I-Pill Pill ye-Flibanserin ishukunyiswe kuDrama
Kwababhikishi bayo, i-flibanserin, iphilisi elibomvu elibhekene ne-libido yowesifazane futhi elenziwe yi-Sprout Pharmaceuticals, liyisibonelo esithile sesifo sengqondo. Izifo ukukhuluma zibhekisela emisebenzini yezinkampani ezenza imithi kanye nabanye "ukugulisa" izici zesimo somuntu ukuze benze i-buck. Isibonelo, i-halitosis noma ukuphefumula okubi kwaba yisimo esidinga ukwelashwa ngemuva kokuba uListerine yakhelwe "ukuphatha".
Kodwa-ke, kubasekeli bayo, ukukhathazeka ngokobulili / ukuvuthwa kwesisu kuyisifo sangempela, futhi i-flibanserin ingasiza. Laba baxhasi babhekisela ukucindezeleka okubangelwa ukushayisana kocansi okuncipha noma okungekho.
Kuyini Ukuthandana Ngokobulili / I-Arousal Disorder?
Intshisekelo yocansi / isifo socansi isho ukunciphisa noma ukungabikho kwesithakazelo socansi owesifazane ohlala ezinyangeni ezingu-6 noma ngaphezulu futhi kubangela ukucindezeleka noma ubunzima bomuntu siqu. Ngaphezu kwalokho, ukungabi nandaba okunjalo akubangeli esinye isifo (cabanga ngesifo sikashukela noma ukucindezeleka) noma izidakamizwa (cabanga ngokucindezeleka). Kubalulekile ukuthi ukulahlekelwa kwesifiso sobulili kubangela ukucindezeleka noma ubunzima ngoba, ngaphandle kwalokho, akuyona inkinga ngempela. Emva kwakho konke, abantu abaningi banokungathandi ukuhlala ocansini isikhathi eside esingazibangeli izinkinga zomuntu siqu, futhi lokhu kuhle.
Abacwaningi bafakazela ukuthi ukukhathazeka ngokobulili / ukuvuthwa kwesisu kuhilela ukucubungula kobuchopho obuningi bokulawula ukubuyekezwa komvuzo.
Ngokucacile, lesi simo sithinta izindlela ze-frontostriatal kanye nokuhlola kwe-neuronal ye-insula, i-amygdala, i-hypothalamus ne-ventral striatum. Kulabo besifazane abanesithakazelo esinjalo socansi kanye nezindaba zokuvusa, isisusa socansi nokuzijabulisa kuthinteka kakhulu. Okuphawulayo, ukuphazamiseka kokunciphisa imivuzo kwezinye izinkinga zezifo zengqondo kuhlanganise nokucindezeleka, isifo sokuhlukunyezwa kwezidakamizwa, ukucindezeleka, ukukhathazeka kokudla nezinye izifo zobulili.
Ngokuthakazelisayo, abacwaningi bathole ushintsho kuMRI esebenzayo ekhombisa ukuhlukunyezwa kwama-macrocircuit okubangelwa ukukhathazeka ngokobulili / ukukhushulwa kwesifazane. Ngokwesibonelo, abesifazane bathola ukuthi lo mbukiso ubonisa ukusebenza okungavamile ezindaweni ezibucayi ze-cortical kanye ne-bereatal.
UFlibanserin Usebenza Kanjani?
Kunzima kakhulu (akunakwenzeka) ososayensi ukukala amazinga athile we-neurotransmitter ezingxenyeni ezahlukene zobuchopho. Kodwa-ke, ngokusebenzisa amasu we-microdialysis nama-node ngaphakathi kwamanethiwekhi omcholo, abacwaningi basho ukuthi u-flibanserin ukwandisa ukukhululwa kokubili kwe-dopamine ne-norepinephrin futhi kunciphisa ukukhululwa kwe-serotonin kwabesifazane abanesithakazelo socansi nesifiso esinciphise. Ngokuqondile, i-flibanserin ingahlukanisa phakathi kwe-receptors ye-serotonin futhi ivuse i-serotonin 5HT1A receptors ngenkathi ivimbela i-serotonin 5HT2A receptors ku-prefrontal cortex ngaleyo ndlela ikhulisa ukukhululwa kwe-dopamine ne-norepinephrine engezansi. Ngokusobala, lezi zinto ezihlangene ze-neurotransmitter zisiza kangcono ukulawula ukucubungula umvuzo nokwandisa i-libido yesifazane.
Ngokuyinhloko, i-flibanserin isebenza kuma-neurotransmitters, hhayi ama-hormone. Nakuba ama-hormone aphumelele ekuqinisekiseni i-libido, imiphumela emibi yenza kube yingozi kakhulu njengokwelashwa.
Ngaphezu kwalokho, i-flibanserin ayiyona "i-Viagra yowesifazane." I-Viagra isebenza ngokukhuphuka kwegazi kuya ezifweni zobulili ngokusebenzisa indlela ehluke ngokuphelele futhi kuthinta indawo yesenzo ehlukile (ukuhlukumeza ngokumelene nobuchopho).
Imiphumela evela ezivivinyweni ezimbili zomtholampilo ezibizwa ngokuthi i-BEGONIA ne-DAISY (ah, amagama ezimbali ... ukuthi kuhle kangakanani!) Asikisela ukuthi i-flibanserin ingakwazi ukwandisa i-libido yesifazane. Okuhlanganisiwe, lezi zivivinyo ezilawulwe ngokungahleliwe kanye ne-placebo zihlolisise abesifazane abangama-3548 abanesithakazelo socansi nesifo sokuvusa. Ngemuva kwamaviki angu-24 wokunakekelwa kwansuku zonke nge-100 mg flibanserin, okwanelisayo izenzakalo zocansi , isifiso socansi , nokucindezeleka okubangelwa isifiso sobulili obuphansi babalwa ngokusebenzisa imibuzo ehlukahlukene (subjective).
