Odokotela abaningi basebenzisa ukweluleka ukubuka ukuthi udla inyama kaningi, amaqanda, kanye nemikhiqizo yobisi ephezulu ngenxa yamazinga aphezulu amafutha agcwele kanye ne-cholesterol ayenayo. Ukusebenzisa amafutha agcwele kungakhuphula amazinga we-low-density lipoprotein ( LDL ) cholesterol, i-cholesterol "embi" kanye nohlobo olubandakanya ukwandisa ingozi yomzimba wesifo senhliziyo kanye nemiphumela yaso, njenge-heart attack and stroke.
Kodwa izinga lokuxhumana phakathi kwamafutha okudla kanye ne-cholesterol nesifo senhliziyo kusanda kubuzwa. Namuhla, siyazi ukuthi iningi le-cholesterol likhiqizwa yisibindi kanti kuphela amaphesenti angu-15 kuya kwangu-20 avela ekudleni kwakho.
Lokhu okutholakele akuyona ilayisense yokudla nge-bacon, amaqanda, kanye ne-toast buttered. Ochwepheshe basakancoma ukuthi udle lokhu kudla ngokulinganisela. Nakuba lezi zokudla zingase zingakhulisi i-cholesterol yakho njengoba kucatshangwa ngaphambili, zihlukumeza impilo yakho yempilo ngegazi ngendlela ehlukile.
Izifundo zithole ukuxhumana okuqondile phakathi kwemikhiqizo yamakhemikhali eyenziwa emathunjini lapho lezi zokudla-ezivamile ekudleni kwe-Western-zidliwa futhi kwenzeka ukuhlaselwa kwenhliziyo, ukushaywa yisifo senhliziyo, ukuhluleka kwenhliziyo nokufa, imiphumela embi emibi yesifo senhliziyo .
Ukugaya Kuyisici
Amathumbu ethu aqhuma ngamabhaktheriya asebenza njengesihlungi sokungcola kwethu okukhulu kwemvelo-ukudla esikudlayo.
"Lokhu esikugulisa la mabhaktheriya ngokuhamba kwesikhathi kuthonya okwenzeka emzimbeni wethu," kusho uStanley Hazen, MD, Ph.D. , Isihloko se-Cardiology eVimbelayo eCleveland Clinic, oholele ucwaningo lwesikhungo kule ndawo.
I-laboratory uDkt. Hazen yenza izifundo eziyinhloko ukuthola ukuxhumana okuhambisana phakathi kwamagciwane nezifo zenhliziyo ngezinto ezibizwa ngokuthi i-trimethylamine- N- oxide (TMAO).
I-TMAO yakhiwa kusuka ezakhiweni ezivame ukutholakala emikhiqizweni yesilwane.
Lezi zifundo, kanye nokuthola okusemqoka okulandelayo, kubonise ukuthi amabhaktheriya athile emathunjini ashintsha kanjani i-choline-eyakhiwe i-lecithin etholakala enyameni, emaqanda amaqanda kanye nemikhiqizo yobisi ephakeme kakhulu-ku-trimethylamine (TMA), engena emzimbeni wegazi kanye ne-metabolized ngesibindi. Lapho, i-TMA iguqulwa ibe yi-TMAO, ebonakala iyisidlali esikhiqiza eziningana zezinqubo zezifo ezixhunywe enhliziyweni nasezindongeni zamathambo egazi.
Ngaphezu kwalokho, lezi zifundo zembula ukuxhumana okucacile phakathi kwamazinga aphezulu e-TMAO namazinga aphezulu okuhlaselwa kwenhliziyo, isifo sohlangothi , nokufa phakathi neminyaka emithathu kubantu, kanye nesifo senhliziyo esisheshayo ezinhlobonhlobo zezilwane.
