Nakuba kungekho ukwelashwa kwesifo sikaParkinson , kunemithi eminingi etholakalayo ukusiza ukulawula izimpawu zalesi sifo esiqhubekayo.
Isetshenzisiwe yedwa noma (ngaphezulu) inhlanganisela, lezi zidakamizwa zivumela umzimba wakho ukuba usebenze kangcono, okukusiza ukuthi wenze izinto ozifunayo noma okudingeka uzenze.
Abantu abane-Parkinson bangasiza ngokwazi ukuthi lezi mithi zisebenza kanjani, yiziphi izinzuzo ezingase zinikeze, nokuthi yimiphi imiphumela emibi engabangela. Khona-ke, lapho udokotela wakho ebonisa ushintsho noma ukungezelela izidakamizwa ozithathayo, ungenza isinqumo esinolwazi ukwelashwa kwakho.
I-Dopamine Replacement Therapy
I-Levodopa , noma i-L-dopa njengoba kuvame ukuyaziwa, kubhekwa ukwelashwa okujwayelekile kwegolide kwesifo sikaParkinson futhi kuyisisetshenziswa esivame ukusetshenziswa kakhulu ngesimo.
Lesi sidakamizwa siguqulwa sibe yi-neurotransmitter dopamine ebuchosheni, ephindiselela ukuhlinzekwa kwe-dopamine elahlekile njengoba lesi sifo siqhubeka. Ngokwenza njalo, uL-dopa ithuthukisa izimpawu zesifo se-Parkinson.
I-Dopa iphumelela kakhulu kodwa ingabangela ezinye imiphumela emibi kakhulu, kuhlanganise nokunyakaza okungazibandakanyi (okubizwa ngokuthi ama-dyskinesias). Ngokuvamile kubhalwe ngokuhlanganiswa nomunye umuthi okuthiwa i-carbidopa okunciphisa leyo mibi.
I-Dopamine Agonists
Imithi yesibili esetshenziselwa kakhulu isifo sikaParkinson yizidakamizwa ezibizwa ngokuthi i-dopamine agonists. Esikhundleni sokushintsha i-dopamine ebuchosheni bakho, lezi zidakamizwa zikhohlisa ubuchopho bakho ekucabangeni ukuthi kune-dopamine eyanele. Izidakamizwa zenza lokhu ngokubopha ezithombeni ezihloselwe i-dopamine ebuchosheni.
I-dopamine agonists iyasiza ekunciphiseni izimpawu zesifo se-Parkinson. Zingasetshenziswa zodwa noma zihlangene no-L-dopa.
Imiphumela emibi evamile ye-dopamine agonists ihlanganisa ukunxanxathela, ukuhlanza nokudonsa kwegazi. Abanye abantu bangase bathuthukise ukuziphatha okuphoqelekile, okuthatha ingozi ngenkathi bethatha lezi zidakamizwa, ezinganciphisa ukusetshenziswa kwazo.
Ama-Inhibitors we-MAO-B
I-Monoamine oxidase inhibitors - eyaziwa njenge-MAO-B inhibitors - okokuqala isetshenziselwa ukwelashwa kokucindezeleka, kodwa futhi iyasiza ekwelapheni isifo sika-Parkinson. Lezi zidakamizwa zivimbela ukuhlukana komzimba wakho we-neurotransmitter dopamine ebuchosheni bakho, okusiza ukugcina i-dopamine inikeze kakhulu futhi ukunciphisa izimpawu zakho ze-Parkinson.
Ama-inhibitors ama-MAO-B asetshenziswa kakhulu ku-Parkinson afaka i-Eldepryl ne-Zelapar (selegiline) ne-Azilect (rasagiline). Zingahle zenziwe zodwa noma ezinye izidakamizwa zikaParkinson, nemiphumela emibi ingabandakanya ukucabangela, ikhanda, umlomo owomile, isizungu, ukuleleka nokulahlekelwa ukudla.
Abacwaningi baye babheka ukuthi ngabe ama-inhibitors ama-MAO-B empeleni anganciphisa ukuqhubeka kwesifo sika-Parkinson (kunokuba nje nje kuthuthukise izimpawu), kodwa sekuphelile akukho bufakazi balokho. Noma kunjalo, izidakamizwa zisiza ukuphatha izimpawu zikaParkinson.
Okuningi
Eminye Imithi
Kuneminye imithi eminingi esetshenziselwa ukuzama ukuthola ukuthi ukulingana okuphelele kweminye imithi nemiphumela emibi kakhulu.
Iqembu lemithi ebizwa ngokuthi i-COMT inhibitors, isibonelo, lingasiza uL-dopa okungaphezulu ukuba afinyelele ebuchosheni ngokuvimbela umzimba ukuba ungawunqamuli. I-Comtan (i-entacapone) no-Tasmar (i-teconone) yizibonelo ezimbili ze-COMT inhibitors.
I-Symmetrel (i-amantadine) isebenza ngokwandisa inani le-dopamine eyenziwa ngumzimba wakho futhi ivimbela umzimba wakho ukuba ungaqedi i-dopamine ekhona. Isetshenziswe ekuqaleni kukaParkinson ukuphatha izimpawu, futhi kungasiza ngokunyakaza okungahambi kahle okuvela ku-L-dopa.
Ama-anticholinergics afana noCogentin (benztropine) awavame ukusetshenziswa kodwa angasiza iziguli ezincane zikaPasinson zilawula ukuthuthumela. Bhekisela kwenye i-neurotransmitter ebuchosheni - acetylcholine.
Ekugcineni, u-Exelon (rivastigmine), umuthi we-classic cholinesterase inhibitors, uvunyelwe ukwelashwa kwengqondo ku-Parkinson. Kungasiza ukuthuthukisa imemori yakho nokusebenza kwansuku zonke.