Indlela isisu esenza ngayo isiteji se-Ulcer-kubangela amabhaktheriya
Abahluphekayo bachaza isilonda njengesifo esivuthayo, esiqhaqhaqhaqhazelayo, sogwaja, noma esilimaza esiswini esifike emagagasi, izinsuku ezintathu kuya kwezine ngesikhathi, kodwa singase siphumelele ngokuphelele amasonto noma izinyanga. Ubuhlungu bubi kakhulu ngaphambi kokudla nangesikhathi sokulala lapho isisu singenalutho. Isilonda ngokwawo siyisifo esivulekile emgodini wesisu (isisu esiswini) noma engxenyeni engenhla yamathumbu amancane, noma i-duodenum (i-duodenal ulcer).
Zombili izinhlobo zibizwa nangokuthi izilonda ze-peptic .
Isisu se-Acidic: Ukubeka Isiteleka se-Ulcers
Isisu yingxenye eyinhle kakhulu yomzimba, ibeka isiteji kokubili ukuthuthukiswa kwesilonda nokutheleleka. Izinhlobo ezintathu zamangqamuzana zixosha izithako zejusi esiswini: ama-cell-secreting cells, amangqamuzana asemqoka akhipha ama-enzymes okugaya, nama-parietal cells aveza i- hydrochloric acid . Amangqamuzana e-mucus-secreting nawo akhiqiza i-histamine, evuselela amangqamuzana e-parietal ukukhulula i-asidi. Isisu sidinga imvelo ye-asidi ye-enzyme yokugaya inyama ye-pepsin ukuphula amaprotheni ekudleni.
I-Acidity ilinganiswa ngokusebenzisa isikali se-pH. I-pH engathathi hlangothi ayiyona i-asidi noma isisekelo - inenani le-7; ama-acids angaphansi kuka-7, futhi izisekelo (ezibizwa nangokuthi izinto ezinama-alkaline) zinkulu kunezingu-7. Amanzi amaningi omzimba, kuhlanganise negazi, izinyembezi, ijusi le-pancreatic, ne-bile, asezingeni le-7 kuya ku-8 le-pH. I-gastric juice, ngokuphambene, ine-pH ka-1.6 kuya ku-1.8.
Lokho kuyasebenza kakhulu kunejusi lemon, iziphuzo ze-cola, nekhofi. Imvelo emathunjini amancane ayicacile kakhulu kunesisu, kodwa ngoba ithola ingxube ye-acidic yokudla okwesibindi esisuka esiswini, iyakwazi ukuguliswa isilonda.
I-innermost lining line, i-mucosa, iyalondoloza ekuzigayeni ngokwayo.
I-mucosa iqukethe amangqamuzana amancane, izicubu ezixhunyiwe, kanye nemisipha. Isilonda sibuhlungu uma singena ngaphakathi kwe-mucosa singena ngaphansi kwe-submucosa, enesisindo nemithambo yegazi.
Ulcer-Kubangela amabhaktheriya
I-hoop ye-goop esebenzayo ingabonakali indawo yokungenisa izihambi ze-microbe, kodwa uhlobo oludala izilonda ( H. pylori ) lukhula emvelweni we-pH ophansi. "Kunemiphakathi ebizwa ngokuthi i-flagella evumela ukuba bangene emgqeni wesisu, lapho i-pH ikwazi ukubekezeleleka khona. Ukuqeda lezi zinhlamvu akulula," kusho uDkt. Gallo-Torres. Isidakamizwa se-antibiotic kufanele sikwazi ukubulala amabhaktheriya, kodwa futhi nciphise ukuphazamiseka endaweni eziyinkimbinkimbi.
Abacwaningi abaqiniseki ukuthi abantu bathola kanjani amagciwane. Noma kunjalo, ukuhanjiswa komuntu ngamunye kuyalelwa ukuthi kuyindlela engenzeka kakhulu emazweni athuthukile. Emazweni asathuthuka, ukudluliselwa komlomo ngokweqile kungadlala indima ebaluleke kakhulu, efana nendlela umuntu asebenzisana ngayo nekhamera nesifo sofuba
Ukwelapha Ulcers, Khona-ke Namuhla
Ekuqaleni kwekhulu lama-20, imithi yesilonda yayikuphumula nokulala, esibhedlela uma isiguli singakwazi ukuyikhokhela. I-Antacids yanezelwa ekwenzeni ukwelashwa lapho abacwaningi bezwa ukuthi iziguli zesilonda zikhiqiza isidumbu esiningi ngokweqile.
Ngo-1971, indawo yokulawulwa kwe-asidi yokufihla yabonakala - i-histamine (H2) receptors kuma-parietal cells.
Lapho i-histamine ibopha imitholampilo enjalo, umkhiqizo we-asidi ukwanda. Izidakamizwa ezine ezinezilonda ezivunyelwe - i- Zantac (ranitidine), i- Tagamet (cimetidine), i- Pepcid (i-famotidine) ne-Axid (i-nitrodine) - ivimbela i-H2 receptors, isusa isignali ku-secrete acid. Uhlobo lwesibili lwesilonda sesilonda, okuthiwa i-acid- noma i-proton-pump inhibitor, lisebenza endaweni ehlukile ekugayeni, kuvimbela amangqamuzana e-parietal ekukhipheni i-asidi. I-Prilosec (i-omeprazole) yiyona kuphela i-acid-pump inhibitor evunyelwe e-United States ngalesi sikhathi yokwelashwa kwezilonda.
Inkinga ngezidakamizwa ezikhona ukuthi zithuthukisa okwesikhashana izimpawu; i-ulcer kungenzeka ibuyele. Yingakho ama-antibiotic yindlela yokuqala yokuvikela izilonda. Uma amabhaktheriya enza ezinye izilonda ziqedwa, noma kunjalo, amathuba okuphindaphindiwe kwesilonda aphansi ngoba inkinga ihlaselwa emthonjeni wayo.
Umthombo:
> I-National Digestive Information Clearinghouse (NDDIC) Yini Engidinga Ukuyazi Ngezilonda ZasePeptic? Ukushicilelwa kwe-NIH No. 11-5042 - Kubuyekezwe ngo-Okthoba 2012.