Hlola Ne-Gastroenterologist Yakho Ngaphambi Kokuthatha I-Painkiller
Bheka cishe noma yikuphi ikhabhinethi yezokwelapha futhi kungenzeka uthole i-NSAID (izidakamizwa ezingezona isifo sokuvuvukala). Ama-NSAID, asetshenziselwa ukuphatha ubuhlungu nokuvuvukala, ajwayelekile kangangokuthi ngokuvamile anezakhiwo zawo ezitolo zezidakamizwa. Empeleni, kunakekelwa ukunakekelwa ukuze kuqinisekiswe ukuthi abantu bangathathi nge-NSAIDS ngokweqile, ikakhulukazi ngoba kungaba lula ukusebenzisa okungaphezu kweyodwa yalezi zidakamizwa ezingaphezu kwamakhomithi ukuphatha ubuhlungu nomkhuhlane kusuka emkhuhlane noma okunye okuvamile ukugula.
Okunye ukusetshenziswa kwama-NSAID kubandakanya ukuphatha izinhlungu, ukuhlukunyezwa kwemisipha, ukunyuka kwezinsuku nokukhulula izinhlungu nezinsuku zonke.
Abantu abanezifo zesifo sofuba (IBD) babhekana nezinhlungu nezinhlungu njenganoma ubani omunye. Abaningi nabo babhekana nosizi nsuku zonke ngenxa yezimo ezingaphezulu kwamathumbu ezinjenge- arthritis noma emiphumeleni yemiphumela yezidakamizwa ezifana nokuphatha ikhanda. Kodwa-ke, ezinye ze- gastroenterologists zincoma ukuthi iziguli zabo ze-IBD zihlale kude nama-NSAID. Isizathu: Ama-NSAID angase abe nomthelela omubi kwisifo sikaCrohn kanye nesifo sofuba esiswini.
Indlela ama-NSAID asebenza ngayo
Ama-NSAID asebenza ngokuvimbela ama-enzyme amabili emzimbeni: i- cyclooxygenase-1 (COX-1) ne-cyclooxygenase-2 (COX-2) . I-COX-1 idlala indima ohlelweni lokugaya futhi i-COX-2 idlala indima enqubweni yokuvuvukala. Umsebenzi we-COX-1 ukulawula izinto ezibizwa ngokuthi i- prostaglandins ezivikela uketshezi kwesisu kusuka kuma-asidi okusiza ukugaya ukudla.
I-prostaglandins eyenziwe yi-COX-2 iqondisa inqubo yokuvuvukala kanye nempendulo yobuhlungu.
Lokhu kusho ukuthi ngenkathi ama-NSAID ehlisa umjikelezo wokuvuvukala nobuhlungu, futhi kubangela ukuthi uhlelo lokugaya lulahlekelwe ezinye izinto ezivame ukuzivikela. Lokhu kungadala izinkinga eziningi kubantu abavele benesifo sokuvuvukala, noma kungenzeka ukuvuvukala, endleleni yabo yokugaya.
Ama-NSAID Nama-Ulcers
Ngisho nabantu abangenawo i-IBD, ama-NSAID angabangela izilonda esiswini nasengxenyeni yokuqala yamathumbu amancane ( duodenum ). Ama-NSAID angabangela ukuvuvukala nokuphuluka kakhudlwana emathunjini amancane. Ezinye izazi zokugaya zikhathazeka ngokuthi ama-NSAID angabangela i-IBD ukuba iphume ekukhululweni .
Ama-NSAID ne-IBD
Ukucwaninga ukuthi ngabe ama-NSAID anikezela emabhalweni e-IBD aphikisanayo, adala ukungqubuzana ekusebenziseni kwabo phakathi kwe-gastroenterologists. Kwisigaba sezidakamizwa okuthiwa i-COX-2 inhibitors, okwamanje akuwona ubufakazi obuningi emiphumeleni yayo kubantu abane-IBD. Olunye ucwaningo lubonisa ukuthi ama-NSAID angathinta kuphela amaphesenti athile abantu abane-IBD, kodwa akunakwenzeka ukwazi ukuthi ubani ozophazamiseka nokuthi ngubani ongekho. Kuye kwacatshangwa ukuthi ukusebenzisa i-COX-2 inhibitor, esikhundleni sokuthi isidakamizwa esiphezulu se-COX-1 kanye ne-COX-2 inhibitor, singasetshenziswa ngokuqapha kulabo abakwa-IBD abakhululwe.