Abacwaningi baphawula ukuthi kubahlanganyeli abathatha i-flibanserin-uma kuqhathaniswa nalabo abathwala indawo-kukhona ukukhuphuka kokuhlangana okuningana okwanelisayo ngokobulili kanye nezinga lesifiso socansi nokunciphisa ukucindezeleka okubangelwa isifiso sobulili esifanele.
Izenzakalo ezimbi kakhulu kulezi zivivinyo zenzeke ngaphansi kwamaphesenti angaphansi kwabahlanganyeli, futhi akukho nenye yalezi zigameko ezinkulu ezibangelwa ukwelashwa kwe-flibanserin ngokwayo. Imiphumela engathí sina engathí sina yayihlanganisa isizungu, isicashu, ukukhathala nokulala (okuvame kakhulu).
Olunye uhlolo olulawulwe ngokungahleliwe nolwakhelwe nge-placebo olubizwa ngokuthi i-SNOWDROP (Ngibona iphethini, lapha ... elinye igama lombali!), Lihlolisise abesifazane abangu-949 be-postmenopausal abanesifiso sobulili / isisindo se-sex (i-DSM-IV- I-TR eguqulwe kusukela kwisithakazelo socansi / ukuphazamiseka kocansi ku-DSM-5). Ngokufana nezinye izilingo, imiphumela ibonisa ukuthi i-flibanserin ithuthukisa isifiso sobulili, izenzakalo eziningana ezanelisayo zocansi nokunciphisa ukucindezeleka ngokobulili konke ngenkathi kubangela imiphumela embalwa emibi. Ngokuyinhloko, amaphesenti angu-37.6 abesifazane abesilisa abangamaphesenti angama-28.0 abamba ama-flibanserin nabakwa-placebo babika izenzakalo zocansi ezanelisayo.
Nakuba kwezinye zalezi zicwaningi abacwaningi bazama ukufaka abahlanganyeli abathatha imishanguzo yokucindezeleka, ama-antihypertensives, ama-triptans nezinye izici ze-antifungals, ukulinganiselwa okuyinhloko kwalezi zifundo kuyisibonelo sokwethenjelwa. Ngamanye amazwi, ngoba izinkinga zokuvusa ngokocansi nesifiso zigcwele futhi zithinta zonke izinhlobo zabesifazane, kwakunzima ukuhlola ukuthi ngabe i-flibanserin isebenza kuwo wonke umuntu.
Ekhuluma ngokukhathazeka mayelana nokuphepha nokusebenza, i-FDA yenqabe ukuvumela u-flibanserin-ukulahlwa okuphindwe kabili umenzi wakhe, i-Sprout Pharmaceuticals, kanye nabanye abhekana nayo. Ngombono wezokwelashwa, ngizizwela ngokukhathazeka kwe-FDA. Ngempela, amathuluzi e-flibanserin anama-neurotransmitter amaningana futhi ecabangela ukuthi abaningi besifazane abazothatha lesi sidakamizwa nabo bayothatha ezinye izidakamizwa eziqhubeka nokushintsha amazinga e-neurotransmitter - njengama-antidepressants kanye ne-anxiolytics - kungcono ukuthatha isinqumo sokuqapha.
Isiphetho
Abantu abaningi abaqondi kahle ukuthi bacabangani nge-flibanserin. Ngakolunye uhlangothi, abantu abaningi basolwa ngezinkampani ezenza imithi kanye nezinhloso zabo futhi babikezela ukuthi uma kuvunyelwe, i-flibanserin ingadluliselwa ngaphezu kwabesifazane abathile abanjengobo abangenaso ukucindezeleka okuhlobene nokuhlupheka kwesifiso sobulili noma ukuvusa. Encwadini ehlobene, yonke into ngokumaketha kwe-Sprout ye-flibanserin imemeza ukukhwabanisa kufaka phakathi umbala wepilisi omnyama kanye nokuhlolwa kwemitholampilo ye-pillow. Ngakolunye uhlangothi, kunzima ukuqonda imiphumela ye-flibanserin ngaphandle uma ungowesifazane osebenzisa lesi sidakamizwa.
Imithombo:
Isihloko esithi "Ukusebenza nokuphepha kwe-flibanserin kubesifazane be-postmenopausal abane-hypoactive disorder disorder: imiphumela yesilingo se-SNOWDROP" nguJA Simon nabambhali ababhaliwe eshicilelwe esikhathini sokunqamuka kwesikhathi: I-Journal ye-North American Menopause Society eyashicilelwe ngo-2013.
Isihloko esithi "Indlela yokusebenza ye-flibanserin, i-serotonin multi-functional agonist ne-antagonist (MSAA), e-hypoactive isifiso sesifo socansi" ngu-SM Stahl eshicilelwe ku- CNS Spectrum ngo-2015.
Isihloko esithi "Ukwandisa amathuba okuphatha ukwelashwa kwesifiso sobulili obungathí sina (HSDD): isimo sokuthuthukiswa kwe-flibanserin" nguJ Thorp, Jr, nabobhali be- BJOG eshicilelwe ngo-2014.