Isitifiketi sikaDkt. Hazen futhi sibonise ukuthi inqubo efanayo ye-gut microbe-based inendima ekufakeni isifo senhliziyo esheshayo ngemva kokungenwa kwe-L-carnitine, isakhi esitholakala ngokwemvelo ezinhlotsheni eziningi ezibomvu kodwa futhi sinezengezo ezivame ukuphuza iziphuzo zamandla. Ucwaningo lubuthole ukuthi umhubhe uphinde uphenduke i-L-carnitine ibe yi-TMA (bese i-TMAO) nokuthi i-TMAO inengxenye yezifo zenhliziyo ngokuyingxenye ngokushintsha indlela umzimba osebenzisa ngayo i-cholesterol. I-TMAO nayo yaboniswa ukuthi ibangele ukuvuvukala emithanjeni yegazi futhi idale amapulanka engazinzile emadwaleni omshini, ngaleyo ndlela ikhulise ingozi yokuhlasela kwenhliziyo.
Ukungaphumeleli Inhliziyo
Ucwaningo olwengeziwe yiqembu likaDkt. Hazen libonise ukuxhumana phakathi kweTMAO endleleni nokuhluleka kwenhliziyo. Lapho behlola indima ye-TMAO ezigulini ezinesimo esiqinile sezinhliziyo, bathola ukuthi izinga eliphezulu le-TMAO, ingozi enkulu yokufa kwenhliziyo.
"Le ngozi yayiyiqiniso ngaphandle kwanoma yiziphi ezinye izingozi zendabuko futhi kungakhathaliseki ukuthi zisebenza kanjani izinso noma izimpawu zegazi ezibonisa ukucindezeleka kwenhliziyo," kusho uDkt. Hazen. Kulesi sifundo, amazinga aphezulu e-TMAO angaphezu kokuphindwe kathathu ingozi yokufa.
Izifo Zezinso
Izimo zengozi zendabuko aziboni ukuthi izingozi zezinhliziyo ziyanda kulabo abanezifo ezinenkinga yokukhubazeka (izimo ezibizwa ngokuthi isifo esingenasifo sezinso nesifo sokuphela kwezinso).
Ithimba likaDkt. Hazen lithola ukuxhumana phakathi kwendlela ye-TMAO, isifo sezinso, nezinkinga eziphakeme zezinhliziyo ezibhekene nabantu abanomsebenzi wezinso owehla. Ngaphezu kokubonisa isixhumanisi phakathi kwe-TMAO kanye nenkinga ephakeme yengqondo emithonjeni enezinso ezinzima, bathola (ezinhlobonhlobo zezilwane) ukuthi badle amazinga amaningi okwenyuka ngokudla kanye nokuvezwa kwamazinga aphezulu we-TMAO ngokuhamba kwesikhathi okubangela ukutholakala kwezicubu ezincane (fibrosis) ezinso. Lokhu kungabangela umsebenzi wezinso ukuba wehle.
Esinye isifundo, uDkt. Hazen wabona abantu abanezinkinga zezinso ezingenayo izinso iminyaka emihlanu. Uthole ukuthi labo abanamazinga aphezulu e-TMAO lapho ukuqala kokucwaninga kwakungenzeka ukuthi banciphise ngokushesha emsebenzini wezinso, ukuhlaselwa yinhliziyo, ukushaya isifo noma ukufa-kuqhathaniswa nalabo abanezinga eliphansi le-TMAO.
Ngaphezu kwalokho, njengoba umsebenzi wezinso wehla, amazinga e-TMAO akhuphuka ngoba i-TMAO idonswa izinso. UDkt. Hazen uyabika: "Amazinga aphezulu e-TMAO agcinwe angachaza ukuthi kungani abantu abanesifo esibi kakhulu sezinso bevame ukungena engozini yokufa ngesifo senhliziyo."