Abantu abane-IBD kufanele baxoxe ne-gastroenterologist yabo ngaphambi kokuba bathathe ama-NSAID, ngisho nalawo atholakalayo phezu kwe-counter. Kubuye kubaluleke kakhulu ukwenza wonke amalungu esigceme sokunakekelwa kwezempilo aqaphele ukuthi ama-NSAID asebenzayo angaba ne-IBD yawo.
Lokho Ababenayo IBD Bangayenza
Abantu abanayo i-IBD abafuna ukuphumula okungaphezulu kwe-counter-the-counter bangase bafise ukucabangela i-acetaminophen.
I-Acetaminophen, edayiswa ngaphansi kwamagama amaningi wegama, kuhlanganise ne-Tylenol, akuyona i-NSAID futhi ingaba yisinqumo esingcono kubantu abane-IBD abadinga ukuhlenga ubuhlungu. Indlela i-acetaminophen esebenza ngayo ukuvimbela ubuhlungu ayiqondakali ngokuphelele, kodwa kucatshangwa ukuthi kuhilela ukuyeka ukudalwa kwe-prostaglandins.
Njalo ubuza ukungezwa kwesidakamizwa esisha semithi, ikakhulukazi lezo ezisetshenziselwa ukuphatha ubuhlungu. Akuwona wonke ochwepheshe wezempilo owazi ukuxhumeka okungenzeka phakathi kweziphazamisi ne-IBD. Lapho abantu abane-IBD bezohlinzwa noma izinqubo, kubalulekile ukukhipha i-gastroenterologist ukuze uthole ingxoxo mayelana nokukhululeka kobuhlungu ukuze uqinisekise ukuthi unolwazi lwamuva mayelana nama-NSAID nokuthi lusebenza kanjani kuwe.
Ngezansi itafula lama-NSAID atholakalayo ngemithi kadokotela noma ngaphezulu kwekhasi. Lokhu akulona uhlu oluphelele, ngakho-ke sicela uthintane nomuthi wemithi noma udokotela ngokukhathazeka ngezidakamizwa ezithile.
Izidakamizwa ezingezona ezama-anti-inflammatory (NSAIDs)
| I gama le-brand | Igama elijwayelekile |
| Advil, Excedrin IB, Genpril, Haltran, Ibuprin, Ibuprohm, Ibu-Tab, Midrin 200, Medipren, Midol IB, i-Motrin, i-Nuprin, i-Pamprin-IB, i-Rufen, i-Trendar | Ibuprofen |
| I-Aleve, i-Anaprox, i-Naprosyn | I-sodium yeNaproxen |
| I-Amigesic, i-Anaflex 750, iMarthritic, i-Mono-Gesic, i-Salflex, i-Salsitab, i-Disalcid | Salsalate |
| Anacin, Bayer, Bufferin, Ecotrin | I-salicylate ye-Choline |
| I-Ansaid, Froben | I-Flurbiprofen yomlomo |
| I-Apo-Keto, i-Orudis, i-Oruvail, i-Rhodis | Ketoprofen |
| I-Apo-Sulin, i-Clinoril, i-Novo-Sundac | Sulindac |
| I-Aspergum, i-Bayer yangempela, i-Bayer Childrens, i-Bufferin, i-Easprin, i-Ecotrin, i-Empirin, i-Genprin, i-Halfprin, i-Magnaprin, i-ZORprin | Aspirin |
| I-Butazolidin | I-Phenylbutazone |
| I-Cataflam, i-Voltaren | Diclofenac Systemic |
| DayPro | Oxaprozin |
| Dolobid | I-Diflunisal |
| UFeldene, uNovo-Pirocam, uNo-Pirox | Piroxicam |
| Indocin SR, Indocid, Novo-Methacin | Indomethacin |
| Lodine | Etodolac |
| Meclomen | I-Sodium yeMeclofenamate |
| I-Mobic | I-Meloxicam |
| Nalfon | I-Fenoprofen Calcium |
| UPonstan, uPonstel | I-Meclofenamic acid |
| Relafen | I-Nabumetone |
| Ukuqoqa | I-Sodium ye-Tolmetin |
Imithombo:
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