I-Metformin yisidakamizwa esivame ukushiwo, ngaphandle kwelebuli, yokwelashwa kwe-PCOS nokulawula ukuvuthwa. Kungenxa yeklasi yezidakamizwa ezithuthukisa impendulo yamaseli ku-insulin futhi ilawula ushukela wegazi . Umshini wokukhishwa kwelebuli ongekho obala ukuthi i-FDA ayizange ivumele ukusetshenziswa kwesidakamizwa ngokuqondene naleso simo. Kulesi simo, i-metformin ivunyiwe ukwelashwa kwesifo sikashukela kodwa hhayi i-PCOS ngokuqondile.
Indlela iMetformin Isebenza ngayo
Ngenxa yokuthi abesifazane abaningi abane-PCOS nabo banesifo sikashukela nesifo sikashukela, kukholelwa ukuthi ukuphathwa kwe-insulin ukungasebenzi kungase kube nomthelela kwezinye izimo ezingenayo i-hormonal ezihlobene nesimo. Ngenkathi abacwaningi bengayiqiniseki ngokuqondile, kunobunye ubufakazi bokuthi uphakamisa le mbono: ezinye izifundo zibonise ukuthi abesifazane abathinte inhlanganisela ye-metformin ne-clomid (isidakamizwa esisetshenziselwa ukudala ukuvuthwa kwabesifazane abaphefumulayo) Ukusabela kangcono emkhakheni wezokwelapha kunelabo abathatha i-clomid yedwa. Abanye besifazane abane-PCOS, ikakhulukazi labo abangamelana ne-insulin, bangabona isikhathi esiningi sokuthatha imetformin.
I-Metformin Isilinganiso
Izilinganiso eziphakathi kuka-1,500 mg kuya ku-2,000 mg nsuku zonke zivamile, kuye ngokumelene nokumelana nokushukela kwe-insulin kanye nezingozi zemiphumela emibi. Abesifazane abaningi bathatha i- metformin kubika ukuthi banezifo eziphuthumayo , isicashu kanye nesifo sohudo - ikakhulukazi ngamazinga aphezulu.
Udokotela angase ancoma kancane kancane ukwandisa umthamo wakho kuze kube yilapho ufinyelela umthamo onqunyiwe ukwandisa ukubekezela kwakho kulo muthi. Abanye odokotela bayakuncoma ifomu lokukhululwa elinikeziwe , okusho ukuthi inani elincane lemithi likhishwa usuku lonke, esikhundleni sabo bonke ngesikhathi esisodwa njengethisha lokuphumula elivamile.
Kubalulekile ukuthatha imithi yakho njengoba nje kunqunywe futhi uvumele udokotela wakho wazi uma uhlangabezana nanoma yimiphi imiphumela emibi .
I-Metformin ne-Early pregnancy Loss
Ngaphezu kobunzima bokukhulelwa, abesifazane abane-PCOS bangase babe engozini yokulahlekelwa ukukhulelwa. Lokhu kungenxa yokungalingani kwe-hormone namazinga aphezulu e- insulini. Ucwaningo oluthile luye lwabonisa izinga eliphansi kakhulu lokukhulelwa kokukhulelwa kwabesifazane abane-PCOS ethatha i-metformin uma kuqhathaniswa nabesifazane ababengathathi i-metformin.
I-Metformin ne-Gestational Diabetes
Ngeshwa, abesifazane abano-PCOS basengozini enkulu yokuthuthukisa isifo sikashukela sokukhulelwa (isifo sikashukela ngokukhulelwa). Ucwaningo lusekela ukusetshenziswa kwe-metformin ekunciphiseni ubungozi besifo sikashukela esithathelwanayo kubantu besifazane abane-PCOS.
Ukuphepha kwe-Metformin ekukhulelweni kokuqala
Ukwazi ukuthi lesi sidakamizwa singakusiza ekuvikela ukukhulelwa, umbuzo olandelayo uvame ukuphepha. Lezi zifundo ziyakhuthaza: kuze kube manje, i-metformin ayixhunyiwe kunoma yikuphi ukukhubazeka okukhulu kokuzalwa noma ukukhubazeka kokubeletha lapho kuthathwa phakathi nonyaka wokuqala. Ngokusho kocwaningo olwanyatheliswa ku- Human Reproduction , izinsana ezazalelwa oomama ezithatha i-metformin azibonisi ukungafani kokukhula kwesilinganiso, ubude, ukukhula noma ukuthuthukiswa kwentuthuko yezenhlalakahle phakathi nezinyanga ezingu-18 zokuqala zokuphila uma kuqhathaniswa nezingane ezivamile zezingane zase-US.
Uma uhlela ukukhulelwa ngenkathi uthatha i-metformin, qiniseka ukuthi ukhulume nodokotela wakho kusengaphambili mayelana nalokho afuna ukuthi ukwenze uma uthola ukuhlolwa kokukhulelwa okuhle. Ngisho noma i-metformin yisisindo sesigaba B, okusho ukuthi kuphephile kakhulu ekukhulelwe, kungcono ukukhuluma nodokotela wakho futhi ulandele imiyalo yakhe. Gcina engqondweni, wonke udokotela uhlukile, futhi unecebo lakhe ngokuqondene nalokho okufanele wena nomntanakho.
Imithombo:
> Begum MR, > Khanam > NN, Quadir E, et al. Ukuvimbela isifo sikashukela sokugulisa sishukela ngokuqhubeka nokwelashwa kwe-metformin phakathi nokukhulelwa kwabesifazane abane-polycystic ovariary syndrome. I-Journal Obstet Gynaecol Res. 2009; 35 (2): 282-286.
> Glueck CJ, Goldenberg N, Pranikoff J, Loftspring M, Sieve L, Wang P. Ukuphakama, isisindo, nokuthuthukiswa komphakathi phakathi nezinyanga zokuqala ezingu-18 zokuphila ezinganeni ezingu-126 ezalwa nabamama-109 abane-polycystic ovary syndrome Kwaqhubeka i-metformin ngokukhulelwa. Abantu > ukuhlambalaza >. 2004; 19 (6): 1323-1330.
> Khattab S, Mohsen IA, Aboul Foutouh I, et al. Ingabe i-metformin inganciphisa ukudla kwe-glycemic ekukhuleni ekuvimbeleni ukuvimbela i-macrosomia (isifundo se-ROLO): > okungahleliwe > ukulawula isilingo. BMJ. 2012; 345: e5605.
> Kinnunen TI, Raitanen J, Aittasalo M, Luoto R. Ukuvimbela isisindo esiningi ngokweqile > ukuthola-a > ukuhlaziywa kwesibili kwesilingo esilawulwa ngokungahleliwe. I-Euro Clinical Nutr. 2012; 66 (12): 1344-1350.
> Kumar P, Khan K. Imiphumela ye-metformin esebenzisa iziguli ezikhulelwe nge-polycystic evariary syndrome. J Sciences Abantu Abangenacala. 2012; 5 (2): 166-169.
Kubuyekezwe ngu-Angela Grassi, MS, i-RDN PCOS Expert.