Ucwaningo Olwengeziwe nokuthola
Leli dolobha likaDkt Hazen liyaqhubeka nokuphenya indima ye-TMAO kwezinye izinqubo zezifo. Izifundo kuze kube yimanje ziqinisekisa ukuthi izidakamizwa zokugulisa, ngokusebenzisa isizukulwane se-TMAO, ziyisidlali esikhulu empilweni yempilo. Iningi lwakamuva, izifundo ezivela endaweni ye-lab ye-Hazen kuya ekwenzeni i-TMAO ekuhloleni kwesifo somzimba-isifo sezintambo zomlenze-nasekubunjweni kwezindwangu zegazi ezingaholela ekuhlaselweni kwenhliziyo nokushaywa yisifo.
Ukutholakala kwamagciwane amakhulu kanye ne-TMAO endleleni kuxhumene nempilo ye-cardiovascular kuvula umnyango wezinyathelo eziningi ezingase zibe khona. Ukuthuthukiswa kwezincomo zokudla kanye nokudla kuyisenzo esisodwa esicacile. Enye ukuthi ukuqashelwa kwalendlela kuholele ekuhloleni okusha kokuhlola kanye nokwelashwa okungenzeka okubhekiswe ezinkambisweni ezincane ezinomthelela ezifweni zenhliziyo.
Ucwaningo olwenziwa yiqembu likaDkt. Hazen lubonise ukuthi ukubhekisa isinyathelo sokuqala ekudalweni kwe-TMAO-ukukhiqizwa kwe-TMA, okuguqulwa ibe yi-TMAO ngamagciwane-kungasiza ekuvimbeleni i-atherosclerosis (ukuqina kobuchopho) ezinhlobonhlobo zezilwane. Le ndlela entsha ithatha isithembiso sokusetshenziswa kwayo ekugcineni njengokwelashwa kokuvimbela ukuhlasela kwenhliziyo, ukushaya isifo, nokunye ukubonakaliswa kokuqina kwesifo somzimba.
Isibonelo, lapho amagundane edliwe ukudla okucebile ku-choline noma i-carnitine (efana nokudla kweWestern), babhekana ne-atherosclerosis esheshayo. Ngesikhathi isigamu samagundane ekudleni okwenziwe nge-high-choline zanikezwa izinto eziyimvelo ezivimbela umgwaqo we-microbial oholela ekubunjweni kwe-TMAO, kwenzeke ukuthi i-atherosclerosis engaphansi. Imvelo yemvelo esetshenziselwa amagundane, etholakalayo emafutheni abanda amakhaza, amafutha omnqumo angasetshenzisiwe kanye namafutha omvini, nawo waboniswa ukuthi uphephile kakhulu, ngisho nasezingeni eliphezulu.
Lokhu kusho ukuthini lokhu
Ubufakazi obusha buxhumanisa nezinambuzane zokugaya umzimba kanye nempilo yenhliziyo. Futhi ukudla yiyona nto ebaluleke kunazo zonke ezithinta ukwakhiwa kwe-microbe nokusebenza. "Izifundo, kuze kube yimanje, zisho ukuthi ukudla ukudla lapho umuntu edla inyama encane nemikhiqizo yezilwane, njengokudla kwemifino noma ye-vegan kanye nokudla kwaseMedithera, kungase kuzuze ngokukhethekile, ikakhulukazi uma unengozi ephezulu yengqondo, ukwehluleka kwenhliziyo, noma isifo esingenasifo sezinso, "kusho uDkt. Hazen.
Ngokuqondene nathi sonke, uyanezela ukuthi kunzima ukusho ukuthi noma ukusika noma ukusika inyama ebomvu, ubisi, namaqanda kungasisiza ukuba siphile isikhathi eside, nokuphila okunempilo. Kodwa-ke, ukuhlolwa kwegazi kwe-TMAO manje kuyatholakala kanti uDkt. Hazen uyaphawula ukuthi ingasiza iziguli ngabanye ukuba zithole ukuthi izinga lakhe le-TMAO liphakeme kangakanani. Ukwazi izinga lakho le-TMAO linganikeza isithombe esicacile senengozi yakho yengqondo, "usho kanje.