imithi Yezocansi Kwabesifazane" kanye noHeather Hartley eyanyatheliswa ngo-2006 ngo-2006.