Ngasekuqaleni kwawo-1940, ososayensi bebeqaphele ukuthi abantu abavelele ukushisa kwelanga babe namanani aphezulu emdlavuza wesikhumba, kodwa izinga eliphansi lamanye amagciwane. Kule minyaka, izifundo zathola ukuhlukahluka kwezwe ezindaweni zama-khansa ahlukene angu-24, ezinamazinga angaphansi a kansela ezindaweni ezinokukhanya okukhulu kwelanga.
Namuhla, kucacile ukuthi i- vitamin D ngokuyinhloko ibangela ukuhlukahluka kwalokhu, futhi sinesibindi esinamandla sokulondoloza amazinga anesisindo e-vitamin D anele ukusiza ukuvimbela umdlavuza webele wezinhlobo eziningi ezibandakanya, kanye nesifo senhliziyo, izimo ezizimele, kanye ne-osteoporosis.
I-Link Between Vitamin D ne-Cancer Breast
Phakathi kwabesifazane abanomdlavuza webele , cishe amaphesenti angama-75 anesithambile se-vitamin D. Abesifazane abanamazinga awanele egazini e-vitamin D abatholakali ukuthi banesifo somdlavuza webele, nalabo abanesifo somdlavuza wesifuba abasencane amathuba okuthola ukuphindaphinda kwesifo uma amazinga abo e-vitamin D anele. Ngonyaka we-2014, ukuhlaziywa kwe-meta-tests ezinama-56 kwaqedela ukuthi u-vitamin D3 ukwengezwa kwahlanganiswa nokunciphisa amaphesenti angu-12 engozini yokufa kunoma yimuphi umdlavuza.
I-Vitamin D ingaba nethonya elikhethekile lokuvikela umdlavuza webele. Lokhu kwenzeka ngesikhathi kuhlolwa abesifazane abangaphezu kuka-57 000 be-postmenopausal ukuthi abesifazane abathatha isisindo sevithamini D banesilinganiso sokunciphisa amaphesenti angu-26 engozini yomdlavuza webele. Yini eyenza lokhu kutholakala ngokuphawulekayo ukuthi kwenzeka ikakhulukazi kwabesifazane abaye basebenzisa i- hormone therapy esikhundleni .
Ukusetshenziswa kwe-hormonal substitution therapy kwabesifazane be-postmenopausal behla ngokuqinile ngemva kuka-2002, lapho isifundo esikhulu, esibizwa ngokuthi i-Women's Health Initiative, simiswa ngokushesha ngenxa yokwanda kwengozi yesifo senhliziyo, isifo sohlangothi, nesifo somdlavuza weqembu ekwamukelweni ukwelashwa kwe-hormone.
I-Estrogen iyaziwa ukugqugquzela ukukhula nokwanda kwamaseli omdlavuza webele.
Ukutholakala okuphezulu kokutholakala kwe-estrogen, ngenxa yezici ezinjengokuqala kokuya esikhathini nokweqile kwamafutha omzimba , kuhlobene nengozi enkulu yomdlavuza webele. Izithako ze-Vitamin D kungenzeka ukuthi ziphikisana nemiphumela yokukhuthaza umdlavuza we-hormone.
Ezinye izici zokudla eziphikisa izenzo noma ukukhiqizwa kwama-estrogen zihlobene nengozi enciphise yomdlavuza webele. Izibonelo ezimbalwa: amakhowe aqukethe i-aromatase inhibitors (i-aromatase i-enzyme eyenza i-estrogen); ama-soybean kanye ne-flax kanye nezinhlamvu ze-chia ziqukethe ama-phytoestrogens anomphumela we-anti-estrogenic; ukudla okuphezulu-fiber kusiza ukuphuma kwe-estrogen. I-Vitamin D ibonakala inemiphumela efanayo.
Ngokwezifundo ze-vitro on amangqamuzana omdlavuza wesifuba, uhlobo olusebenzayo lwevithamini D lokuphefumula i-aromatase expression, okuholela ekukhiqizeni okuncane kwe-estrogen. I-Vitamin D nayo iye yaboniswa ukunciphisa inani lama-receptors e-estrogen kumaseli omdlavuza webele wekhanda, okwenza amangqamuzana angaphenduli ama-hormonal-promotional signals.
Ingabe Ukushisa Kwanele Kwanele?
Ukwenziwa kwe-Vitamin D esikhumbeni kuyahlukahluka phakathi kwabantu. Ayikho isikhathi esithile sokuchayeka kwelanga nsuku zonke okuzosebenza kuwo wonke umuntu, futhi abaningi bethu, ukukhanya kwelanga okulinganayo ngeke kube ngokwanele.
Ekucwaningweni kwabakhileyo baseHawaii abanokukhanya kwelanga-isilinganiso samahora angu-29 ngesonto-cishe amaphesenti angu-50 babesenamazinga e-vitamin D angaphansi kuka-30 ng / ml. Ngaphezu kwalokho, abanye bethu baphila ezindaweni eziphakeme ezenza u-Vitamin D ngokwanele kube nzima.
Indlela engcono kakhulu yokwazi ngokuqinisekile ukuthi uhlolwa 25 (OH) D wegazi. Sincoma ukusebenzisa ama-supplements ukuze sifinyelele endaweni enhle ka-30-45 ng / ml. Kubantu abaningi, umthamo wansuku zonke olinganiselayo wevithamini D3 eyengeziwe (cishe 1000-2000 IU / usuku) kufanelekile ukuba ufinyelele lelo fenisha elingama-30-45 ng / ml.
> Imithombo:
> Grant WB. Ucwaningo lwezinto eziphilayo ze-UVB-vitamin D-cancer hypothesis. Anticancer Res 2012, 32: 223-236.
> Krishnan AV, Swami S, Feldman D. Izinzuzo zokwelapha ezikhona zika vithamini D ekwelapheni umdlavuza webele we-estrogen receptor. I-Steroids 2012, 77: 1107-1112.
> Isipho C, Fournier A, Mesrine S, et al. Ukusebenzisana phakathi kwe-vitamin D ekwengeziwe kanye nokwelashwa kwe-hormone yama-menopausal kusetshenziswa engozini yomdlavuza webele: ubufakazi obuvela eqenjini le-E3N. Am J Clin Nutr 2015, 102: 966-973.
> Binkley N, Novotny R, Krueger D, et al. I-vitamin D isimo esiphansi naphezu kokushisa kwelanga eliningi. J Clin Endocrinol Metab 2007, 92: 2130-2135.
> Bischoff-Ferrari HA. I-serum ephelele yama-25-hydroxyvitamin D emiphumela eminingi yezempilo. Adv Exp Med Biol 2008, 624: 55-71.